Dmd (dystrophin) - Rat Genome Database

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Gene: Dmd (dystrophin) Ictidomys tridecemlineatus
Analyze
Symbol: Dmd
Name: dystrophin
RGD ID: 12566530
Description: ENCODES a protein that exhibits actin binding (ortholog); dystroglycan binding (ortholog); integrin binding (ortholog); INVOLVED IN aging (ortholog); cardiac muscle cell action potential (ortholog); cardiac muscle contraction (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); Ataxia (ortholog); FOUND IN astrocyte projection (ortholog); axon (ortholog); cell junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: dystrophin, transcript variant X1; dystrophin, transcript variant X10; dystrophin, transcript variant X11; dystrophin, transcript variant X2; dystrophin, transcript variant X3; dystrophin, transcript variant X4; dystrophin, transcript variant X5; dystrophin, transcript variant X6; dystrophin, transcript variant X7; dystrophin, transcript variant X8; dystrophin, transcript variant X9; LOC101963807; LOC110598002; uncharacterized LOC110598002
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X19,065,166 - 21,072,605 (-)NCBI
SpeTri2.0NW_0049365537,157,526 - 7,943,703 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Animal Disease Models  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
Ataxia  (ISO)
autistic disorder  (ISO)
Becker muscular dystrophy  (ISO)
brain edema  (ISO)
calcinosis  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cataract  (ISO)
cognitive disorder  (ISO)
colorectal cancer  (ISO)
congestive heart failure  (ISO)
Dehydration  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Duchenne muscular dystrophy  (ISO)
Duchenne Muscular Dystrophy, Mental Retardation, and Absence of ERG B-wave  (ISO)
embryonal rhabdomyosarcoma  (ISO)
Exertional Myalgia, Muscle Stiffness and Myoglobinuria  (ISO)
Experimental Seizures  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
Funnel Chest  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
hypertrophic cardiomyopathy  (ISO)
intellectual disability  (ISO)
isolated elevated serum creatine phosphokinase levels  (ISO)
leiomyosarcoma  (ISO)
long QT syndrome  (ISO)
Malformations of Cortical Development, Group II  (ISO)
Muscle Cramp  (ISO)
Muscle Weakness  (ISO)
muscular atrophy  (ISO)
muscular dystrophy  (ISO)
Muscular Dystrophy, Animal  (ISO)
myocarditis  (ISO)
myopathy  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neurodevelopmental Disorders  (ISO)
ornithine carbamoyltransferase deficiency  (ISO)
polycystic ovary syndrome  (ISO)
restrictive cardiomyopathy  (ISO)
retinal degeneration  (ISO)
schizophrenia  (ISO)
status epilepticus  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
Ventricular Dysfunction  (ISO)
X-linked adrenal hypoplasia congenita  (ISO)
X-linked dilated cardiomyopathy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
cardiac muscle cell action potential  (ISO)
cardiac muscle contraction  (ISO)
cell differentiation  (ISO)
cellular protein localization  (ISO)
cellular protein-containing complex assembly  (ISO)
cerebral cortex development  (ISO)
establishment of blood-nerve barrier  (ISO)
establishment of glial blood-brain barrier  (ISO)
muscle cell cellular homeostasis  (ISO)
muscle cell development  (ISO)
muscle cell differentiation  (ISO)
muscle organ development  (ISO)
myotube cell development  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of peptidyl-cysteine S-nitrosylation  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
neuron differentiation  (ISO)
neuron projection morphogenesis  (ISO)
neurotransmitter receptor metabolic process  (ISO)
nucleus localization  (ISO)
olfactory nerve structural organization  (ISO)
peptide biosynthetic process  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of sodium ion transmembrane transporter activity  (ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (ISO)
regulation of cell cycle  (ISO)
regulation of cellular response to growth factor stimulus  (ISO)
regulation of gene expression  (ISO)
regulation of heart rate  (ISO)
regulation of membrane potential  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of skeletal muscle contraction  (ISO)
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion  (ISO)
regulation of transcription, DNA-templated  (ISO)
regulation of voltage-gated calcium channel activity  (ISO)
response to denervation involved in regulation of muscle adaptation  (ISO)
response to muscle stretch  (ISO)
response to water deprivation  (ISO)
skeletal muscle tissue development  (ISO)
skeletal muscle tissue regeneration  (ISO)

