Hrc (histidine rich calcium binding protein)

Gene: Hrc (histidine rich calcium binding protein) Ictidomys tridecemlineatus

Analyze

Symbol:

Hrc

Name:

histidine rich calcium binding protein

RGD ID:

12558753

Description:

ENCODES a protein that exhibits ATPase binding (inferred); calcium ion binding (inferred); transmembrane transporter binding (inferred); INVOLVED IN calcium ion homeostasis (ortholog); negative regulation of calcium ion import into sarcoplasmic reticulum (ortholog); negative regulation of cytosolic calcium ion concentration (ortholog); ASSOCIATED WITH Body Weight (ortholog); Brugada syndrome (ortholog); Cardiac Fibrosis (ortholog); FOUND IN sarcoplasmic reticulum membrane (inferred); Z disc (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	21,470,024 - 21,473,846 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936664	3,083,602 - 3,092,308 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936664	3,088,072 - 3,092,034 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Body Weight (ISO)

Brugada syndrome (ISO)

Cardiac Fibrosis (ISO)

Cardiomegaly (ISO)

developmental and epileptic encephalopathy 12 (ISO)

genetic disease (ISO)

progressive familial heart block (ISO)

Progressive Familial Heart Block Type I (ISO)

progressive familial heart block type IA (ISO)

progressive familial heart block type IB (ISO)

Sudden Unexpected Nocturnal Death Syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion homeostasis (IEA,ISO)

negative regulation of calcium ion import into sarcoplasmic reticulum (ISO)

negative regulation of cytosolic calcium ion concentration (ISO)

positive regulation of heart contraction (IEA)

positive regulation of heart rate (IEA)

positive regulation of relaxation of cardiac muscle (IEA)

regulation of calcium ion transmembrane transport (IEA)

regulation of cell communication by electrical coupling involved in cardiac conduction (IEA)

regulation of cytosolic calcium ion concentration (IEA)

regulation of heart contraction (IEA,ISO)

regulation of heart rate (IEA)

regulation of peptidyl-serine phosphorylation (IEA)

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (IEA)

Cellular Component

sarcoplasmic reticulum membrane (IEA)

Z disc (IEA)

Molecular Function

ATPase binding (IEA)

calcium ion binding (IEA)

protein binding (ISO)

transmembrane transporter binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Hrc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	21,470,024 - 21,473,846 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936664	3,083,602 - 3,092,308 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936664	3,088,072 - 3,092,034 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HRC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	49,151,198 - 49,155,396 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	49,151,198 - 49,155,396 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	49,654,455 - 49,658,653 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	54,346,267 - 54,350,493 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	54,346,269 - 54,350,476	NCBI
Celera	19	46,521,679 - 46,525,908 (-)	NCBI		Celera
Cytogenetic Map	19	q13.33	NCBI
HuRef	19	46,030,689 - 46,034,918 (-)	NCBI		HuRef
CHM1_1	19	49,656,583 - 49,660,812 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	52,145,932 - 52,150,133 (-)	NCBI		T2T-CHM13v2.0

Hrc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	44,984,693 - 44,988,397 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	44,984,714 - 44,988,398 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	45,335,269 - 45,338,973 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	45,335,290 - 45,338,974 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	52,590,639 - 52,594,343 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	45,203,443 - 45,207,015 (+)	NCBI		MGSCv36	mm8
Celera	7	40,791,527 - 40,795,231 (+)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	29.26	NCBI

Hrc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	104,949,750 - 104,953,475 (+)	NCBI		GRCr8
mRatBN7.2	1	95,813,262 - 95,816,987 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	95,813,253 - 95,816,984 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	101,198,707 - 101,202,429 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	109,671,382 - 109,675,104 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	102,961,782 - 102,965,504 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	101,324,788 - 101,328,391 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	101,324,652 - 101,328,435 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	102,388,311 - 102,391,914 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	95,805,143 - 95,808,746 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	95,883,253 - 95,886,857 (+)	NCBI
Celera	1	90,069,730 - 90,073,333 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

Hrc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955559	1,583,876 - 1,587,355 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955559	1,583,661 - 1,587,457 (+)	NCBI	ChiLan1.0	ChiLan1.0

HRC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	55,266,107 - 55,270,451 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	57,185,639 - 57,189,978 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	46,162,231 - 46,166,606 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	55,089,281 - 55,093,689 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	55,089,384 - 55,093,463 (-)	Ensembl	panpan1.1		panPan2

HRC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	107,304,718 - 107,308,741 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	107,304,924 - 107,308,740 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	106,892,417 - 106,896,448 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	107,829,579 - 107,833,610 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	107,811,395 - 107,833,766 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	107,497,676 - 107,501,707 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	107,143,909 - 107,147,940 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	107,979,496 - 107,983,527 (+)	NCBI		UU_Cfam_GSD_1.0

HRC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	54,337,347 - 54,341,625 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	54,337,348 - 54,341,638 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	49,986,764 - 49,990,919 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HRC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	42,372,758 - 42,378,273 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	42,372,861 - 42,377,267 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	22,265,945 - 22,271,134 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hrc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624832	4,938,074 - 4,941,578 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005336660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000026621 ⟹ ENSSTOP00000022748

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936664	3,083,602 - 3,092,308 (-)	Ensembl

RefSeq Acc Id:

XM_005336660 ⟹ XP_005336717

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	21,470,024 - 21,473,846 (-)	NCBI
SpeTri2.0	NW_004936664	3,088,072 - 3,092,034 (-)	NCBI

Sequence:

show sequence

GGGTCTGGGACTCCAGAGACAGCCTCAGAGGGGTGTCCAGGGCAGAGAAAGGCAAACGGACAGA
GATCAAGAGAGAAAAAGTGAAGGAGAGACACAGAGAAAGAGTCAGACCCAGAAGGGGACAGGAC
CCCAACCTTGATCACACAGCCTCAGAGGCAGCTGGAGCCAGCCCTGGGAGAAAGCCTGCTGCCT
AAACGTCCCCATGGGCCACCCTGGGCCATGGCTGCACACTTCTCTCCTCTGCGCCGCAGTGGTC
AGCCTGCTCCTCCCTCCTGCCATGACCCAGCAGCTGAGAGGGGCTGGGCTGGGCCCCAGCAACT
GGAACAACAATGCAAACGTGGCAGGGCCCTCAGAGGACGCGTCGGCCGAGGTTAGCCACCGGAT
CTACAGCCACGGAGGCCACCGAGATGAGAGTGAGGATGTTTCCACAGAAAATGGGCATCATTTC
CACAGTCATAGAGACCAGAGAGGGGAGGATAAGGATGTCTCCAGGGATTATGGCCACCAGCACG
GAGCCCACAGGTACCAAGGCCAAGAGCTTACAGATGGGCATGTCTCAGAGGAGGTCTTCACAGA
GCAGGCTGAGCAAGCCCACGGGCACAGAGGCCATGACGAGGAAGACGCAGGGGACTCAGCCGAG
CATGAGAACCACTTCCCCAGCCACAGGAGCCACAGCGATGAAGATGAGGACGAGGATGACATTG
TATCCAGTGAGCATCACCATCGCAGCCCCAGGCATGTGCACCGGGGTCCTCGAGAGGGAGAGGA
TGATGAAGGAGAAGAGGAAGAAGAGGAGGAAGGGGAGGAGGAAGTCTCCTCTGAGTCTAGGTAC
CAGGGCCACAGGCATCAAGGCCATGGCAGTGAGGAGGAGGAGGACATCTCAGATGAATACCACC
ATCATGTCCCTGACCATGGGCACCAAGGCCACAAAGAAGAAGAAGATGATGATGATGATGATGA
TGATGATGATGTCTCCGCTGAGTATGGACACCAGACCCACAGGCACCGAGGCCACGGGAATGAA
GAGGAGGAGGACATTTCAGATGAACACCACCCTCATGTCCCCAGCCATGGACATGGAGATCACG
AAGAAGATGATGATGTTTCTATTGAGTCTGGACACCAGGCCCACAGGCACCGAGGCCACGGGAA
TGAAGAGGAGGACGTCTCAGATGAACACCACCATCATGTCACTGGCCATGGGCACCAAGGCCAC
AGAGACAAGGAAGATGAAGATGAGGACGTGTCCACTGAGCATTGGCACCAGTTTCCCAGACATG
GCCACCATGGCCTTGGGGACAAGAATGAGGAAGAGGAGGAGGAGGTCATAGACAAGCTCAGCCA
ACATGTTGCAAGGCACCAACCCCAAGGCCACAAGAGCGATGAGGAGGAGGACTTCCCAGAGGAG
TATAAAACAGACGTCCCTGTCCATCACCACCCTGGCGTTTCAAAGGAGGAAGATGAGGACATCT
CTGCCGAGCTTGGCCACCAGGCCCCCAGCCACAGGGAACAAGACCACCAAGATGAAGGGACTGA
TCATGGTCACAGAGGATCCATTCAAGAGGAGATTAGTCATCACTCCCCAGAGCACATGCAGGTT
GGGAGGGAGAGTGACTCGGGAGAGGAAGAGGATGACAGCTCCCGGGAGGGAGAGGATGAAGGCT
CTGAGCAGGGGGTGGAAGAAGCCCACCACCTGGCCCAGGAAGACCAGCAGGACGAAGAGGAAGG
TCACGGCCTCAGCCTGAGCCAGGAGGAAGAAGGGGAGGAAGATGAGGAGGAGCAAGAAGACAGG
AGGGAAGAGAGGGCTGAATTTCTGGTCCCACCGAGCCAAGATCACAGAAAAGAGGAGGAGGAGG
AGGAGGAAGGCTTAGAGGAAGATGAGCTCCCCTTCACCATCATCCCTAACCCCCTGGCCAGTAG
GGAGGTGGCTGGGGATGGCTCTAGTGAGGAGGAGAGTGGTGAAGACACAGGTCTGCAGGACACC
CAGGAATATGGGAATTATCAACCAGGGTCCCTGTGTGGCTACTGCACCTTCTGTAATCGATGCA
CTGAATGTGAGAACTGTCACTGTGACGAGGAGAACATGGGAGAACACTGCGACCAGTGCCAGCA
CTGCCAGTTCTGCTATCTCTGCCCTCTAGTCTGCGAAACTCTGTGCACTCCAGGAAGCTACGTC
GACTACTTCTCCTCCTCCCTGTATCAAGCCCTGGCAGACATGCTGGAAACTCCGGAACCCTGAC
CTGGTCGCGCGGCTGCATCGCATATGGACCTCCCCCTGCCCTCCGCCCCTAACCACGAGCCATA
TTTATTTCTCTGAATAAACGTGCTCCCCGAAACCTCATTTTCAGACCTGGGGTCGATTCTCAGA
GCTCCAGGGAACATGGGTGGGGGGAAAGCCTGTGGGAGAAAGGGGTTGGACTTTTGGGTCCTCC
GAGGGAGTTTTTTTCTTAAAGTCCTGACCCCCCCACACACCACCACCAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005336717	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022748.1
GenBank Protein	KAG3256477	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005336717 ⟸ XM_005336660

