Vcl (vinculin) - Rat Genome Database

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Gene: Vcl (vinculin) Ictidomys tridecemlineatus
Analyze
Symbol: Vcl
Name: vinculin
RGD ID: 12547372
Description: ENCODES a protein that exhibits actin binding (ortholog); molecular adaptor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN axon extension (ortholog); cell adhesion (ortholog); lamellipodium assembly (ortholog); PARTICIPATES IN E-cadherin signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); autism spectrum disorder (ortholog); cardiac arrest (ortholog); FOUND IN actin filament (ortholog); intercalated disc (ortholog); membrane raft (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: vinculin, transcript variant X1; vinculin, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721356,558,734 - 56,670,307 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365215,050,900 - 5,163,086 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365215,051,077 - 5,163,036 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Vcl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721356,558,734 - 56,670,307 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365215,050,900 - 5,163,086 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365215,051,077 - 5,163,036 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VCL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,998,116 - 74,121,363 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1073,995,193 - 74,121,363 (+)EnsemblGRCh38hg38GRCh38
GRCh371075,757,874 - 75,881,121 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361075,427,878 - 75,549,924 (+)NCBINCBI36Build 36hg18NCBI36
Build 341075,427,877 - 75,549,918NCBI
Celera1069,043,066 - 69,165,189 (+)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1069,753,196 - 69,875,221 (+)NCBIHuRef
CHM1_11076,039,663 - 76,161,889 (+)NCBICHM1_1
T2T-CHM13v2.01074,869,505 - 74,992,765 (+)NCBIT2T-CHM13v2.0
Vcl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,979,436 - 21,083,744 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,979,466 - 21,083,744 (+)EnsemblGRCm39 Ensembl
GRCm381420,929,383 - 21,033,676 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,929,398 - 21,033,676 (+)EnsemblGRCm38mm10GRCm38
MGSCv371421,748,655 - 21,852,895 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361419,717,985 - 19,822,225 (+)NCBIMGSCv36mm8
Celera1417,309,615 - 17,412,913 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.53NCBI
Vcl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8153,315,069 - 3,404,891 (-)NCBIGRCr8
mRatBN7.2153,265,776 - 3,355,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl153,265,815 - 3,355,606 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,275,988 - 3,365,714 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,662,476 - 4,752,199 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,274,793 - 3,364,523 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0153,455,211 - 3,544,738 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,455,211 - 3,544,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0153,433,521 - 3,522,441 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,478,214 - 3,576,911 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1153,480,194 - 3,654,123 (-)NCBI
Celera151,235,777 - 1,325,408 (+)NCBICelera
Cytogenetic Map15p16NCBI
Vcl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543717,813,007 - 17,920,253 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543717,812,998 - 17,920,253 (-)NCBIChiLan1.0ChiLan1.0
VCL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2886,149,471 - 86,269,838 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11086,154,475 - 86,275,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01070,521,259 - 70,641,917 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11073,191,384 - 73,311,301 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1073,191,375 - 73,311,296 (+)Ensemblpanpan1.1panPan2
VCL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1424,404,279 - 24,518,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl424,404,319 - 24,518,633 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha424,541,842 - 24,656,546 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0424,685,066 - 24,802,488 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl424,685,097 - 24,802,479 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1424,581,947 - 24,697,844 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0424,782,214 - 24,897,783 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0425,137,362 - 25,252,305 (+)NCBIUU_Cfam_GSD_1.0
VCL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,700,173 - 76,811,869 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11476,700,143 - 76,811,875 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,826,487 - 82,938,103 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q2.5-q2.9NCBI
VCL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1957,253,219 - 57,375,947 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl957,255,166 - 57,376,028 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604817,825,838 - 17,950,842 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vcl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247547,484,773 - 7,590,108 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247547,484,759 - 7,590,108 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000012872   ⟹   ENSSTOP00000011537
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365215,050,900 - 5,163,086 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000031279   ⟹   ENSSTOP00000028012
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365215,050,900 - 5,162,997 (-)Ensembl
RefSeq Acc Id: XM_005325893   ⟹   XP_005325950
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721356,558,734 - 56,670,307 (-)NCBI
SpeTri2.0NW_0049365215,051,077 - 5,163,036 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005325894   ⟹   XP_005325951
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721356,558,734 - 56,670,306 (-)NCBI
SpeTri2.0NW_0049365215,051,077 - 5,163,035 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005325950 (Get FASTA)   NCBI Sequence Viewer  
  XP_005325951 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000011537.3
  ENSSTOP00000028012.1
GenBank Protein KAG3264657 (Get FASTA)   NCBI Sequence Viewer  
  KAG3264658 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005325951   ⟸   XM_005325894
- Peptide Label: isoform X2
- UniProtKB: I3MJY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005325950   ⟸   XM_005325893
- Peptide Label: isoform X1
- UniProtKB: A0A287D3A9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000011537   ⟸   ENSSTOT00000012872
Ensembl Acc Id: ENSSTOP00000028012   ⟸   ENSSTOT00000031279


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012867 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012872.3 UniProtKB/TrEMBL
  ENSSTOT00000031279.1 UniProtKB/TrEMBL
Gene3D-CATH Alpha-catenin/vinculin-like UniProtKB/TrEMBL
  Vinculin, Vh2 four-helix bundle UniProtKB/TrEMBL
InterPro Alpha-catenin/vinculin-like_sf UniProtKB/TrEMBL
  Vinculin UniProtKB/TrEMBL
  Vinculin/catenin UniProtKB/TrEMBL
  Vinculin_CS UniProtKB/TrEMBL
NCBI Gene Vcl ENTREZGENE
PANTHER PTHR46180 UniProtKB/TrEMBL
Pfam Vinculin UniProtKB/TrEMBL
PRINTS VINCULIN UniProtKB/TrEMBL
PROSITE VINCULIN_1 UniProtKB/TrEMBL
  VINCULIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF47220 UniProtKB/TrEMBL
UniProt A0A287D3A9 ENTREZGENE, UniProtKB/TrEMBL
  I3MJY7 ENTREZGENE, UniProtKB/TrEMBL