Mmp11 (matrix metallopeptidase 11) - Rat Genome Database

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Gene: Mmp11 (matrix metallopeptidase 11) Ictidomys tridecemlineatus
Analyze
Symbol: Mmp11
Name: matrix metallopeptidase 11
RGD ID: 12556975
Description: ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN basement membrane organization (ortholog); collagen catabolic process (ortholog); collagen fibril organization (ortholog); ASSOCIATED WITH agammaglobulinemia 2 (ortholog); Coffin-Siris syndrome 3 (ortholog); epilepsy (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: matrix metallopeptidase 11 (stromelysin 3); stromelysin-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,433,947 - 141,443,698 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,310,846 - 1,320,062 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,309,013 - 1,320,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mmp11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,433,947 - 141,443,698 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,310,846 - 1,320,062 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,309,013 - 1,320,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,772,849 - 23,784,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,768,226 - 23,784,316 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,115,036 - 24,126,503 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,445,036 - 22,456,503 (+)NCBINCBI36Build 36hg18NCBI36
Build 342222,439,589 - 22,451,056NCBI
Celera227,954,127 - 7,965,595 (+)NCBICelera
Cytogenetic Map22q11.23ENTREZGENE
HuRef227,103,103 - 7,114,555 (+)NCBIHuRef
CHM1_12224,127,275 - 24,138,742 (+)NCBICHM1_1
T2T-CHM13v2.02224,220,041 - 24,231,509 (+)NCBIT2T-CHM13v2.0
Mmp11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,759,056 - 75,768,336 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,759,056 - 75,772,330 (-)EnsemblGRCm39 Ensembl
GRCm381075,923,221 - 75,932,502 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,923,222 - 75,936,496 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,385,969 - 75,395,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,366,940 - 75,376,179 (-)NCBIMGSCv36mm8
Celera1076,967,909 - 76,977,148 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.62NCBI
Mmp11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,730,284 - 12,739,067 (+)NCBIGRCr8
mRatBN7.22012,730,846 - 12,739,629 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,730,836 - 12,739,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,437,476 - 13,446,257 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,798,397 - 12,807,178 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,270,190 - 13,278,971 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,670,051 - 13,678,834 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,670,066 - 13,678,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,825,614 - 15,834,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,129,667 - 13,138,449 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,129,893 - 13,138,676 (+)NCBI
Celera2014,222,131 - 14,230,914 (+)NCBICelera
Cytogenetic Map20p12NCBI
Mmp11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,459,428 - 8,469,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,458,622 - 8,464,037 (-)NCBIChiLan1.0ChiLan1.0
MMP11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22333,504,434 - 33,515,963 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12236,240,937 - 36,252,465 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,528,639 - 4,540,118 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,610,626 - 22,625,335 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,615,969 - 22,624,567 (+)Ensemblpanpan1.1panPan2
MMP11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,730,173 - 28,741,506 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,727,332 - 28,741,415 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,804,212 - 27,813,598 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,135,355 - 30,147,019 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,135,354 - 30,146,606 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,217,197 - 28,226,583 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,835,130 - 27,844,514 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,823,000 - 28,832,388 (-)NCBIUU_Cfam_GSD_1.0
MMP11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,907,687 - 49,912,617 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,907,684 - 49,917,494 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,349,978 - 53,359,794 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,889,343 - 6,900,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,889,385 - 6,899,788 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666100472,421 - 483,648 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,398,130 - 10,408,376 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474710,398,167 - 10,408,397 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000008225   ⟹   ENSSTOP00000007368
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366191,310,846 - 1,320,062 (-)Ensembl
RefSeq Acc Id: XM_005334473   ⟹   XP_005334530
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118141,433,950 - 141,443,698 (+)NCBI
SpeTri2.0NW_0049366191,309,013 - 1,320,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040289303   ⟹   XP_040145237
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118141,434,150 - 141,443,698 (+)NCBI
RefSeq Acc Id: XM_040289304   ⟹   XP_040145238
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118141,433,949 - 141,443,698 (+)NCBI
RefSeq Acc Id: XM_040289305   ⟹   XP_040145239
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118141,433,947 - 141,441,971 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005334530 (Get FASTA)   NCBI Sequence Viewer  
  XP_040145237 (Get FASTA)   NCBI Sequence Viewer  
  XP_040145238 (Get FASTA)   NCBI Sequence Viewer  
  XP_040145239 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000007368.3
GenBank Protein KAG3278766 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005334530   ⟸   XM_005334473
- Peptide Label: isoform X1
- UniProtKB: I3MB90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040145239   ⟸   XM_040289305
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040145238   ⟸   XM_040289304
- Peptide Label: isoform X3
- UniProtKB: I3MB90 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040145237   ⟸   XM_040289303
- Peptide Label: isoform X2
- UniProtKB: I3MB90 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000007368   ⟸   ENSSTOT00000008225
Protein Domains
Peptidase metallopeptidase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008225 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008225.3 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/TrEMBL
  M10A_MMP UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/TrEMBL
  Pept_M10A UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
NCBI Gene Mmp11 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/TrEMBL
  PTHR10201:SF20 UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/TrEMBL
PIRSF Peptidase_M10A_matrix UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/TrEMBL
SMART SM00120 UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF50923 UniProtKB/TrEMBL
UniProt I3MB90 ENTREZGENE, UniProtKB/TrEMBL