- UniProtKB:

I3NEF1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGHPGPWLHTSLLCAAVVSLLLPPAMTQQLRGAGLGPSNWNNNANVAGPSEDASAEVSHRIYSH
GGHRDESEDVSTENGHHFHSHRDQRGEDKDVSRDYGHQHGAHRYQGQELTDGHVSEEVFTEQAE
QAHGHRGHDEEDAGDSAEHENHFPSHRSHSDEDEDEDDIVSSEHHHRSPRHVHRGPREGEDDEG
EEEEEEEGEEEVSSESRYQGHRHQGHGSEEEEDISDEYHHHVPDHGHQGHKEEEDDDDDDDDDD
VSAEYGHQTHRHRGHGNEEEEDISDEHHPHVPSHGHGDHEEDDDVSIESGHQAHRHRGHGNEEE
DVSDEHHHHVTGHGHQGHRDKEDEDEDVSTEHWHQFPRHGHHGLGDKNEEEEEEVIDKLSQHVA
RHQPQGHKSDEEEDFPEEYKTDVPVHHHPGVSKEEDEDISAELGHQAPSHREQDHQDEGTDHGH
RGSIQEEISHHSPEHMQVGRESDSGEEEDDSSREGEDEGSEQGVEEAHHLAQEDQQDEEEGHGL
SLSQEEEGEEDEEEQEDRREERAEFLVPPSQDHRKEEEEEEEGLEEDELPFTIIPNPLASREVA
GDGSSEEESGEDTGLQDTQEYGNYQPGSLCGYCTFCNRCTECENCHCDEENMGEHCDQCQHCQF
CYLCPLVCETLCTPGSYVDYFSSSLYQALADMLETPEP

hide sequence

RefSeq Acc Id:

ENSSTOP00000022748 ⟸ ENSSTOT00000026621

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000021781	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000026621.2	UniProtKB/TrEMBL
InterPro	Hist_rich_Ca-bd	UniProtKB/TrEMBL
	HRC	UniProtKB/TrEMBL
NCBI Gene	Hrc	ENTREZGENE
PANTHER	PTHR15054	UniProtKB/TrEMBL
	SARCOPLASMIC RETICULUM HISTIDINE-RICH CALCIUM-BINDING PROTEIN	UniProtKB/TrEMBL
Pfam	Hist_rich_Ca-bd	UniProtKB/TrEMBL
UniProt	I3NEF1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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