Prss23 (serine protease 23) - Rat Genome Database

Name: Prss23
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Prss23 (serine protease 23) Ictidomys tridecemlineatus

Analyze

Symbol:

Prss23

Name:

serine protease 23

RGD ID:

12559537

Description:

ENCODES a protein that exhibits serine-type endopeptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH Coats disease (ortholog); COVID-19 (ortholog); exudative vitreoretinopathy (ortholog); FOUND IN extracellular space (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

protease, serine 23

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRSS23 (serine protease 23)	NCBI	Ortholog
Mus musculus (house mouse):	Prss23 (serine protease 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Prss23 (serine protease 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prss23 (serine protease 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRSS23 (serine protease 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRSS23 (serine protease 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRSS23 (serine protease 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRSS23 (serine protease 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prss23 (serine protease 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	72,961,118 - 72,963,599 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	14,560,765 - 14,561,913 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	14,560,730 - 14,563,195 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Coats disease (ISO)

COVID-19 (ISO)

exudative vitreoretinopathy (ISO)

exudative vitreoretinopathy 1 (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

intellectual disability (ISO)

melanoma (ISO)

Norrie disease (ISO)

retinal telangiectasia (ISO)

retinopathy of prematurity (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA)

Cellular Component

extracellular space (IEA)

nucleus (IEA)

Molecular Function

protein binding (ISO)

serine-type endopeptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Prss23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	72,961,118 - 72,963,599 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	14,560,765 - 14,561,913 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	14,560,730 - 14,563,195 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRSS23
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	86,791,071 - 86,952,910 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	86,791,059 - 86,952,910 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	86,502,113 - 86,663,952 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	86,189,139 - 86,199,923 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	86,189,210 - 86,199,919	NCBI
Celera	11	83,822,885 - 83,833,669 (+)	NCBI		Celera
Cytogenetic Map	11	q14.2	NCBI
HuRef	11	82,800,718 - 82,811,496 (+)	NCBI		HuRef
CHM1_1	11	86,397,209 - 86,407,989 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	86,731,821 - 86,893,752 (+)	NCBI		T2T-CHM13v2.0

Prss23
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	89,156,988 - 89,176,399 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	89,156,991 - 89,176,395 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	89,507,783 - 89,527,187 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	89,507,783 - 89,527,187 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	96,656,295 - 96,666,096 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	89,382,977 - 89,392,744 (-)	NCBI		MGSCv36	mm8
Celera	7	86,863,519 - 86,873,318 (-)	NCBI		Celera
Cytogenetic Map	7	D3	NCBI
cM Map	7	49.9	NCBI

Prss23
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	152,815,301 - 152,835,005 (-)	NCBI		GRCr8
mRatBN7.2	1	143,402,725 - 143,422,182 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	143,401,396 - 143,422,091 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	151,348,875 - 151,357,260 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	158,525,264 - 158,533,649 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	151,399,177 - 151,407,562 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	153,732,528 - 153,742,111 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	153,732,532 - 153,752,541 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	160,037,248 - 160,056,629 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	146,081,552 - 146,089,928 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	146,159,962 - 146,168,334 (-)	NCBI
Celera	1	141,654,333 - 141,662,709 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

Prss23
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	6,202,383 - 6,213,521 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	6,202,383 - 6,213,521 (-)	NCBI	ChiLan1.0	ChiLan1.0

PRSS23
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	87,722,921 - 87,731,607 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	88,646,843 - 88,782,831 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	81,855,594 - 81,866,321 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	85,454,400 - 85,474,188 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

PRSS23
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	12,792,212 - 12,813,067 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	12,793,373 - 12,803,136 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	12,658,486 - 12,678,952 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	12,975,225 - 12,995,800 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	12,975,421 - 12,986,206 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	12,761,501 - 12,771,319 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	12,834,999 - 12,853,659 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	12,889,347 - 12,900,934 (-)	NCBI		UU_Cfam_GSD_1.0

