Fn1 (fibronectin 1) - Rat Genome Database

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Gene: Fn1 (fibronectin 1) Ictidomys tridecemlineatus
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Symbol: Fn1
Name: fibronectin 1
RGD ID: 12568365
Description: ENCODES a protein that exhibits chaperone binding (ortholog); disordered domain specific binding (ortholog); enzyme binding (ortholog); INVOLVED IN biological process involved in interaction with symbiont (ortholog); calcium-independent cell-matrix adhesion (ortholog); cell activation (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Otitis Media (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); basement membrane (ortholog); collagen-containing extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: fibronectin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303170,852,488 - 170,917,088 (-)NCBI
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Otitis Media  (ISO)
Animal Mammary Neoplasms  (ISO)
aortic valve insufficiency  (ISO)
brain disease  (ISO)
Breast Neoplasms  (ISO)
calcium oxalate nephrolithiasis  (ISO)
carcinoma  (ISO)
Cardiac Fibrosis  (ISO)
chronic kidney disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
end stage renal disease  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
Glomerulopathy with Giant Fibrillar Deposits  (ISO)
Hirschsprung's disease  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
iron deficiency anemia  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
malignant mesothelioma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
membranoproliferative glomerulonephritis  (ISO)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
Neurodevelopmental Disorders  (ISO)
osteoarthritis  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
renovascular hypertension  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
spondyloepimetaphyseal dysplasia, Strudwick type  (ISO)
spondylometaphyseal dysplasia  (ISO)
spondylometaphyseal dysplasia corner fracture type  (ISO)
Spontaneous Abortions  (ISO)
Staphylococcal Pneumonia  (ISO)
Sturge-Weber syndrome  (ISO)
submandibular gland disease  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
VACTERL association  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biological process involved in interaction with symbiont  (ISO)
calcium-independent cell-matrix adhesion  (ISO)
cell activation  (ISO)
cell adhesion  (ISO)
cell-matrix adhesion  (ISO)
cell-substrate junction assembly  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to angiotensin  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mercury ion  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
endodermal cell differentiation  (ISO)
extracellular matrix organization  (ISO)
glial cell migration  (ISO)
integrin activation  (ISO)
integrin-mediated signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of transforming growth factor beta production  (ISO)
neural crest cell migration involved in autonomic nervous system development  (ISO)
peptide cross-linking  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of substrate-dependent cell migration, cell attachment to substrate  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of gene expression  (ISO)
regulation of protein phosphorylation  (ISO)
response to activity  (ISO)
response to drug  (ISO)
response to glucocorticoid  (ISO)
response to iron ion  (ISO)
response to ischemia  (ISO)
response to ozone  (ISO)
response to wounding  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
wound healing  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Fn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303170,852,488 - 170,917,088 (-)NCBI
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2215,360,440 - 215,436,073 (-)EnsemblGRCh38hg38GRCh38
GRCh382215,360,862 - 215,436,167 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372216,225,588 - 216,300,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,933,422 - 216,009,036 (-)NCBINCBI36hg18NCBI36
Build 342216,050,686 - 216,126,297NCBI
Celera2209,994,808 - 210,070,377 (-)NCBI
Cytogenetic Map2q35NCBI
HuRef2208,082,209 - 208,158,070 (-)NCBIHuRef
CHM1_12216,231,063 - 216,306,652 (-)NCBICHM1_1
Fn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39171,624,632 - 71,692,439 (-)NCBIGRCm39mm39
GRCm39 Ensembl171,624,679 - 71,692,359 (-)Ensembl
GRCm38171,585,473 - 71,653,280 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl171,585,520 - 71,653,200 (-)EnsemblGRCm38mm10GRCm38
MGSCv37171,632,097 - 71,699,745 (-)NCBIGRCm37mm9NCBIm37
MGSCv36171,518,731 - 71,586,379 (-)NCBImm8
Celera172,141,007 - 72,208,976 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.05NCBI
Fn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2973,196,044 - 73,264,695 (-)NCBI
Rnor_6.0 Ensembl978,900,103 - 78,969,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0978,900,111 - 78,969,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0978,674,437 - 78,743,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,702,181 - 70,771,155 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1970,849,162 - 70,918,137 (-)NCBI
