Med17 (mediator complex subunit 17)

Gene: Med17 (mediator complex subunit 17) Ictidomys tridecemlineatus

Analyze

Symbol:

Med17

Name:

mediator complex subunit 17

RGD ID:

12548323

Description:

ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); protein ubiquitination (ortholog); regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH endometriosis (ortholog); genetic disease (ortholog); infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly (ortholog); FOUND IN core mediator complex (ortholog); ubiquitin ligase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

mediator of RNA polymerase II transcription subunit 17

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	78,871,484 - 78,893,390 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936674	997,259 - 1,019,953 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936674	998,036 - 1,019,937 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

endometriosis (ISO)

genetic disease (ISO)

infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly (ISO)

intellectual disability (ISO)

microcephaly (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of DNA-templated transcription (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of transcription initiation by RNA polymerase II (IEA)

protein ubiquitination (ISO)

regulation of transcription by RNA polymerase II (IEA,ISO)

somatic stem cell population maintenance (IEA,ISO)

Cellular Component

core mediator complex (IEA,ISO)

mediator complex (IEA)

nucleus (IEA)

transcription regulator complex (IEA)

ubiquitin ligase complex (ISO)

Molecular Function

nuclear receptor coactivator activity (IEA)

nuclear thyroid hormone receptor binding (IEA)

protein binding (ISO)

transcription coactivator activity (IEA)

transcription coregulator activity (IEA)

ubiquitin protein ligase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Med17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	78,871,484 - 78,893,390 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936674	997,259 - 1,019,953 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936674	998,036 - 1,019,937 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MED17
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	93,784,282 - 93,814,963 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	93,784,227 - 93,814,963 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	93,517,448 - 93,548,129 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	93,157,053 - 93,186,144 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	93,157,095 - 93,186,102	NCBI
Celera	11	90,808,857 - 90,837,937 (+)	NCBI		Celera
Cytogenetic Map	11	q21	NCBI
HuRef	11	89,594,312 - 89,623,193 (+)	NCBI		HuRef
CHM1_1	11	93,400,364 - 93,429,449 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	93,700,614 - 93,731,285 (+)	NCBI		T2T-CHM13v2.0

Med17
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	15,171,647 - 15,194,576 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	15,171,647 - 15,191,227 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	15,260,351 - 15,279,906 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	15,260,351 - 15,279,931 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	15,064,795 - 15,084,311 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	15,010,744 - 15,030,260 (-)	NCBI		MGSCv36	mm8
Celera	9	12,539,617 - 12,559,133 (-)	NCBI		Celera
Cytogenetic Map	9	A2	NCBI
cM Map	9	4.74	NCBI

Med17
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	20,382,995 - 20,401,993 (-)	NCBI		GRCr8
mRatBN7.2	8	12,101,594 - 12,120,592 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	12,101,594 - 12,120,592 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	16,083,107 - 16,102,171 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	14,380,857 - 14,399,921 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	12,364,550 - 12,383,548 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	13,522,257 - 13,835,302 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	13,819,563 - 13,835,168 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	13,756,806 - 13,774,832 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	8	13,465,155 - 13,466,922 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	12,062,713 - 12,081,709 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	12,064,449 - 12,083,299 (-)	NCBI
Celera	8	13,569,315 - 13,588,313 (-)	NCBI		Celera
Cytogenetic Map	8	q12	NCBI

Med17
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	755,975 - 777,480 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	755,975 - 779,934 (-)	NCBI	ChiLan1.0	ChiLan1.0

MED17
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	94,644,306 - 94,675,541 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	95,738,225 - 95,767,135 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	88,806,209 - 88,835,138 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	92,292,947 - 92,321,913 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	92,292,947 - 92,321,913 (+)	Ensembl	panpan1.1		panPan2

MED17
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	6,967,304 - 6,990,542 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	6,967,481 - 6,990,547 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	6,982,685 - 7,005,952 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	7,147,946 - 7,171,189 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	7,118,059 - 7,171,135 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	6,934,113 - 6,957,371 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	6,998,521 - 7,021,778 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	7,047,357 - 7,070,630 (-)	NCBI		UU_Cfam_GSD_1.0

MED17
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	26,192,201 - 26,228,612 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	26,192,206 - 26,214,177 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	29,825,463 - 29,847,759 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MED17
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	85,031,407 - 85,060,562 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	85,031,716 - 85,059,285 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	40,737,891 - 40,768,990 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Med17
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	38,427,918 - 38,451,198 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	38,427,854 - 38,450,625 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005337191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000008104 ⟹ ENSSTOP00000007256

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936674	997,259 - 1,019,953 (-)	Ensembl

RefSeq Acc Id:

XM_005337191 ⟹ XP_005337248

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	78,871,484 - 78,893,390 (+)	NCBI
SpeTri2.0	NW_004936674	998,036 - 1,019,937 (-)	NCBI

Sequence:

show sequence

CCGGAGCCTCACCGGTTTCGTTCCGTGGGACTTGTGGGGCGGAAACGTCGCAAAGCATTCTGGG
GACGGCGCTGTGCCGGAGCTGTTTTAGTTCTTGGGGTTCTGTTTGTCTTCGGGAGGGTTACGGA
TTTGCCGGCTTCCAGCCCACTGAAGCTGCCAGCATGTCAGGGGTGCGCGCTGTGCGGATCAGCA
TCGAGTCGGCCTGCGAGAAACAGGTCCAGGAGGTGGGCCTGGATGGCACTGAGACTTACTTGCA
GCCGCTGTCCATGTCGCAAAATCTGGCGCGTCTGGCCCAGAGGATCGACTTCAGCCAGGGTTCT
GGTTCCGAGGAGGAGGAGGCGGCGGGGGCCGAGGGCGATGCGCAGGATTGGGCGGGCGCGGGGT
CCAGTGCAGACCAGGACGACGAGGAAGGGTTGGTAAAATTTCAGCCTTCCCTTTGGCCTTGGGA
TTCAGTGAGGAACAATTTGAGAAGTGCCCTTACAGAGATGTGTGTTCTGTACGATGTTCTCAGT
ATTGTTAAAGATAAAAAATTTATGACTCTTGATCCTGTTTCTCAGGATGCACTTCCTCCAAAAC
AGAATCCTCAGACATTGCAACTGATATCTAAAAAGAAGTCACTTGCTGGAGCAGCACAAATACT
GTTGAAGGGAGCAGAAAGACTGACTAAATCAGTTACGGAAAATCAAGAAAACAAGCTACAAAGA
GACTTCAACTCTGAGCTCTTGAGATTAAGGCAACACTGGAAACTTAGAAAAGTTGGAGATAAAA
TTCTTGGGGATCTGAGCTACAGAAGTGCAGGGTCTCTTTTTCCCCATCATGGTACATTTGAAGT
AATAAAGAATACAGATATTGATCTGGATAAGAAGATACCTGAAGATTACTGTCCTCTTGATGTA
CAAATTCCTAGTGATTTAGAGGGGTCTGCATACATCAAGGTTTCCATTCAAAAACAGGCTCCAG
ACATAGGTGATCTTGGCACAGTTAACCTCTTCAAAAGACCTCTGCCCAAATCCAAACCAGGTTC
ACCACATTGGCAGACAAAATTAGAAGCAGCACAAAATGTTCTCTTATGTAAAGAAATTTTTGCA
CAACTCTCTCGGGAAGCTGTTCAGATCAAATCACAGATCCCACATATTGTGGTGAAAAACCAGA
TAATCTCTCAACCCTTTCCAAGCTTGCAGTTATCTATTTCTTTGTGCCATTCCTCAAATGATAA
GAAATCCCAAAAATCTGCTACTGAGAAGCAAAGTCCAGAGGACCACCTCTATGTCTTAGAGCAT
AATTTGCATCTACTGATTAGAGAGTTTCATAAACAGACCTTGAGTTCCATCATGATGCCTCACC
CAGCAAGTGCACCTTTTGGCCACAAGAGAATGAGACTTTCAGGTCCTCAAGCTTTTGATAAAAA
TGAAATTAACTCATTACAGTCCAGTGAAGGACTTCTGGAAAAAATAATTAAACAAGCAAAGCAT
ATTTTTCTGAGGAGTAGAACTGCTGCAACCATTGACAGCTTAGCAAGTCGCATTGAGGATCCTC
AGATACAGGCTCATTGGTCAAATATCAATGATGTTTATGAATCTAGTGTGAAAGTTTTAATCAC
ATCACAAGGTTATGAACAAATATGCAAGTCCATTCAGCTGCAACTGAATATTGGAGTTGAGCAG
ATTCGAGTTGTACACAGAGATGGAAGAGTAATTACACTGTCTCATCAGGAGCAGGAGCTACAGG
ATTTTCTTCTATCTCAGATGTCACAGCATCAGGTTCATGCAGTTCAACAGCTAGCCAAGGTTAT
GGGCTGGCAGGTACTCAGCTTCAGTAATCATGTGGGACTTGGGCCCATAGAGAGTATTGGCAAT
GCCTCTGCCATAACAGTGGCCTCCCCGAGTGGTGACTATGCTATTTCAGTTCGTAATGGACCTG
AAAGTGGCAGCAAGATTATGGTTCAGTTTCCTCGTAACCAATGTAAAGACATTCCAAAAAGTGA
TGTTTTACAAGATGGTAAATGGAGTCATCTTCGAGGGCCATTTAAAGAAGTTCAGTGGAATAAA
ATGGAAGGTCGAAACTTTGTTTATAAAATGGAGCTACTTATGTCTGCACTTAGCCCTTGTCTGC
TATGATTTTTTTTCCTGAAATTGACTTGAGATGTTTGCAAATTAATTATAAGCACAAAGAAGAG
AAATCTTCCACAGGAGTATTATTTAAAAATAATAATTAGTAAATGTTTTCCTAGCAATTTGAAA
TCTTTCACTTTATAAGTGATGTACTTTGAAATGCAGAAGTTTATGTACAGTTGTAGGTATATGG
GGAGATGTAAAATAATACATTTTTTTTTATACTGCAGTTAACCTGAAAGTGTTATTAATGGAGG
GGATTAAATTTGCTGTTTAAAATACCCAGTCTTTGATGTTAGCATCAAATAAAGTGTGTAGTTT
AAAAATCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005337248	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000007256.2
GenBank Protein	KAG3286363	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005337248 ⟸ XM_005337191

- UniProtKB:

I3MB13 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAE
GDAQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVKDKKFMTLD
PVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQ
HWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAY
IKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKS
QIPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKSATEKQSPEDHLYVLEHNLHLLIREFHK
QTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRTAATI
DSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVI
TLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSG
DYAISVRNGPESGSKIMVQFPRNQCKDIPKSDVLQDGKWSHLRGPFKEVQWNKMEGRNFVYKME
LLMSALSPCLL

hide sequence

RefSeq Acc Id:

ENSSTOP00000007256 ⟸ ENSSTOT00000008104

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000008098	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000008104.3	UniProtKB/TrEMBL
InterPro	Mediator_Med17	UniProtKB/TrEMBL
NCBI Gene	Med17	ENTREZGENE
PANTHER	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17	UniProtKB/TrEMBL
	PTHR13114	UniProtKB/TrEMBL
Pfam	Med17	UniProtKB/TrEMBL
UniProt	I3MB13	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations