Slc7a8 (solute carrier family 7 member 8) - Rat Genome Database

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Gene: Slc7a8 (solute carrier family 7 member 8) Ictidomys tridecemlineatus
Analyze
Symbol: Slc7a8
Name: solute carrier family 7 member 8
RGD ID: 12573583
Description: ENCODES a protein that exhibits amino acid transmembrane transporter activity (inferred); antiporter activity (inferred); glycine transmembrane transporter activity (inferred); INVOLVED IN L-amino acid transport (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); Dwarfism (ortholog); endometriosis (ortholog); FOUND IN apical plasma membrane (inferred); basal plasma membrane (inferred); basolateral plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: large neutral amino acids transporter small subunit 2; solute carrier family 7 member 8, transcript variant X1; solute carrier family 7 member 8, transcript variant X2; solute carrier family 7 member 8, transcript variant X3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,186,625 - 35,245,586 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,143,309 - 1,202,514 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,143,405 - 1,202,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Slc7a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,186,625 - 35,245,586 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,143,309 - 1,202,514 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,143,405 - 1,202,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,125,295 - 23,183,660 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,125,295 - 23,183,674 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,594,504 - 23,652,869 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,664,344 - 22,722,689 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,664,345 - 22,693,450NCBI
Celera143,457,210 - 3,515,570 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,711,422 - 3,770,233 (-)NCBIHuRef
CHM1_11423,593,107 - 23,651,472 (-)NCBICHM1_1
T2T-CHM13v2.01417,325,945 - 17,384,328 (-)NCBIT2T-CHM13v2.0
Slc7a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391454,959,672 - 55,019,343 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,959,666 - 55,019,403 (-)EnsemblGRCm39 Ensembl
GRCm381454,722,215 - 54,781,886 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,722,209 - 54,781,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,341,052 - 55,400,723 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,676,420 - 53,736,091 (-)NCBIMGSCv36mm8
Celera1452,514,886 - 52,574,656 (-)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.91NCBI
Slc7a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,153,016 - 32,212,715 (-)NCBIGRCr8
mRatBN7.21528,183,013 - 28,242,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,183,015 - 28,242,717 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,021,654 - 30,081,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,168,855 - 31,229,070 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,418,621 - 29,478,317 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,369,245 - 33,428,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,369,216 - 33,428,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,253,908 - 37,317,161 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,800,927 - 32,860,797 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,816,626 - 32,876,497 (-)NCBI
Celera1527,761,265 - 27,820,961 (-)NCBICelera
Cytogenetic Map15p13NCBI
Slc7a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540937,119,378 - 37,173,310 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540937,119,189 - 37,171,300 (+)NCBIChiLan1.0ChiLan1.0
SLC7A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,557,789 - 24,616,331 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,774,274 - 23,832,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0143,945,123 - 4,003,574 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,041,386 - 22,100,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,040,787 - 22,100,112 (-)Ensemblpanpan1.1panPan2
SLC7A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,430,208 - 3,479,985 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,430,208 - 3,479,985 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,378,608 - 3,428,266 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,538,051 - 3,587,932 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,538,047 - 3,587,932 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,229,341 - 3,278,991 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,290,333 - 3,340,018 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,552,835 - 3,602,556 (-)NCBIUU_Cfam_GSD_1.0
SLC7A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,854,882 - 75,921,931 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,854,700 - 75,921,931 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,241,975 - 81,259,903 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC7A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,493,987 - 23,556,834 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,493,715 - 23,556,857 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605922,862,343 - 22,923,063 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,365,093 - 9,419,045 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,365,167 - 9,418,346 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000007217   ⟹   ENSSTOP00000006450
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049367221,143,309 - 1,202,514 (+)Ensembl
RefSeq Acc Id: XM_005338766   ⟹   XP_005338823
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864035,188,066 - 35,245,586 (-)NCBI
SpeTri2.0NW_0049367221,143,405 - 1,202,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005338767   ⟹   XP_005338824
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864035,186,625 - 35,200,536 (-)NCBI
SpeTri2.0NW_0049367221,188,456 - 1,202,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013364507   ⟹   XP_013219961
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864035,188,080 - 35,211,678 (-)NCBI
SpeTri2.0NW_0049367221,177,347 - 1,202,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040274474   ⟹   XP_040130408
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864035,186,625 - 35,244,372 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005338823   ⟸   XM_005338766
- Peptide Label: isoform X1
- UniProtKB: I3M9B3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013219961   ⟸   XM_013364507
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005338824   ⟸   XM_005338767
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_040130408   ⟸   XM_040274474
- Peptide Label: isoform X1
- UniProtKB: I3M9B3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000006450   ⟸   ENSSTOT00000007217


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000007210 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000007217.3 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/TrEMBL
  L_AA_transporter UniProtKB/TrEMBL
NCBI Gene Slc7a8 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 2 UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
PIRSF AA_transporter UniProtKB/TrEMBL
UniProt I3M9B3 ENTREZGENE, UniProtKB/TrEMBL