Npas2 (neuronal PAS domain protein 2) - Rat Genome Database

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Gene: Npas2 (neuronal PAS domain protein 2) Ictidomys tridecemlineatus
Analyze
Symbol: Npas2
Name: neuronal PAS domain protein 2
RGD ID: 12553565
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); E-box binding (inferred); INVOLVED IN circadian rhythm (ortholog); circadian sleep/wake cycle (ortholog); locomotor rhythm (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Chronobiology Disorders (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN CLOCK-BMAL transcription complex (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuronal PAS domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629286,320,820 - 86,473,227 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493666195,752 - 210,097 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493666196,312 - 176,395 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Npas2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629286,320,820 - 86,473,227 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493666195,752 - 210,097 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493666196,312 - 176,395 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPAS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382100,818,723 - 100,996,829 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2100,820,139 - 100,996,829 (+)EnsemblGRCh38hg38GRCh38
GRCh372101,436,601 - 101,613,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362100,803,045 - 100,979,719 (+)NCBINCBI36Build 36hg18NCBI36
Build 342100,895,130 - 101,071,805NCBI
Celera295,641,227 - 95,817,201 (+)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef295,284,890 - 95,377,330 (+)NCBIHuRef
CHM1_12101,440,965 - 101,617,609 (+)NCBICHM1_1
T2T-CHM13v2.02101,278,833 - 101,455,526 (+)NCBIT2T-CHM13v2.0
Npas2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39139,233,013 - 39,402,321 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl139,232,812 - 39,402,317 (+)EnsemblGRCm39 Ensembl
GRCm38139,193,702 - 39,363,240 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl139,193,731 - 39,363,236 (+)EnsemblGRCm38mm10GRCm38
MGSCv37139,251,117 - 39,420,085 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36139,138,745 - 39,306,732 (+)NCBIMGSCv36mm8
Celera138,989,171 - 39,157,180 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map117.98NCBI
Npas2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8948,959,225 - 49,138,036 (+)NCBIGRCr8
mRatBN7.2941,463,361 - 41,642,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,463,830 - 41,642,320 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx949,959,731 - 50,138,286 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0955,082,477 - 55,261,036 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0953,364,568 - 53,543,046 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0945,901,262 - 46,081,880 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl945,901,741 - 46,081,880 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0945,590,021 - 45,769,792 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4938,255,362 - 38,434,352 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1938,256,775 - 38,434,671 (+)NCBI
Celera939,213,508 - 39,392,002 (+)NCBICelera
Cytogenetic Map9q22NCBI
Npas2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554706,831,992 - 6,905,679 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554706,826,541 - 6,906,814 (+)NCBIChiLan1.0ChiLan1.0
NPAS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21227,229,065 - 27,405,686 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A27,231,826 - 27,408,436 (-)NCBINHGRI_mPanPan1
PanPan1.12A101,868,932 - 101,972,923 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A101,868,933 - 101,972,866 (+)Ensemblpanpan1.1panPan2
NPAS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11041,846,766 - 42,005,058 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1041,847,625 - 42,005,469 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1041,771,932 - 41,930,470 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01042,714,471 - 42,873,104 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1042,714,474 - 42,845,094 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11042,426,223 - 42,584,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01042,709,720 - 42,868,321 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01042,901,258 - 43,060,042 (-)NCBIUU_Cfam_GSD_1.0
NPAS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl353,298,811 - 53,490,574 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1353,298,805 - 53,490,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2355,845,037 - 56,037,026 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPAS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1144,529,048 - 4,705,167 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl144,612,225 - 4,705,419 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041172,148,777 - 172,325,348 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npas2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247495,636,782 - 5,790,779 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247495,636,878 - 5,790,670 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000008943   ⟹   ENSSTOP00000008016
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493666195,752 - 210,097 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000038390   ⟹   ENSSTOP00000024542
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936661143,597 - 210,097 (-)Ensembl
RefSeq Acc Id: XM_021733971   ⟹   XP_021589646
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629286,320,823 - 86,473,227 (+)NCBI
SpeTri2.0NW_00493666196,312 - 176,395 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040270804   ⟹   XP_040126738
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629286,409,792 - 86,473,227 (+)NCBI
RefSeq Acc Id: XM_040270805   ⟹   XP_040126739
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629286,409,792 - 86,473,227 (+)NCBI
RefSeq Acc Id: XM_040270806   ⟹   XP_040126740
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629286,320,820 - 86,473,227 (+)NCBI
RefSeq Acc Id: XM_040270807   ⟹   XP_040126741
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629286,410,138 - 86,473,227 (+)NCBI
RefSeq Acc Id: XM_040270808   ⟹   XP_040126742
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629286,417,247 - 86,473,227 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021589646   ⟸   XM_021733971
- Peptide Label: isoform X4
- UniProtKB: I3MCM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040126740   ⟸   XM_040270806
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040126738   ⟸   XM_040270804
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040126739   ⟸   XM_040270805
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040126741   ⟸   XM_040270807
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040126742   ⟸   XM_040270808
- Peptide Label: isoform X6
RefSeq Acc Id: ENSSTOP00000008016   ⟸   ENSSTOT00000008943
RefSeq Acc Id: ENSSTOP00000024542   ⟸   ENSSTOT00000038390
Protein Domains
bHLH   PAS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008934 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008943.3 UniProtKB/TrEMBL
  ENSSTOT00000038390.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  PAS domain UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  CLOCK-like UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Nuc_translocat UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  PAS_fold UniProtKB/TrEMBL
NCBI Gene Npas2 ENTREZGENE
PANTHER CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT UniProtKB/TrEMBL
  NEURONAL PAS DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS_11 UniProtKB/TrEMBL
PRINTS NCTRNSLOCATR UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
UniProt A0A287CTD5_ICTTR UniProtKB/TrEMBL
  I3MCM2 ENTREZGENE, UniProtKB/TrEMBL