PRSS23
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	20,603,733 - 20,625,139 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	20,603,676 - 20,623,358 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	22,893,335 - 22,913,017 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRSS23
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	78,058,332 - 78,067,030 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	78,065,492 - 78,066,643 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	47,654,998 - 47,665,912 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prss23
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624845	3,167,528 - 3,175,781 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624845	3,164,746 - 3,176,328 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005323296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000007428 ⟹ ENSSTOP00000006636

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936498	14,560,765 - 14,561,913 (+)	Ensembl

RefSeq Acc Id:

XM_005323296 ⟹ XP_005323353

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	72,961,118 - 72,963,599 (+)	NCBI
SpeTri2.0	NW_004936498	14,560,730 - 14,563,195 (+)	NCBI

Sequence:

show sequence

CTTGTCTTCTTCATTTCTACAGAATTGTGCTCAGCATGGCGGAGATTCCAGGGCTTCTCTTCCT
TCTCCTCCTGCTCTGTGTTGTTGGGCAGGTGAGTCCCTATGGTGCCTTCTGGAAACCCACTTGG
CCTGCTTACCGCCTCCCTGTAGTCTTGCCCCAGTCCACCCTCAACTTAGCCAGGCCAGACTTTA
GGGCTGAAGCCAAATTGGAAGTGTCCTCCTCATGTGGACCCCAGTGTCACAAGGGAACACCTCT
GCCCACATATGAAGAGGCCAAACAATACCTGTCTTATGAGACACTCTATTCCAATGGCAGCCGC
ACAGAGACTCAGGTGGGCATTTACATCCTCAGCAATGGCAGAGGTGGAGCTCAACACCAAGACT
CTGAGTCTTCAGGAAAGTCTCGGAGGAAGCGGCAGATTTATGGCTATGACAGCAGGTTCAGCAT
TTTTGGGAAGGACTTCCTACTTAACTACCCTTTCTCAACATCAGTGAAGTTATCTACAGGCTGC
ACTGGCACTCTGGTAGCAGAGAAACACGTCCTCACAGCTGCCCACTGCATACATGATGGGAAAA
CCTATGTGAAAGGAACGCAGAAACTTCGAGTGGGCTTCCTGAAGCCCAAGTTTAAAGATGGCGG
TCGAGGGGCCAACAGCTCCAGCTCAGCCTTGCCTGAGAAGATGAAATTTCAGTGGATCCGGGTA
AAACGCACCCATGTGCCCAAGGGTTGGATCAAAGGCAATGCCAATGATATTGGCATGGATTATG
ACTATGCCCTCTTGGAACTCAAAAAACCCCACAAGAGAAAGTTCATGAAGATTGGGGTGAGCCC
TCCTGCTAAACAGCTGCCAGGAGGCAGAATTCACTTCTCTGGCTATGACAATGATCGACCTGGC
AATTTGGTGTACCGCTTCTGTGATGTCAAAGATGAGACCTATGACCTGCTTTACCAGCAGTGTG
ATGCTCAGCCTGGGGCCAGTGGGTCAGGGGTCTATGTGAGGATGTGGAAGAGACAGCAGCAAAA
GTGGGAGAGAAAAATTATTGGCATCTTTTCAGGACACCAGTGGGTGGACATGAATGGTTCTCCA
CAGGATTTTAATGTGGCTGTTAGAATCACCCCTCTCAAATATGCTCAGATTTGCTACTGGATTA
AAGGAAACTACCTGGACTGTAGGGAGGGGTGATACAGTGCTCCCTCCTGGCAGCACTTAATAGT
CTTCATGTACTCATTGTAAGAGAAACCAAATTTTATCATTGTCTCATGCATGCACACACACACA
TGTGTCTGTGTGTGTGTGATGTGTCACGTAACATCCTTTACCTAATTTCTTAAAATTGTAGGAT
GACTGGCTTTATTATTTGAAAACTGGTTTGTGTATCATATCATTTAAGAAGTTTGAAAGCATAC
TTTTGCATAGAAGTAAAAATCAATACTGATGTTTGGGGCAATAGGAAATATTTGACAATTAAGT
TAATCATTCACTTTTTTTGAGAACATTGGATTTTATTTCATCTGAACTTGTTTCAAAGGTTTAT
ATTAAATATGTGGCATACAGGAGATATGAATTCTTGTGTGTGTATGTGTTTTCTTCAGAGATTT
ATATCTTTATATTTTAAAAATTCTTGATTATTAAAGCTTCCAGATGGTAGTATGTCCATCACAT
ATAACTCTTAGGAATTTCACAATACTTCTTAGGCAGTTATAATATTTTGGATTTGGAGGCATTC
ACATGTTAGTCCTTGAACAGTAAAATAAATAATTTATTGGCTCTGTTAATATACATGTTCAACT
ACATCTAAAAATAAACTGGCACCCCAAGCTACTTTTAGTTTTGAAAATGGTTTCTCTTCCAAAG
ACTGTCACTCTACTTTGTGGGAAGTCTTTGCTTATGGTTCTGCCAGTTTTGTAGACACAGCAGA
GTAGGCAAGCTCGTTTATCCAATGATCACTTAGCAGATTTCACTCACATTTCTAGAGCTAGTTG
TTTTGCAAAGACTATAATCAGGGTCTAATTAGAACAGGCTGTATTGCCTCTCTACTCACAGTTG
TGGTCGGAATAAAAACAATCATAGCATTTTGCCCCTGGAGTGTAGCATGTCTCATGTTTTATCA
TTTGGATGGAGTAATTTAAAATGAATTAAATTCCAGAGAACAATGGATGCATTGCTCGGCAGAT
GTCACAACAGAATAACCACTTGTTTGAAGCCTGGCACAGTCACATAGCCTAATCAAAATTTATT
TCTGCATAGTTTTCAATGTGCTTTTGGAGAGTTGTGTACTTGCTCAATCTGGAAACTTTTCTGT
CTTGTTGTAATTACTTTATAGTAAAATTACTTGTCATTTGCTTTAAGAAAAACCAGTATGACTT
TTTCTTCCCCTGGCTTTAAAAGGATCCCTGTTGGTGGAATGTTCTGGACTGGAGGCTTGTGTAG
TCAGGGACAATAATAAAAATGAAAATTGAGAGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005323353	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000006636.2
GenBank Protein	KAG3286311	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005323353 ⟸ XM_005323296

