LOC101964770 (C-C chemokine receptor type 2) - Rat Genome Database

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Pathways
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Gene: LOC101964770 (C-C chemokine receptor type 2) Ictidomys tridecemlineatus
Analyze
Symbol: LOC101964770 (Ensembl: CCR2)
Name: C-C chemokine receptor type 2
RGD ID: 12558344
Description: ENCODES a protein that exhibits C-C chemokine binding (inferred); C-C chemokine receptor activity (inferred); CCR2 chemokine receptor binding (inferred); INVOLVED IN blood vessel remodeling (inferred); calcium-mediated signaling (inferred); cell chemotaxis (inferred); FOUND IN cytoplasm (inferred); external side of plasma membrane (inferred); fibrillar center (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ccr2; chemokine (C-C motif) receptor 2
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,731,415 - 200,738,692 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936596285,559 - 286,680 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936596285,559 - 287,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel remodeling  (IEA)
calcium-mediated signaling  (IEA)
cell chemotaxis  (IEA)
cellular defense response  (IEA)
cellular homeostasis  (IEA)
chemokine-mediated signaling pathway  (IEA)
chemotaxis  (IEA)
cytokine-mediated signaling pathway  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
hemopoiesis  (IEA)
homeostasis of number of cells within a tissue  (IEA)
humoral immune response  (IEA)
immune response  (IEA)
inflammatory response  (IEA)
inflammatory response to wounding  (IEA)
leukocyte adhesion to vascular endothelial cell  (IEA)
macrophage migration  (IEA)
monocyte chemotaxis  (IEA)
monocyte extravasation  (IEA)
negative regulation of angiogenesis  (IEA)
negative regulation of eosinophil degranulation  (IEA)
negative regulation of type 2 immune response  (IEA)
neutrophil clearance  (IEA)
positive regulation of alpha-beta T cell proliferation  (IEA)
positive regulation of astrocyte chemotaxis  (IEA)
positive regulation of CD8-positive, alpha-beta T cell extravasation  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of hematopoietic stem cell migration  (IEA)
positive regulation of immune complex clearance by monocytes and macrophages  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-2 production  (IEA)
positive regulation of leukocyte tethering or rolling  (IEA)
positive regulation of monocyte chemotaxis  (IEA)
positive regulation of monocyte extravasation  (IEA)
positive regulation of synaptic transmission, glutamatergic  (IEA)
positive regulation of T cell activation  (IEA)
positive regulation of T cell chemotaxis  (IEA)
positive regulation of T-helper 1 type immune response  (IEA)
positive regulation of thymocyte migration  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type II interferon production  (IEA)
regulation of inflammatory response  (IEA)
regulation of macrophage migration  (IEA)
regulation of mononuclear cell migration  (IEA)
regulation of T cell cytokine production  (IEA)
regulation of T cell differentiation  (IEA)
regulation of T cell migration  (IEA)
regulation of vascular endothelial growth factor production  (IEA)
sensory perception of pain  (IEA)
signal transduction  (IEA)
T-helper 17 cell chemotaxis  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005332914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000001669   ⟹   ENSSTOP00000001496
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936596285,559 - 286,680 (+)Ensembl
RefSeq Acc Id: XM_005332914   ⟹   XP_005332971
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118200,731,415 - 200,738,692 (+)NCBI
SpeTri2.0NW_004936596285,559 - 287,198 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005332971 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000001496.2
GenBank Protein KAG3279777 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005332971   ⟸   XM_005332914
- UniProtKB: I3LZ09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000001496   ⟸   ENSSTOT00000001669
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001677 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001669.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Chemokine_CCR2 UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene LOC101964770 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR TYPE 2 UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS CCCHEMOKINER UniProtKB/TrEMBL
  CHEMOKINER2 UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt I3LZ09 ENTREZGENE, UniProtKB/TrEMBL