Aass (aminoadipate-semialdehyde synthase) - Rat Genome Database

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Gene: Aass (aminoadipate-semialdehyde synthase) Ictidomys tridecemlineatus
Analyze
Symbol: Aass
Name: aminoadipate-semialdehyde synthase
RGD ID: 12573527
Description: ENCODES a protein that exhibits catalytic activity (inferred); oxidoreductase activity (inferred); saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity (inferred); INVOLVED IN L-lysine catabolic process (ortholog); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; glutaric aciduria type I pathway; hyperlysinemia pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); genetic disease (ortholog); hyperlysinemia (ortholog); FOUND IN intracellular membrane-bounded organelle (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-aminoadipic semialdehyde synthase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511849,012,960 - 49,067,984 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366053,136,018 - 3,190,948 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366053,135,977 - 3,190,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Aass
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511849,012,960 - 49,067,984 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366053,136,018 - 3,190,948 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366053,135,977 - 3,190,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AASS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387122,073,549 - 122,144,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7122,064,583 - 122,144,308 (-)EnsemblGRCh38hg38GRCh38
GRCh377121,713,603 - 121,784,303 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367121,503,423 - 121,561,112 (-)NCBINCBI36Build 36hg18NCBI36
Build 347121,310,137 - 121,367,827NCBI
Celera7116,522,826 - 116,593,571 (-)NCBICelera
Cytogenetic Map7q31.32NCBI
HuRef7116,077,048 - 116,147,810 (-)NCBIHuRef
CHM1_17121,646,898 - 121,717,645 (-)NCBICHM1_1
T2T-CHM13v2.07123,389,454 - 123,460,169 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27121,108,272 - 121,179,018 (-)NCBI
Aass
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39623,072,172 - 23,132,985 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl623,072,172 - 23,132,985 (-)EnsemblGRCm39 Ensembl
GRCm38623,072,173 - 23,132,986 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl623,072,173 - 23,132,986 (-)EnsemblGRCm38mm10GRCm38
MGSCv37623,022,173 - 23,082,986 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36623,022,171 - 23,082,975 (-)NCBIMGSCv36mm8
Celera623,117,896 - 23,183,403 (-)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map610.27NCBI
Aass
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2451,606,461 - 51,663,136 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl451,606,462 - 51,663,136 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx456,573,037 - 56,636,497 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0452,494,066 - 52,557,519 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0450,935,584 - 50,999,363 (-)NCBIRnor_WKY
Rnor_6.0450,152,005 - 50,208,935 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl450,152,452 - 50,200,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0449,938,569 - 49,993,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4449,479,938 - 49,539,782 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1449,710,958 - 49,806,368 (-)NCBI
Celera446,798,734 - 46,861,408 (-)NCBICelera
Cytogenetic Map4q22NCBI
Aass
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554793,742,757 - 3,814,338 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554793,746,003 - 3,805,835 (-)NCBIChiLan1.0ChiLan1.0
AASS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1710,955,958 - 11,026,799 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07114,084,792 - 114,155,558 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17126,769,655 - 126,840,346 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7126,769,655 - 126,840,346 (-)Ensemblpanpan1.1panPan2
AASS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11459,950,123 - 59,993,457 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1459,951,216 - 60,000,212 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1459,366,730 - 59,419,159 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01459,984,503 - 60,037,014 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1459,986,237 - 60,035,749 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11460,076,161 - 60,128,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01459,703,783 - 59,756,172 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01460,081,118 - 60,133,517 (-)NCBIUU_Cfam_GSD_1.0
AASS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1824,974,754 - 25,039,195 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11824,938,366 - 25,039,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21826,579,353 - 26,641,402 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AASS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12190,891,781 - 90,959,351 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2190,892,023 - 90,959,343 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604212,584,431 - 12,655,125 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aass
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478313,831,150 - 13,902,082 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478313,831,220 - 13,904,806 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000015495   ⟹   ENSSTOP00000013872
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366053,136,018 - 3,190,948 (+)Ensembl
RefSeq Acc Id: XM_005333945   ⟹   XP_005334002
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511849,012,960 - 49,067,984 (-)NCBI
SpeTri2.0NW_0049366053,135,977 - 3,190,956 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013362248   ⟹   XP_013217702
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511849,014,088 - 49,067,984 (-)NCBI
SpeTri2.0NW_0049366053,135,977 - 3,190,956 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040291605   ⟹   XP_040147539
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511849,012,960 - 49,067,980 (-)NCBI
RefSeq Acc Id: XM_040291607   ⟹   XP_040147541
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511849,012,960 - 49,067,945 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005334002 (Get FASTA)   NCBI Sequence Viewer  
  XP_013217702 (Get FASTA)   NCBI Sequence Viewer  
  XP_040147539 (Get FASTA)   NCBI Sequence Viewer  
  XP_040147541 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005334002   ⟸   XM_005333945
- Peptide Label: isoform X1
- UniProtKB: I3MPT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013217702   ⟸   XM_013362248
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040147539   ⟸   XM_040291605
- Peptide Label: isoform X1
- UniProtKB: I3MPT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040147541   ⟸   XM_040291607
- Peptide Label: isoform X1
- UniProtKB: I3MPT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000013872   ⟸   ENSSTOT00000015495
Protein Domains
Alanine dehydrogenase/pyridine nucleotide


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000015486 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000013872 ENTREZGENE
  ENSSTOP00000013872.3 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000015495.3 UniProtKB/TrEMBL
Gene3D-CATH Domain 3, Saccharopine reductase UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro AlaDH/PNT_N UniProtKB/TrEMBL
  AlaDH/PNT_NAD(H)-bd UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Sacchrp_dh-like_C UniProtKB/TrEMBL
  Sacchrp_dh_NADP UniProtKB/TrEMBL
NCBI Gene Aass ENTREZGENE
PANTHER ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL UniProtKB/TrEMBL
  SACCHAROPINE DEHYDROGENASE UniProtKB/TrEMBL
Pfam AlaDh_PNT_N UniProtKB/TrEMBL
  Sacchrp_dh_C UniProtKB/TrEMBL
  Sacchrp_dh_NADP UniProtKB/TrEMBL
SMART AlaDh_PNT_C UniProtKB/TrEMBL
  AlaDh_PNT_N UniProtKB/TrEMBL
Superfamily-SCOP Formate/glycerate dehydrogenase catalytic domain-like UniProtKB/TrEMBL
  Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt I3MPT9 ENTREZGENE, UniProtKB/TrEMBL