Castor1 (cytosolic arginine sensor for mTORC1 subunit 1)

Gene: Castor1 (cytosolic arginine sensor for mTORC1 subunit 1) Ictidomys tridecemlineatus

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Symbol:

Castor1

Name:

cytosolic arginine sensor for mTORC1 subunit 1

RGD ID:

12546366

Description:

ENCODES a protein that exhibits arginine binding (inferred); identical protein binding (inferred); protein sequestering activity (inferred); INVOLVED IN cellular response to amino acid starvation (inferred); cellular response to L-arginine (inferred); negative regulation of TORC1 signaling (inferred); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN GATOR2 complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

GATS protein like 3; GATS-like protein 3; Gatsl3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	116,357,353 - 116,361,622 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936904	373,198 - 376,370 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936904	372,609 - 376,878 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to amino acid starvation (IEA)

cellular response to L-arginine (IEA)

negative regulation of TORC1 signaling (IEA)

positive regulation of TORC1 signaling (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

GATOR2 complex (IEA,ISO)

Molecular Function

arginine binding (IEA)

identical protein binding (IEA)

protein binding (ISO)

protein sequestering activity (IEA)

small molecule sensor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Castor1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	116,357,353 - 116,361,622 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936904	373,198 - 376,370 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936904	372,609 - 376,878 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CASTOR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	30,285,117 - 30,289,505 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	30,285,117 - 30,289,622 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	30,681,106 - 30,685,494 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	29,011,107 - 29,015,502 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	22	14,480,787 - 14,485,320 (-)	NCBI		Celera
Cytogenetic Map	22	q12.2	NCBI
HuRef	22	13,642,884 - 13,647,417 (-)	NCBI		HuRef
CHM1_1	22	30,640,242 - 30,644,751 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	30,748,432 - 30,752,844 (-)	NCBI		T2T-CHM13v2.0

Castor1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	4,167,401 - 4,172,409 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	4,168,225 - 4,172,409 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	4,218,166 - 4,222,409 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	4,218,225 - 4,222,409 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	4,118,254 - 4,122,412 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	4,118,254 - 4,122,412 (+)	NCBI		MGSCv36	mm8
Celera	11	4,715,195 - 4,719,353 (+)	NCBI		Celera
Cytogenetic Map	11	A1	NCBI
cM Map	11	2.94	NCBI

Castor1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	83,309,710 - 83,314,123 (+)	NCBI		GRCr8
mRatBN7.2	14	79,086,136 - 79,090,549 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	79,086,136 - 79,090,548 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	83,526,728 - 83,531,138 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	84,766,807 - 84,771,217 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	81,212,732 - 81,217,144 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	84,447,552 - 84,457,396 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	84,447,885 - 84,452,367 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	85,129,496 - 85,139,061 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	84,840,815 - 84,845,228 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	84,859,946 - 84,863,912 (+)	NCBI
Celera	14	77,997,130 - 78,001,543 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

Castor1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	4,531,325 - 4,535,217 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	4,530,842 - 4,535,358 (-)	NCBI	ChiLan1.0	ChiLan1.0

CASTOR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	40,252,281 - 40,256,971 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	42,950,890 - 42,955,556 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	11,321,259 - 11,325,787 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	29,123,198 - 29,127,736 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	29,123,198 - 29,127,736 (-)	Ensembl	panpan1.1		panPan2

CASTOR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	23,439,472 - 23,443,950 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	23,439,475 - 23,443,955 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	23,310,655 - 23,315,133 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	23,823,438 - 23,827,916 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	23,823,438 - 23,827,802 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	23,525,122 - 23,529,600 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	23,787,956 - 23,792,434 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	23,848,310 - 23,852,788 (-)	NCBI		UU_Cfam_GSD_1.0

CASTOR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	47,261,911 - 47,266,996 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	47,261,905 - 47,266,729 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	50,300,851 - 50,305,678 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CASTOR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	13,165,945 - 13,172,734 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	13,165,873 - 13,170,465 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	112,975,807 - 112,980,488 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Castor1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	6,600,335 - 6,604,890 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	6,592,962 - 6,604,811 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013365979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000010527 ⟹ ENSSTOP00000009446

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936904	373,198 - 376,370 (+)	Ensembl

RefSeq Acc Id:

XM_013365979 ⟹ XP_013221433

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	116,357,353 - 116,361,622 (-)	NCBI
SpeTri2.0	NW_004936904	372,609 - 376,878 (+)	NCBI