- UniProtKB:

I3M9P7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEIPGLLFLLLLLCVVGQVSPYGAFWKPTWPAYRLPVVLPQSTLNLARPDFRAEAKLEVSSSC
GPQCHKGTPLPTYEEAKQYLSYETLYSNGSRTETQVGIYILSNGRGGAQHQDSESSGKSRRKRQ
IYGYDSRFSIFGKDFLLNYPFSTSVKLSTGCTGTLVAEKHVLTAAHCIHDGKTYVKGTQKLRVG
FLKPKFKDGGRGANSSSSALPEKMKFQWIRVKRTHVPKGWIKGNANDIGMDYDYALLELKKPHK
RKFMKIGVSPPAKQLPGGRIHFSGYDNDRPGNLVYRFCDVKDETYDLLYQQCDAQPGASGSGVY
VRMWKRQQQKWERKIIGIFSGHQWVDMNGSPQDFNVAVRITPLKYAQICYWIKGNYLDCREG

hide sequence

RefSeq Acc Id:

ENSSTOP00000006636 ⟸ ENSSTOT00000007428

Protein Domains

Peptidase S1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000007434	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000007428.3	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
InterPro	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
NCBI Gene	Prss23	ENTREZGENE
PANTHER	SERINE PROTEASE	UniProtKB/TrEMBL
	SERINE PROTEASE 23	UniProtKB/TrEMBL
Pfam	Trypsin	UniProtKB/TrEMBL
PROSITE	TRYPSIN_HIS	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
UniProt	I3M9P7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-23	Prss23	serine protease 23		protease, serine 23	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD