Ush1g (USH1 protein network component sans)

Gene: Ush1g (USH1 protein network component sans) Ictidomys tridecemlineatus

Analyze

Symbol:

Ush1g

Name:

USH1 protein network component sans

RGD ID:

12548960

Description:

ENCODES a protein that exhibits identical protein binding (inferred); spectrin binding (inferred); INVOLVED IN inner ear morphogenesis (ortholog); inner ear receptor cell differentiation (ortholog); inner ear receptor cell stereocilium organization (ortholog); PARTICIPATES IN auditory mechanotransduction pathway; retinitis pigmentosa pathway; ASSOCIATED WITH autosomal recessive nonsyndromic deafness (ortholog); Deafness (ortholog); genetic disease (ortholog); FOUND IN actin cytoskeleton (inferred); Cajal body (inferred); ciliary basal body (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Usher syndrome type-1G protein homolog

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	6,149,216 - 6,153,844 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	259,030 - 262,778 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	258,115 - 262,739 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive nonsyndromic deafness (ISO)

Deafness (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

Nonsyndromic Sensorineural Hearing Loss (ISO)

retinitis pigmentosa-deafness syndrome (ISO)

Usher syndrome (ISO)

Usher syndrome type 1 (ISO)

Usher syndrome type 1G (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

equilibrioception (IEA)

inner ear morphogenesis (IEA,ISO)

inner ear receptor cell differentiation (IEA,ISO)

inner ear receptor cell stereocilium organization (IEA,ISO)

photoreceptor cell maintenance (IEA)

regulation of clathrin-dependent endocytosis (IEA)

sensory perception of light stimulus (IEA)

sensory perception of sound (IEA,ISO)

Cellular Component

actin cytoskeleton (IEA)

Cajal body (IEA)

ciliary basal body (IEA)

ciliary base (IEA)

cytoplasm (IEA)

nuclear speck (IEA)

photoreceptor cell cilium (IEA)

photoreceptor connecting cilium (IEA)

photoreceptor inner segment (IEA)

Molecular Function

identical protein binding (IEA)

protein binding (ISO)

spectrin binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

auditory mechanotransduction pathway (ISO)

retinitis pigmentosa pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Ush1g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	6,149,216 - 6,153,844 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	259,030 - 262,778 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	258,115 - 262,739 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

USH1G
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	74,916,083 - 74,923,255 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	74,916,083 - 74,923,256 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	72,912,175 - 72,919,350 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	70,423,771 - 70,430,946 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	70,423,770 - 70,430,946	NCBI
Celera	17	69,505,403 - 69,512,577 (-)	NCBI		Celera
Cytogenetic Map	17	q25.1	NCBI
HuRef	17	68,322,527 - 68,329,702 (-)	NCBI		HuRef
CHM1_1	17	72,976,994 - 72,984,168 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	75,807,868 - 75,815,042 (-)	NCBI		T2T-CHM13v2.0

Ush1g
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	115,206,018 - 115,214,239 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	115,206,018 - 115,212,867 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	115,315,192 - 115,333,736 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	115,315,192 - 115,322,041 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	115,176,506 - 115,183,232 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	115,131,282 - 115,138,008 (-)	NCBI		MGSCv36	mm8
Celera	11	127,080,957 - 127,087,688 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	80.84	NCBI

Ush1g
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	101,055,923 - 101,062,753 (-)	NCBI		GRCr8
mRatBN7.2	10	100,559,721 - 100,563,590 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	100,557,629 - 100,563,590 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	105,619,880 - 105,623,749 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	105,082,939 - 105,086,808 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	100,480,712 - 100,484,581 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	103,866,566 - 103,873,416 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	103,869,377 - 103,873,246 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	104,422,722 - 104,428,735 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	105,395,184 - 105,399,053 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	105,406,916 - 105,414,392 (-)	NCBI
Celera	10	99,135,313 - 99,139,182 (-)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

Ush1g
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955553	1,788,401 - 1,796,441 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955553	1,788,443 - 1,795,139 (-)	NCBI	ChiLan1.0	ChiLan1.0

USH1G
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	90,953,217 - 90,960,563 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	95,776,198 - 95,783,565 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	68,861,622 - 68,868,822 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	74,417,766 - 74,424,794 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	74,419,769 - 74,424,794 (-)	Ensembl	panpan1.1		panPan2

USH1G
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	5,527,935 - 5,532,940 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	5,528,492 - 5,533,900 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	6,208,663 - 6,224,130 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	6,200,930 - 6,216,437 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	6,201,086 - 6,207,562 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	6,238,053 - 6,253,545 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	6,348,497 - 6,364,000 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	6,408,847 - 6,416,993 (+)	NCBI		UU_Cfam_GSD_1.0

USH1G
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	6,334,310 - 6,340,361 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	6,333,640 - 6,341,083 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	6,323,797 - 6,331,295 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

USH1G
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	46,757,704 - 46,764,113 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	46,758,042 - 46,761,682 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	17,544,260 - 17,550,554 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ush1g
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	4,755,688 - 4,761,180 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	4,747,260 - 4,761,223 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000021823 ⟹ ENSSTOP00000016083

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936594	259,030 - 262,778 (-)	Ensembl

RefSeq Acc Id:

