Arhgef1 (Rho guanine nucleotide exchange factor 1) - Rat Genome Database

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Gene: Arhgef1 (Rho guanine nucleotide exchange factor 1) Ictidomys tridecemlineatus
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Symbol: Arhgef1
Name: Rho guanine nucleotide exchange factor 1
RGD ID: 12554580
Description: ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN microtubule depolymerization (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ASSOCIATED WITH Carpenter Syndrome 2 (ortholog); congenital hypoplastic anemia (ortholog); craniosynostosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Rho guanine nucleotide exchange factor 1, transcript variant X1; Rho guanine nucleotide exchange factor 1, transcript variant X2; Rho guanine nucleotide exchange factor 1, transcript variant X3; Rho guanine nucleotide exchange factor 1, transcript variant X4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,193,641 - 16,211,488 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706540,748 - 558,823 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706540,987 - 558,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
membrane  (IEA)
plasma membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Arhgef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,193,641 - 16,211,488 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706540,748 - 558,823 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706540,987 - 558,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,883,184 - 41,930,141 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,883,173 - 41,930,150 (+)EnsemblGRCh38hg38GRCh38
GRCh371942,387,251 - 42,434,293 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,079,107 - 47,103,444 (+)NCBINCBI36Build 36hg18NCBI36
Build 341947,080,285 - 47,103,443NCBI
Celera1939,186,950 - 39,211,282 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,818,551 - 38,842,545 (+)NCBIHuRef
CHM1_11942,388,735 - 42,412,987 (+)NCBICHM1_1
T2T-CHM13v2.01944,702,671 - 44,749,424 (+)NCBIT2T-CHM13v2.0
Arhgef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,601,762 - 24,626,019 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,602,337 - 24,626,019 (+)EnsemblGRCm39 Ensembl
GRCm38724,902,986 - 24,926,594 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,902,912 - 24,926,594 (+)EnsemblGRCm38mm10GRCm38
MGSCv37725,688,005 - 25,711,611 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,611,816 - 24,635,352 (+)NCBIMGSCv36mm8
Celera719,518,885 - 19,542,623 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.52NCBI
Arhgef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,626,884 - 89,648,823 (+)NCBIGRCr8
mRatBN7.2180,499,026 - 80,520,954 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,499,131 - 80,520,953 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,891,659 - 85,913,491 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,442,476 - 94,464,309 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,647,420 - 87,669,252 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,769,212 - 81,797,237 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,779,380 - 81,797,236 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,025,520 - 83,053,989 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,209,459 - 80,226,353 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,287,569 - 80,304,463 (+)NCBI
Celera174,946,561 - 74,968,150 (+)NCBICelera
Cytogenetic Map1q21NCBI
Arhgef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955555941,539 - 961,407 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,988,151 - 48,013,022 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,857,135 - 49,882,019 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,771,343 - 38,796,174 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,276,407 - 47,299,663 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,277,420 - 47,299,663 (+)Ensemblpanpan1.1panPan2
ARHGEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,391,670 - 112,410,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,827,451 - 111,846,482 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,015,057 - 113,034,087 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,015,059 - 113,033,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,568,393 - 112,587,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,204,579 - 112,223,608 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,131,063 - 113,150,095 (-)NCBIUU_Cfam_GSD_1.0
ARHGEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,975,876 - 49,995,339 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,975,957 - 49,995,442 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,030,643 - 46,046,982 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,091,158 - 36,115,355 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,091,204 - 36,115,626 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607314,326,794 - 14,351,774 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907783,214 - 802,150 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624907783,404 - 802,205 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000003545   ⟹   ENSSTOP00000003175
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936706540,748 - 558,823 (-)Ensembl
RefSeq Acc Id: XM_013364200   ⟹   XP_013219654
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934916,193,644 - 16,211,488 (-)NCBI
SpeTri2.0NW_004936706540,987 - 558,792 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013364201   ⟹   XP_013219655
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934916,193,641 - 16,204,677 (-)NCBI
SpeTri2.0NW_004936706540,991 - 552,027 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021735163   ⟹   XP_021590838
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934916,193,641 - 16,211,488 (-)NCBI
SpeTri2.0NW_004936706540,991 - 558,792 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021735164   ⟹   XP_021590839
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934916,193,641 - 16,211,488 (-)NCBI
SpeTri2.0NW_004936706541,032 - 558,792 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040278827   ⟹   XP_040134761
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934916,193,641 - 16,208,355 (-)NCBI
RefSeq Acc Id: XM_040278828   ⟹   XP_040134762
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934916,194,573 - 16,211,488 (-)NCBI
RefSeq Acc Id: XP_013219654   ⟸   XM_013364200
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013219655   ⟸   XM_013364201
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_021590838   ⟸   XM_021735163
- Peptide Label: isoform X1
- UniProtKB: I3M2H1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021590839   ⟸   XM_021735164
- Peptide Label: isoform X1
- UniProtKB: I3M2H1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040134761   ⟸   XM_040278827
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040134762   ⟸   XM_040278828
- Peptide Label: isoform X3
RefSeq Acc Id: ENSSTOP00000003175   ⟸   ENSSTOT00000003545
Protein Domains
DH   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003526 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003545.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  p115RhoGEF_RGS UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_16 UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  RGS-like_dom UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/TrEMBL
NCBI Gene Arhgef1 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D UniProtKB/TrEMBL
Pfam PH_16 UniProtKB/TrEMBL
  RGS-like UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF48097 UniProtKB/TrEMBL
UniProt I3M2H1 ENTREZGENE, UniProtKB/TrEMBL