References

Genomics

Comparative Map Data
Dmd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X19,065,166 - 21,072,605 (-)NCBI
SpeTri2.0NW_0049365537,157,526 - 7,943,703 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX31,097,677 - 33,339,609 (-)EnsemblGRCh38hg38GRCh38
GRCh38X31,119,219 - 33,339,460 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X31,137,339 - 33,357,505 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X31,047,266 - 33,267,647 (-)NCBINCBI36hg18NCBI36
Build 34X30,955,968 - 31,044,681NCBI
CeleraX35,264,860 - 37,484,992 (-)NCBI
Cytogenetic MapXp21.2-p21.1NCBI
HuRefX28,877,768 - 31,095,562 (-)NCBIHuRef
CHM1_1X31,168,731 - 33,388,091 (-)NCBICHM1_1
Dmd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X81,858,244 - 84,248,656 (+)NCBIGRCm39mm39
GRCm39 EnsemblX81,992,476 - 84,249,747 (+)Ensembl
GRCm38X82,814,664 - 85,205,050 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX82,948,870 - 85,206,141 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X80,194,209 - 82,450,389 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X79,201,622 - 81,457,760 (+)NCBImm8
CeleraX74,178,103 - 76,399,942 (+)NCBICelera
Cytogenetic MapXC1NCBI
cM MapX38.38NCBI
Dmd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X47,272,324 - 49,504,219 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX47,272,331 - 49,504,207 (+)Ensembl
Rnor_6.0X51,149,358 - 53,519,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX51,286,737 - 53,519,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X51,475,950 - 53,700,033 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X71,501,362 - 71,671,414 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X71,574,653 - 71,744,706 (+)NCBI
CeleraX49,967,398 - 50,127,432 (+)NCBICelera
Cytogenetic MapXq21NCBI
Dmd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555351,283,523 - 3,299,542 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555351,283,084 - 3,297,015 (+)NCBIChiLan1.0ChiLan1.0
DMD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X31,279,878 - 32,974,614 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX31,282,415 - 33,492,733 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X23,728,650 - 26,338,849 (-)NCBIMhudiblu_PPA_v0panPan3
DMD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X26,290,903 - 28,444,635 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX26,290,910 - 28,333,576 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX31,264,482 - 33,330,008 (-)NCBI
ROS_Cfam_1.0X26,319,830 - 28,487,633 (-)NCBI
UMICH_Zoey_3.1X26,365,124 - 28,433,100 (-)NCBI
UNSW_CanFamBas_1.0X26,358,103 - 28,426,635 (-)NCBI
UU_Cfam_GSD_1.0X26,455,978 - 28,540,050 (-)NCBI
DMD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX27,028,223 - 29,181,689 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X27,028,223 - 29,650,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X29,663,010 - 29,797,624 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2X29,402,260 - 29,549,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2X30,958,632 - 31,033,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2X30,368,459 - 30,440,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2X31,219,126 - 31,875,451 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DMD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X29,543,003 - 32,218,011 (-)NCBIChlSab1.1chlSab2
ChlSab1.1X29,543,003 - 32,218,011 (-)NCBIChlSab1.1chlSab2
ChlSab1.1X29,543,003 - 32,218,011 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605631,608,900 - 34,272,207 (-)NCBIVero_WHO_p1.0
Dmd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476222,306,962 - 24,846,427 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005329172   ⟹   XP_005329229
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365537,160,011 - 7,303,513 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005329174   ⟹   XP_005329231
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365537,157,526 - 7,303,513 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021729001   ⟹   XP_021584676
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365537,157,526 - 7,943,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021729002   ⟹   XP_021584677
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365537,157,526 - 7,943,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021729003   ⟹   XP_021584678
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365537,159,907 - 7,943,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021729004   ⟹   XP_021584679
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365537,157,526 - 7,943,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021729005   ⟹   XP_021584680
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365537,157,526 - 7,943,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021729006   ⟹   XP_021584681
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365537,157,526 - 7,943,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021729007   ⟹   XP_021584682
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365537,157,526 - 7,303,513 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021729008   ⟹   XP_021584683
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365537,157,526 - 7,303,513 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021729009   ⟹   XP_021584684
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365537,157,526 - 7,943,703 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040287799   ⟹   XP_040143733
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X19,065,166 - 21,072,605 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005329229   ⟸   XM_005329172
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_005329231   ⟸   XM_005329174
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_021584684   ⟸   XM_021729009
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_021584677   ⟸   XM_021729002
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021584681   ⟸   XM_021729006
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_021584679   ⟸   XM_021729004
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_021584676   ⟸   XM_021729001
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021584680   ⟸   XM_021729005
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_021584682   ⟸   XM_021729007
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_021584683   ⟸   XM_021729008
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_021584678   ⟸   XM_021729003
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040143733   ⟸   XM_040287799


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028562 ENTREZGENE
NCBI Gene Dmd ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-25 Dmd  dystrophin  LOC101963807  dystrophin  Data Merged 737654 PROVISIONAL
2021-03-25 Dmd  dystrophin  LOC110598002  uncharacterized LOC110598002  Data Merged 737654 PROVISIONAL