Mthfs (methenyltetrahydrofolate synthetase) - Rat Genome Database

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Gene: Mthfs (methenyltetrahydrofolate synthetase) Ictidomys tridecemlineatus
Analyze
Symbol: Mthfs
Name: methenyltetrahydrofolate synthetase
RGD ID: 12550861
Description: ENCODES a protein that exhibits 5-formyltetrahydrofolate cyclo-ligase activity (ortholog); ATP binding (ortholog); folic acid binding (ortholog); INVOLVED IN folic acid catabolic process (ortholog); glutamate metabolic process (ortholog); tetrahydrofolate interconversion (ortholog); PARTICIPATES IN folate metabolic pathway; hereditary folate malabsorption pathway; methotrexate pharmacodynamics pathway; ASSOCIATED WITH Bloom syndrome (ortholog); cleft lip (ortholog); cleft palate (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase); 5-formyltetrahydrofolate cyclo-ligase; methenyltetrahydrofolate synthetase, transcript variant X1; methenyltetrahydrofolate synthetase, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640119,976,748 - 120,116,548 (-)NCBI
SpeTri2.0NW_00493647137,910,856 - 37,964,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Mthfs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640119,976,748 - 120,116,548 (-)NCBI
SpeTri2.0NW_00493647137,910,856 - 37,964,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1579,833,585 - 79,897,379 (-)EnsemblGRCh38hg38GRCh38
GRCh381579,843,547 - 79,897,285 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371580,135,889 - 80,189,627 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361577,924,373 - 77,976,425 (-)NCBINCBI36hg18NCBI36
Build 341577,924,374 - 77,976,395NCBI
Celera1557,073,628 - 57,125,676 (-)NCBI
Cytogenetic Map15q25.1NCBI
HuRef1556,894,007 - 56,947,724 (-)NCBIHuRef
CHM1_11580,252,880 - 80,306,583 (-)NCBICHM1_1
Mthfs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39989,093,243 - 89,122,278 (+)NCBIGRCm39mm39
GRCm39 Ensembl989,092,729 - 89,259,766 (+)Ensembl
GRCm38989,211,190 - 89,240,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl989,210,676 - 89,377,713 (+)EnsemblGRCm38mm10GRCm38
MGSCv37989,106,028 - 89,135,063 (+)NCBIGRCm37mm9NCBIm37
MGSCv36989,009,083 - 89,038,118 (+)NCBImm8
Celera988,839,126 - 88,843,217 (+)NCBICelera
Celera987,292,813 - 87,293,205 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
Mthfs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2889,729,498 - 89,801,998 (+)NCBI
Rnor_6.0 Ensembl896,564,877 - 96,614,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0896,564,877 - 96,614,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0896,071,796 - 96,121,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4894,058,605 - 94,108,277 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1894,078,059 - 94,127,729 (+)NCBI
Celera889,291,095 - 89,340,497 (+)NCBICelera
Cytogenetic Map8q31NCBI
Mthfs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955533720,255 - 756,893 (-)NCBIChiLan1.0ChiLan1.0
MTHFS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,480,935 - 57,514,836 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha360,139,116 - 60,173,501 (+)NCBI
ROS_Cfam_1.0357,913,790 - 57,950,014 (+)NCBI
UMICH_Zoey_3.1357,413,049 - 57,447,505 (+)NCBI
UNSW_CanFamBas_1.0357,620,059 - 57,654,466 (+)NCBI
UU_Cfam_GSD_1.0357,967,073 - 58,003,248 (+)NCBI
LOC102167410
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1748,717,518 - 48,873,492 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2754,276,934 - 54,313,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Mthfs
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624941856,196 - 894,057 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005316876   ⟹   XP_005316933
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640120,062,778 - 120,116,531 (-)NCBI
SpeTri2.0NW_00493647137,910,856 - 37,964,655 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013360044   ⟹   XP_013215498
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640120,062,778 - 120,116,138 (-)NCBI
SpeTri2.0NW_00493647137,910,856 - 37,964,148 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040275125   ⟹   XP_040131059
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640119,976,748 - 120,116,548 (-)NCBI
RefSeq Acc Id: XM_040275126   ⟹   XP_040131060
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640120,062,778 - 120,112,563 (-)NCBI
RefSeq Acc Id: XM_040275127   ⟹   XP_040131061
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640120,062,778 - 120,116,029 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005316933   ⟸   XM_005316876
- Peptide Label: isoform X1
- UniProtKB: I3MCZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013215498   ⟸   XM_013360044
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_040131059   ⟸   XM_040275125
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040131061   ⟸   XM_040275127
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040131060   ⟸   XM_040275126
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009124 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000008177 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000029142 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009121 UniProtKB/TrEMBL
  ENSSTOT00000039761 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10420 UniProtKB/TrEMBL
InterPro FTHF_cligase UniProtKB/TrEMBL
  FTHF_cligase-like_sf UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/TrEMBL
NCBI Gene Mthfs ENTREZGENE
PANTHER PTHR23407:SF1 UniProtKB/TrEMBL
Pfam 5-FTHF_cyc-lig UniProtKB/TrEMBL
PIRSF FTHF_cligase UniProtKB/TrEMBL
Superfamily-SCOP SSF100950 UniProtKB/TrEMBL
TIGRFAMs MTHFS_bact UniProtKB/TrEMBL
UniProt A0A287D6D3_ICTTR UniProtKB/TrEMBL
  I3MCZ0 ENTREZGENE, UniProtKB/TrEMBL