Pnpla5 (patatin like phospholipase domain containing 5)

Gene: Pnpla5 (patatin like phospholipase domain containing 5) Ictidomys tridecemlineatus

Analyze

Symbol:

Pnpla5

Name:

patatin like phospholipase domain containing 5

RGD ID:

12553492

Description:

ENCODES a protein that exhibits catalytic activity (inferred); hydrolase activity (inferred); triglyceride lipase activity (inferred); INVOLVED IN lipid catabolic process (inferred); lipid homeostasis (inferred); lipid metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Phelan-McDermid syndrome (ortholog); FOUND IN cytoplasm (inferred); lipid droplet (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

patatin-like phospholipase domain-containing protein 5

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	5,402,413 - 5,411,244 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936718	1,568,339 - 1,577,701 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936718	1,568,339 - 1,577,701 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

intellectual disability (ISO)

Phelan-McDermid syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lipid catabolic process (IEA)

lipid homeostasis (IEA)

lipid metabolic process (IEA)

triglyceride catabolic process (IEA)

Cellular Component

cytoplasm (IEA)

lipid droplet (IEA)

membrane (IEA)

Molecular Function

catalytic activity (IEA)

hydrolase activity (IEA)

protein binding (ISO)

triglyceride lipase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Pnpla5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	5,402,413 - 5,411,244 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936718	1,568,339 - 1,577,701 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936718	1,568,339 - 1,577,701 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PNPLA5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	43,879,678 - 43,892,013 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	43,879,678 - 43,892,013 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	44,275,558 - 44,287,893 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	42,606,891 - 42,619,190 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	42,600,459 - 42,612,758	NCBI
Celera	22	28,186,079 - 28,198,414 (-)	NCBI		Celera
Cytogenetic Map	22	q13.31	NCBI
HuRef	22	27,229,762 - 27,241,992 (-)	NCBI		HuRef
CHM1_1	22	44,233,798 - 44,246,118 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	44,362,256 - 44,374,585 (-)	NCBI		T2T-CHM13v2.0

Pnpla5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	83,996,631 - 84,007,567 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	83,996,557 - 84,007,376 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	84,112,621 - 84,123,175 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	84,112,356 - 84,123,175 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	83,943,051 - 83,953,605 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	83,940,114 - 83,950,941 (-)	NCBI		MGSCv36	mm8
Celera	15	86,242,746 - 86,253,354 (-)	NCBI		Celera
Cytogenetic Map	15	E2	NCBI
cM Map	15	39.78	NCBI

Pnpla5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	117,126,046 - 117,137,036 (-)	NCBI		GRCr8
mRatBN7.2	7	115,246,050 - 115,257,039 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	115,246,050 - 115,257,039 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	116,993,931 - 117,004,916 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	119,219,637 - 119,230,641 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	119,189,103 - 119,200,104 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	124,988,524 - 124,999,137 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	124,988,524 - 124,999,137 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	124,976,939 - 124,987,552 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	122,105,019 - 122,116,003 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	122,132,963 - 122,186,351 (-)	NCBI
Celera	7	111,552,006 - 111,562,981 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

Pnpla5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	28,825,319 - 28,835,751 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	28,825,673 - 28,835,476 (-)	NCBI	ChiLan1.0	ChiLan1.0

PNPLA5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	53,690,774 - 53,720,256 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	56,383,107 - 56,412,675 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	24,753,811 - 24,780,581 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	42,958,161 - 42,972,328 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	42,959,988 - 42,972,328 (-)	Ensembl	panpan1.1		panPan2

PNPLA5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	21,761,069 - 21,773,521 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	21,760,563 - 21,773,531 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	21,701,773 - 21,714,227 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	22,509,933 - 22,522,375 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	22,509,895 - 22,522,385 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	22,229,308 - 22,241,737 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	22,549,389 - 22,561,857 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	22,723,514 - 22,735,949 (+)	NCBI		UU_Cfam_GSD_1.0

PNPLA5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	26,396,040 - 26,408,553 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	26,397,163 - 26,408,126 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	98,996,958 - 99,009,236 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pnpla5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	5,256,060 - 5,266,071 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	5,256,060 - 5,266,061 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005338601	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000024869 ⟹ ENSSTOP00000019753

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936718	1,568,339 - 1,577,701 (-)	Ensembl

RefSeq Acc Id:

XM_005338601 ⟹ XP_005338658

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	5,402,413 - 5,411,244 (+)	NCBI
SpeTri2.0	NW_004936718	1,568,339 - 1,577,701 (-)	NCBI