XM_005332696 ⟹ XP_005332753

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	6,149,216 - 6,153,844 (+)	NCBI
SpeTri2.0	NW_004936594	258,115 - 262,739 (-)	NCBI

Sequence:

show sequence

ATGTCTTGGTAGCGGCTCTGGCGCTCCGCACCCTCCATCTGCGGCCGGCCGCGGGGGCTGGTGG
CCCTGGCCCCTGCCAGGCCCCCTCCCCTGACCCCATGCCTCAACCCTAACCCTTCTGCCCTCCC
CCGCGGGGGGCATTTCCCGGTGTCCCCTGCCCGCCCCGTCCAAGCCGGGCGCCATGAATGATCA
GTACCACCGGGCTGCCCGCGATGGCTACCTGGAGCTCCTCAAGGAGGCCACCCGGAAGGAGCTG
AATGCCCCCGACGAAGATGGCATGACTCCCACCCTCTGGGCTGCCTACCACGGAAACCTGGAGT
CGCTGCGCCTCATCGTGAGCCGCGGGGGTGACCCAGACAAGTGTGACATCTGGGGCAACACACC
CCTACATCTGGCAGCTTCCAATGGCCACCTGCACTGCCTGTCCTTCCTGGTGTCTTTTGGGGCC
AACATCTGGTGCCTGGACAACGACTACCACACGCCGCTGGACATGGCTGCCATGAAAGGTCACA
TGGAGTGCGTGCGCTATCTGGACTCCATCGCGGCCAAGCAAAGCAGCCTCAACCCCAAGCTGGT
GGGCAAGCTGAAGGACAAGGCCTTTCGTGAGGCGGAGCGGCGCATCCGGGAGTGCGCCAAGCTG
CAGCGCAAGCACCACGAGCGCATGGAGCGGCGCTACCGGCGAGAGCTGGCGGAGCGCTCCGACA
CGCTCAGCTTCTCCAGCCTCACGTCCAGCACCCTGAGCCGCCGGCTGCAGCACCTGACGCTGGG
CAGCCACCTGCCCTACTCGCAGGCCACACTGCACGGCACCGCTAAAGGCAAGACCAAGATCCAG
AAGAAGTTGGAGAGGCGCAAGCAGGGCGGCGAGGGCACCTTCAAGGTCTCGGAGGACGGCCGGA
AGAGCGTCCGCTCGCTCTCAGGCCTGCAACTAGGTAGCGACGTGATGTTCGTGCGCCAGGGCAC
CTACGCCAACCCCAAGGAGTGGGGCCGCGCCCCGCTCCGGGACATGTTCCTCTCGGATGAGGAC
AGCGTCTCCCGTGCCACGCTGGCGGCCGAGCCTGCCCACTCGGAGGTCAGCACCGACTCAGGTC
ACGATTCCCTGTTTACCCGCCCCGGCCTGGGCACCATGGTGTTCCGCAGAAACTACTTGAGCAG
CGGGCTGCACGGGCTGGGCCGCGAGGACGGGGGTCTGGATGAAGCAGGCACCCCGCGGGGTCGG
CTGCATAGCTCCCCCAGCCTGGACGATGACAGCCTGGGCAGTGCCAACAGCCTGCAGGATCGCA
GCTGCGGGGAGGAGCTGCCCTGGGACGAGCTGGACTTGGGCCTGGACGAGGACCTGGAGCCCGA
GACGAGCCCGCTGGAGACCTTCCTGGCCTCCCTGCACATGGAGGACTTTGCCGCCCTCCTGCGG
CAAGAGAAGATCGATCTGGAGGCGCTAATGCTAAAGCCATTACAGCTGCCCAAGGCTGCCACCA
CACTGGTCCTCCTGTAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005332753	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000016083.2
GenBank Protein	KAG3268541	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005332753 ⟸ XM_005332696

- UniProtKB:

I3MVD8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIW
GNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLN
PKLVGKLKDKAFREAERRIRECAKLQRKHHERMERRYRRELAERSDTLSFSSLTSSTLSRRLQH
LTLGSHLPYSQATLHGTAKGKTKIQKKLERRKQGGEGTFKVSEDGRKSVRSLSGLQLGSDVMFV
RQGTYANPKEWGRAPLRDMFLSDEDSVSRATLAAEPAHSEVSTDSGHDSLFTRPGLGTMVFRRN
YLSSGLHGLGREDGGLDEAGTPRGRLHSSPSLDDDSLGSANSLQDRSCGEELPWDELDLGLDED
LEPETSPLETFLASLHMEDFAALLRQEKIDLEALMLKPLQLPKAATTLVLL

hide sequence

RefSeq Acc Id:

ENSSTOP00000016083 ⟸ ENSSTOT00000021823

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000021597	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000021823.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.50	UniProtKB/TrEMBL
	1.25.40.20	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	SAM/pointed_sf	UniProtKB/TrEMBL
NCBI Gene	Ush1g	ENTREZGENE
PANTHER	ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED	UniProtKB/TrEMBL
	USHER SYNDROME TYPE-1G PROTEIN	UniProtKB/TrEMBL
Pfam	Ank_2	UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
SMART	ANK	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48403	UniProtKB/TrEMBL
UniProt	I3MVD8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations