Abl1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) - Rat Genome Database

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Gene: Abl1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) Ictidomys tridecemlineatus
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Symbol: Abl1
Name: ABL proto-oncogene 1, non-receptor tyrosine kinase
RGD ID: 12552145
Description: ENCODES a protein that exhibits delta-catenin binding (ortholog); protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN actin filament polymerization (ortholog); activated T cell proliferation (ortholog); alpha-beta T cell differentiation (ortholog); PARTICIPATES IN p53 signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: c-abl oncogene 1, non-receptor tyrosine kinase; tyrosine-protein kinase ABL1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947197,921,710 - 198,051,040 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648717,690,206 - 17,819,619 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA)
actin filament polymerization  (ISO)
activated T cell proliferation  (IEA,ISO)
activation of protein kinase C activity  (IEA)
alpha-beta T cell differentiation  (IEA,ISO)
associative learning  (ISO)
B cell proliferation  (IEA,ISO)
B cell proliferation involved in immune response  (IEA,ISO)
B cell receptor signaling pathway  (IEA,ISO)
B-1 B cell homeostasis  (IEA,ISO)
Bergmann glial cell differentiation  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
cardiac muscle cell proliferation  (ISO)
cell communication  (IEA)
cell-cell adhesion  (IEA,ISO)
cellular response to DNA damage stimulus  (IEA)
cellular response to hydrogen peroxide  (IEA)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to oxidative stress  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular senescence  (IEA,ISO)
cerebellum morphogenesis  (IEA,ISO)
circulatory system development  (IEA,ISO)
DN4 thymocyte differentiation  (IEA,ISO)
DNA conformation change  (IEA)
endothelial cell migration  (IEA)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
establishment of protein localization  (ISO)
I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
integrin-mediated signaling pathway  (IEA)
learning or memory  (ISO)
microspike assembly  (IEA,ISO)
myoblast proliferation  (ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of cell-cell adhesion  (IEA,ISO)
negative regulation of cellular senescence  (IEA,ISO)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
negative regulation of long-term synaptic potentiation  (IEA)
negative regulation of mitotic cell cycle  (IEA,ISO)
negative regulation of phospholipase C activity  (IEA,ISO)
negative regulation of protein serine/threonine kinase activity  (IEA)
negative regulation of ubiquitin-protein transferase activity  (IEA,ISO)
neural tube closure  (IEA,ISO)
neuroepithelial cell differentiation  (IEA,ISO)
neuromuscular process controlling balance  (IEA,ISO)
neuron death  (IEA,ISO)
neuron differentiation  (IEA,ISO)
neuropilin signaling pathway  (IEA)
peptidyl-tyrosine autophosphorylation  (IEA)
peptidyl-tyrosine phosphorylation  (IEA,ISO)
phagocytosis  (IEA,ISO)
phosphorylation  (IEA)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
podocyte apoptotic process  (ISO)
positive regulation of actin cytoskeleton reorganization  (IEA)
positive regulation of actin filament binding  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of blood vessel branching  (IEA)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of dendrite development  (ISO)
positive regulation of endothelial cell migration  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of establishment of T cell polarity  (IEA)
positive regulation of extracellular matrix organization  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of focal adhesion assembly  (IEA)
positive regulation of hydrogen peroxide-mediated programmed cell death  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of microtubule binding  (IEA)
positive regulation of mitotic cell cycle  (IEA,ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (IEA,ISO)
positive regulation of osteoblast proliferation  (IEA,ISO)
positive regulation of oxidoreductase activity  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
positive regulation of stress fiber assembly  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
positive regulation of T cell migration  (IEA)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of vasoconstriction  (ISO)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)
post-embryonic development  (IEA,ISO)
protein autophosphorylation  (IEA,ISO)
protein localization to cytoplasmic microtubule plus-end  (IEA)
protein phosphorylation  (IEA)
regulation of actin cytoskeleton organization  (IEA,ISO)
regulation of axon extension  (IEA)
regulation of Cdc42 protein signal transduction  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of cellular senescence  (IEA,ISO)
regulation of extracellular matrix organization  (IEA,ISO)
regulation of microtubule polymerization  (IEA)
regulation of modification of synaptic structure  (IEA)
regulation of response to DNA damage stimulus  (IEA)
regulation of T cell differentiation  (IEA)
response to endoplasmic reticulum stress  (ISO)
response to epinephrine  (ISO)
response to oxidative stress  (IEA,ISO)
response to xenobiotic stimulus  (ISO)
signal transduction in response to DNA damage  (IEA)
signaling  (IEA)
spleen development  (IEA,ISO)
substrate adhesion-dependent cell spreading  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)
thymus development  (IEA,ISO)
transitional one stage B cell differentiation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Abl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947197,921,710 - 198,051,040 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648717,690,206 - 17,819,619 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389130,713,043 - 130,887,675 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9130,713,016 - 130,887,675 (+)EnsemblGRCh38hg38GRCh38
GRCh379133,588,430 - 133,763,062 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369132,579,089 - 132,752,883 (+)NCBINCBI36Build 36hg18NCBI36
Build 349130,619,260 - 130,792,614NCBI
Celera9104,127,800 - 104,301,349 (+)NCBICelera
Cytogenetic Map9q34.12NCBI
HuRef9103,075,969 - 103,249,725 (+)NCBIHuRef
CHM1_19133,738,310 - 133,911,675 (+)NCBICHM1_1
T2T-CHM13v2.09142,917,999 - 143,092,548 (+)NCBIT2T-CHM13v2.0
Abl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39231,578,256 - 31,697,105 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl231,578,388 - 31,694,239 (+)EnsemblGRCm39 Ensembl
GRCm38231,688,244 - 31,807,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl231,688,376 - 31,804,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv37231,544,076 - 31,659,747 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36231,581,991 - 31,626,236 (+)NCBIMGSCv36mm8
Celera231,389,208 - 31,506,940 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.86NCBI
Abl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2314,979,853 - 15,083,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl314,979,853 - 15,083,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,053,160 - 18,156,546 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0326,638,164 - 26,741,549 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0324,885,255 - 24,988,906 (+)NCBIRnor_WKY
Rnor_6.0310,041,820 - 10,145,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl310,041,826 - 10,144,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl39,410,661 - 9,448,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0315,401,182 - 15,504,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4310,804,594 - 10,907,162NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera39,728,420 - 9,830,777 (+)NCBICelera
Cytogenetic Map3p12NCBI
Abl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955513653,252 - 799,239 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955513652,048 - 799,182 (+)NCBIChiLan1.0ChiLan1.0
ABL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19130,482,852 - 130,652,941 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9130,484,333 - 130,652,941 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09101,834,189 - 102,005,811 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ABL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1953,118,462 - 53,262,092 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl953,119,641 - 53,261,307 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha952,318,603 - 52,461,396 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0954,019,016 - 54,162,127 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl954,019,025 - 54,161,522 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1952,796,621 - 52,939,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0953,117,155 - 53,260,443 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0953,210,098 - 53,353,656 (-)NCBIUU_Cfam_GSD_1.0
ABL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1270,761,668 - 270,906,708 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11270,761,641 - 270,906,708 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21304,684,385 - 304,829,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1127,258,932 - 7,435,658 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl127,256,648 - 7,312,734 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660798,028,989 - 8,209,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247604,878,556 - 5,031,491 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247604,878,811 - 5,032,719 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005321086   ⟹   XP_005321143
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947197,921,717 - 198,051,040 (+)NCBI
SpeTri2.0NW_00493648717,690,206 - 17,819,619 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005734165
RefSeq Status:
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947197,921,710 - 198,047,807 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005321143 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3288194 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005321143   ⟸   XM_005321086
- UniProtKB: I3NH11 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Protein kinase   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000026819 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000023658 ENTREZGENE
  ENSSTOP00000023658.2 UniProtKB/TrEMBL
  ENSSTOP00000028067.1 UniProtKB/TrEMBL
  ENSSTOP00000030838.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000019715.2 UniProtKB/TrEMBL
  ENSSTOT00000030186.1 UniProtKB/TrEMBL
  ENSSTOT00000041334.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro ABL1 UniProtKB/TrEMBL
  ABL_SH2 UniProtKB/TrEMBL
  F-actin-binding UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene Abl1 ENTREZGENE
PANTHER PTHR24418:SF162 UniProtKB/TrEMBL
Pfam F_actin_bind UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART FABD UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A287D3G7_ICTTR UniProtKB/TrEMBL
  A0A287DBB5_ICTTR UniProtKB/TrEMBL
  I3NH11 ENTREZGENE, UniProtKB/TrEMBL