Celera970,607,233 - 70,675,716 (-)NCBICelera
RH 3.4 Map9673.9RGD
Cytogenetic Map9q33NCBI
Fn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955457629,518 - 696,975 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955457629,599 - 694,948 (+)NCBIChiLan1.0ChiLan1.0
FN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B221,208,431 - 221,284,003 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B221,208,431 - 221,284,003 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B102,623,568 - 102,698,747 (-)NCBIMhudiblu_PPA_v0panPan3
FN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13722,456,854 - 22,522,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3722,420,428 - 22,523,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3723,283,410 - 23,349,813 (-)NCBI
ROS_Cfam_1.03722,479,930 - 22,546,207 (-)NCBI
UMICH_Zoey_3.13722,368,332 - 22,434,691 (-)NCBI
UNSW_CanFamBas_1.03722,319,732 - 22,386,105 (-)NCBI
UU_Cfam_GSD_1.03722,336,313 - 22,402,763 (-)NCBI
FN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15117,658,099 - 117,731,014 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115117,658,158 - 117,737,145 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215130,357,895 - 130,430,785 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110101,177,867 - 101,254,613 (-)NCBI
ChlSab1.1 Ensembl10101,176,789 - 101,254,633 (-)Ensembl
Fn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624765707,872 - 775,056 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005331841   ⟹   XP_005331898
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303170,852,488 - 170,917,085 (-)NCBI
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005331842   ⟹   XP_005331899
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303170,852,488 - 170,917,084 (-)NCBI
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005331846   ⟹   XP_005331903
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303170,852,488 - 170,917,082 (-)NCBI
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005331847   ⟹   XP_005331904
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303170,852,488 - 170,917,085 (-)NCBI
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005331849   ⟹   XP_005331906
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303170,852,488 - 170,917,083 (-)NCBI
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013361361   ⟹   XP_013216815
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303170,852,488 - 170,917,085 (-)NCBI
SpeTri2.0NW_0049365861,708,809 - 1,773,372 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013361362   ⟹   XP_013216816
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303170,852,488 - 170,917,083 (-)NCBI
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013361363   ⟹   XP_013216817
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303170,852,488 - 170,917,086 (-)NCBI
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013361364   ⟹   XP_013216818
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303170,852,488 - 170,917,084 (-)NCBI
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021730731   ⟹   XP_021586406
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303170,852,488 - 170,917,088 (-)NCBI
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005331898   ⟸   XM_005331841
- Peptide Label: isoform X1
- UniProtKB: I3M114 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013216817   ⟸   XM_013361363
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_013216816   ⟸   XM_013361362
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013216818   ⟸   XM_013361364
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_005331899   ⟸   XM_005331842
- Peptide Label: isoform X4
- UniProtKB: A0A287CYK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005331904   ⟸   XM_005331847
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_005331903   ⟸   XM_005331846
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_005331906   ⟸   XM_005331849
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_013216815   ⟸   XM_013361361
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021586406   ⟸   XM_021730731
- Peptide Label: isoform X7
- Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002709 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000002458 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000026348 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002748 UniProtKB/TrEMBL
  ENSSTOT00000042567 UniProtKB/TrEMBL
Gene3D-CATH 2.10.10.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro Fibronectin_type1 UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  FN_type2_dom UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
NCBI Gene Fn1 ENTREZGENE
Pfam fn1 UniProtKB/TrEMBL
  fn2 UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
PROSITE FN1_1 UniProtKB/TrEMBL
  FN1_2 UniProtKB/TrEMBL
  FN2_1 UniProtKB/TrEMBL
  FN2_2 UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
SMART FN1 UniProtKB/TrEMBL
  FN2 UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
  SSF57440 UniProtKB/TrEMBL
UniProt A0A287CYK1 ENTREZGENE, UniProtKB/TrEMBL
  I3M114 ENTREZGENE, UniProtKB/TrEMBL