Sox17 (SRY-box transcription factor 17) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Sox17 (SRY-box transcription factor 17) Ictidomys tridecemlineatus
Analyze
Symbol: Sox17
Name: SRY-box transcription factor 17
RGD ID: 12565217
Description: ENCODES a protein that exhibits beta-catenin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN angiogenesis (ortholog); cardiac cell fate determination (ortholog); cardiogenic plate morphogenesis (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); Colorectal Neoplasms (ortholog); Teratogenesis (ortholog); FOUND IN nucleus (ortholog); transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: SRY-box 17; transcription factor SOX-17
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530373,534,065 - 73,536,600 (-)NCBI
SpeTri2.0NW_0049364961,248,582 - 1,251,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
cardiac cell fate determination  (ISO)
cardiogenic plate morphogenesis  (ISO)
cell migration involved in gastrulation  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
common bile duct development  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic heart tube development  (ISO)
embryonic heart tube morphogenesis  (ISO)
embryonic organ development  (ISO)
endocardial cell differentiation  (ISO)
endocardium formation  (ISO)
endoderm development  (ISO)
endoderm formation  (ISO)
endodermal cell fate determination  (ISO)
endodermal cell fate specification  (ISO)
endodermal digestive tract morphogenesis  (ISO)
gall bladder development  (ISO)
gastrulation  (ISO)
heart looping  (ISO)
inner cell mass cellular morphogenesis  (ISO)
metanephros development  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of Wnt signaling pathway  (ISO)
negative regulation of Wnt signaling pathway involved in heart development  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
protein destabilization  (ISO)
protein stabilization  (ISO)
regulation of cardiac cell fate specification  (ISO)
regulation of cell differentiation  (ISO)
regulation of embryonic development  (ISO)
regulation of stem cell division  (ISO)
regulation of stem cell proliferation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
rostrocaudal neural tube patterning  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
spermatogenesis  (ISO)
stem cell differentiation  (ISO)
stem cell fate specification  (ISO)
ureter development  (ISO)
vasculogenesis  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Sox17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530373,534,065 - 73,536,600 (-)NCBI
SpeTri2.0NW_0049364961,248,582 - 1,251,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOX17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl854,457,935 - 54,460,892 (+)EnsemblGRCh38hg38GRCh38
GRCh38854,457,935 - 54,460,892 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37855,370,495 - 55,373,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36855,533,048 - 55,536,009 (+)NCBINCBI36hg18NCBI36
Build 34855,533,047 - 55,535,484NCBI
Celera851,361,039 - 51,364,000 (+)NCBI
Cytogenetic Map8q11.23NCBI
HuRef850,838,617 - 50,841,578 (+)NCBIHuRef
CHM1_1855,422,260 - 55,425,221 (+)NCBICHM1_1
Sox17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914,561,151 - 4,567,624 (-)NCBIGRCm39mm39
GRCm39 Ensembl14,561,154 - 4,567,577 (-)Ensembl
GRCm3814,490,928 - 4,497,426 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14,490,931 - 4,497,354 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714,481,009 - 4,486,494 (-)NCBIGRCm37mm9NCBIm37
MGSCv3614,481,009 - 4,486,494 (-)NCBImm8
Celera14,507,797 - 4,513,282 (-)NCBICelera
Cytogenetic Map1A1NCBI
cM Map11.65NCBI
Sox17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2515,016,660 - 15,022,228 (+)NCBI
Rnor_6.0 Ensembl514,890,408 - 14,895,907 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0514,890,318 - 14,895,907 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0519,675,563 - 19,681,084 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4515,241,405 - 15,246,904 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1515,244,440 - 15,246,899 (+)NCBI
Celera514,398,084 - 14,403,591 (+)NCBICelera
Cytogenetic Map5q12NCBI
Sox17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545413,689,403 - 13,690,019 (+)NCBIChiLan1.0ChiLan1.0
SOX17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1848,257,287 - 48,259,808 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl848,257,287 - 48,259,808 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0850,883,088 - 50,885,542 (+)NCBIMhudiblu_PPA_v0panPan3
SOX17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1295,979,092 - 5,981,504 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl295,979,261 - 5,981,124 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha296,289,199 - 6,291,617 (+)NCBI
ROS_Cfam_1.0296,057,575 - 6,059,968 (+)NCBI
UMICH_Zoey_3.1295,992,409 - 5,994,803 (+)NCBI
UNSW_CanFamBas_1.0296,198,380 - 6,200,809 (+)NCBI
UU_Cfam_GSD_1.0296,377,256 - 6,379,697 (+)NCBI
SOX17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl476,852,230 - 76,857,139 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1476,854,218 - 76,857,143 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2483,968,236 - 83,971,155 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOX17
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1850,523,816 - 50,527,360 (+)NCBI
ChlSab1.1 Ensembl850,524,893 - 50,527,847 (+)Ensembl
Sox17
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247351,276,382 - 1,278,584 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005322915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005322915   ⟹   XP_005322972
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530373,534,065 - 73,536,600 (-)NCBI
SpeTri2.0NW_0049364961,248,582 - 1,251,406 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005322972 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005322972   ⟸   XM_005322915
- UniProtKB: I3ND44 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
HMG box   Sox C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000022517 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000022291 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000028236 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
InterPro HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  Sox7/17/18_central UniProtKB/TrEMBL
  Sox_C UniProtKB/TrEMBL
NCBI Gene Sox17 ENTREZGENE
Pfam HMG_box UniProtKB/TrEMBL
  Sox17_18_mid UniProtKB/TrEMBL
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
  SOX_C UniProtKB/TrEMBL
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt I3ND44 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-18 Sox17  SRY-box transcription factor 17  Sox17  SRY-box 17  Symbol and/or name change 5135510 APPROVED