Sequence:

show sequence

ATGGACTTCTTGGAGGAGGGCAGCTGGAGCCTGTCCTTCGCGGGAGCCGGCTTCCTGGGTCTCT
ACCACGTGGGCGTGACCCAGTGCCTGAGCCAGCGTGCCCCGCGTCTCCTCCAGGGCGCCCGCCG
CTTCTATGGCTCCTCGTCTGGGGCGCTCAATGCCCTCGCCATTGTCTGCGGCAAGTCGACCGAC
TTCTGCTGCTCCCACCTCCTGGACTTGGTCAAGCACGTGGAGGGGCTCAGCCTGGGCATCTTCC
ACCCTGCCTACGCACCCATCGAACACATCAAGCAGCAGCTGCAGGACAAACTGCCAGAGAACAG
CCACATCCTGGCCTCCCAGCGGCTGGGCATCTCGCTGACCCGCTGGCCTGATGGCCACAACTTC
ATAGTCACTGACTTTGCCACCAGAGATGAGCTCATTCAGGCCGTGGTCTGCTCCTTGTACTTCC
CCTTCTACTGTGGGACAATCCCCCCTGAGTTCAGAGGGCAGCGCTACATCGATGGGGCTCTGAG
CAACAATCTGCCCTTCGCGGACTGCCCTTCCACCATCACCGTGTCCCCCTTCCATGGGACAGTG
GACATCTGTCCCCGGAGCTCTTCGGCCAGCCTGCACGAGCTGAATGCTTTCAATGCCAGCTTCC
AAATCTCCACCAAGAACTTCTTCCTGGGGTTCATATCACTCATACCCCCCAAACCTGAGGTGGT
GGCCGACAACTGCAGACAAGGGTACCTGGATGCCCTGAGGTTCCTGGAGGCACGTGGACTCACC
AAGGAGCCCGTGCTGTGGACGTTGGTCTCTAGGGACCCCCCAGCACCCCCTGCTAGGACCCCGG
ACGACGGCACGTCTTTCAACTGCCATGTGCCCACCGTGTTGGTCAAGGACGTGCCCAGCTTGGA
GCAGCTCTCGCCAGAACTGGAGGCTGCACTGAGGAAGGCTGTCAGGAGGGACCTCGGTGCCTGG
GCCCGTTTCCGCCGGTCGGGGCCCGGGCAGGTGCTCTCGTACCTGCTCCTGCCCTGCACGCTGC
CCTTTGAGTATGTGTACTTCCGCAGCAGAAGGGTGGTGATCTGGCTGCCGGACGCGCCCGCAGA
CCTGTGGTGGATGTGGGGCCTGGTGAAGAGCACGGCTCTGGAGATCCACTCCAGGACCAAGGCC
CGGCTCCTCAGGCTGGTCAGATGTCCCCGTGAGGCCTTGTCCAGGCTGGCCCGTGTGCCCAGCG
AGCTGCCTGGCTCCTCCCTGGGCCTGTCTCCTGCTGCAGAGACCCCTGCCCTCCCCCTTCCTCC
TCCACAGCCGTTTCCTTGTCCTGGAGACCGGTGGGAGTGGCCAGCCTGGTTCACTGAGGGCCTT
GGGCAGGACCCCGACGTCAGCCTGGGCGCAGTGCCCCAGGGTGCCCCAGGGCCCCGCCCTTCGT
CAGCCCACAAGCCCTGGAACTTAGTCACCACCGGTTCCCTCCGCAGTCCGCCTGTCACCGTGGT
CGAGGACACGGCCCCCTCCAGCCCAGGGAAGCTCCTTCCATGGCCCTGTCCGCAGAGCTGTGGT
CCACCCTCAGGTCTGTAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005338658	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000019753.2

RefSeq Acc Id:

XP_005338658 ⟸ XM_005338601

- UniProtKB:

I3N5V7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDFLEEGSWSLSFAGAGFLGLYHVGVTQCLSQRAPRLLQGARRFYGSSSGALNALAIVCGKSTD
FCCSHLLDLVKHVEGLSLGIFHPAYAPIEHIKQQLQDKLPENSHILASQRLGISLTRWPDGHNF
IVTDFATRDELIQAVVCSLYFPFYCGTIPPEFRGQRYIDGALSNNLPFADCPSTITVSPFHGTV
DICPRSSSASLHELNAFNASFQISTKNFFLGFISLIPPKPEVVADNCRQGYLDALRFLEARGLT
KEPVLWTLVSRDPPAPPARTPDDGTSFNCHVPTVLVKDVPSLEQLSPELEAALRKAVRRDLGAW
ARFRRSGPGQVLSYLLLPCTLPFEYVYFRSRRVVIWLPDAPADLWWMWGLVKSTALEIHSRTKA
RLLRLVRCPREALSRLARVPSELPGSSLGLSPAAETPALPLPPPQPFPCPGDRWEWPAWFTEGL
GQDPDVSLGAVPQGAPGPRPSSAHKPWNLVTTGSLRSPPVTVVEDTAPSSPGKLLPWPCPQSCG
PPSGL

hide sequence

RefSeq Acc Id:

ENSSTOP00000019753 ⟸ ENSSTOT00000024869

Protein Domains

PNPLA

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000019885	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000024869.2	UniProtKB/TrEMBL
Gene3D-CATH	Cytosolic phospholipase A2 catalytic domain	UniProtKB/TrEMBL
InterPro	Acyl_Trfase/lysoPLipase	UniProtKB/TrEMBL
	PLPL	UniProtKB/TrEMBL
	PNPLA_dom	UniProtKB/TrEMBL
NCBI Gene	Pnpla5	ENTREZGENE
PANTHER	PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 5	UniProtKB/TrEMBL
	PTHR12406	UniProtKB/TrEMBL
Pfam	Patatin	UniProtKB/TrEMBL
PROSITE	PNPLA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52151	UniProtKB/TrEMBL
UniProt	I3N5V7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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