Sequence:

show sequence

GGGGGCTCTTCACTGTCTCTCCCGGCCAGGGTTGGAGGATTAGGATCGTCGCGAGGCGGGCGGG
AGCGGGAAGGCAGGCGCTCCCCCTCCGGCCGCCATCCGGCCTGGGCCTACCCTCCCGGGGACCG
CCGCCTATCCGGTCCCGGAGGCTGCATCCCAGGGCCAGTCAAGGCGCAAACAGCCTGGAGTGGG
CAATGCTTAACTCCGAATGGTGTGAAGTGGGGGCATTCCTACCTGGCCACTACGGAGAGCTTCT
TCTCGACGTCTCCCATCAGGTGTAAATTCTTCAGCCTGACGGAGACCCCCGAGGATTACACGCT
CATGGTGGACGAGGAGGGCTTTAAAGAGCTGCCCCCATCGGAATTTCTGCAAGTGGCTGAAGCC
ACCTGGCTGGTGATGAATGTATCGTCGCACAGTGGTGCAGCAGTGCAGGCTGCTGGGGTCACTA
AAATTGCTCGCTCAGTCATCACGCCACTGGCCGAGCACCATGTATCTGTGCTGATGCTATCCAC
TTACCAGACAGACTTCATCCTGGTGCGGGAGCAGGACCTGTCTGTGGTGATCCACACTCTGGCC
CAGGAGTTCGACATTTACCGTGAAGTGGGTGGGGAGCCTGTACCTGTTGCCAGGGATGATTCCA
GCAACGGCTTTCCTCGTGCCCAGCATGGGCCCAGCCCCACAGTGCATCCCATTCAGAGTCCACA
GAACCGCTTCTGTGTTCTCACACTGGACCCTGAGACACTGCCAGCCATCGCCACCACCCTCATT
GATGTCCTCTTCTACTCTCACAGTGCCCCCAAGGAAGTGGCCCCAGGCAGTCCTGAGCCCAGCT
CCATCCAATTCTTCGCCTTCTCCCTCATTGAGGGCTACATCTCTATCGTCATGGATGCTGAGAC
ACAAAAAAAATTCCCCAGTGACCTCCTGCTGACCAGTTCCTCAGGCGAGATGTGGAGGATGGTG
CGCATTGGTGGACAGCCCCTAGGCTTCGATGAATGTGGGATTGTGGCCCAGATTGCGGGTCCCC
TGGCTGCTGCTGACATCTCTGCATACTACATCAGCACTTTCAATTTTGACCATGCCCTGGTGCC
TGAGGATGGTATCAACAGTGTCATCGCAGTCCTCCAGCGAAGGCCAGAGAGCCTGGCCTCCTAA
GGCCTGTAGGGATCAGTGCAGAATCCCAGATATTCTGGGTTTCTAGAGACTTCTCTAAGCTATT
TCCTCAAGCTCTGGGATGATTTCCCCTGTTCCTGGCGGGGGAACCCTCATTCCACTCTCTGTAT
ATAAGCTGTGTGCTGGCACCGGCTCTCGTGGACACGTGTACACGCACAGGTGGAATGGGCAGGT
GCTAGCCCGACCGTGTGTCTACCCATGCGGGGAACATGGTGCTCTGGGGCTTAAGCCCCCAACC
CATCATTCCCTGTAGTGGCCTCAGCATTTGCACAGTCCCTGCCTGAGGCCTGAGCCATCCCCCT
CACCTCCCCTGAGGGCCAGCTGCCCCCACTGGGCAGGGTCCCATGTCTGGCTGGATCGCCTCCA
GTCAGGCAAAATCTTGACAGTGCCTCCCCCCTCCTGGGGCTTCCAAGAAAAGTGTTTTTTTTAC
TTCTGTTTCACTCTCTTTCTCTCTTTTTTAAAAAATCATCTGTTAATAAAAGACTTTATATTGA
CTAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013221433	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000009446.3
GenBank Protein	KAG3278387	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013221433 ⟸ XM_013365979

- Sequence:

show sequence

GGSSLSLPARVGGLGSSRGGREREGRRSPSGRHPAWAYPPGDRRLSGPGGCIPGPVKAQTAWSG
QCLTPNGVKWGHSYLATTESFFSTSPIRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEA
TWLVMNVSSHSGAAVQAAGVTKIARSVITPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLA
QEFDIYREVGGEPVPVARDDSSNGFPRAQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLI
DVLFYSHSAPKEVAPGSPEPSSIQFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGEMWRMV
RIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGINSVIAVLQRRPESLAS

hide sequence

RefSeq Acc Id:

ENSSTOP00000009446 ⟸ ENSSTOT00000010527

Protein Domains

CASTOR ACT CASTOR1 N-terminal Cytosolic arginine sensor for mTORC1 subunit 1/2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000010528	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000010527.3	UniProtKB/TrEMBL
Gene3D-CATH	VC0802-like	UniProtKB/TrEMBL
InterPro	ACT-like_dom_sf	UniProtKB/TrEMBL
	CASTOR1_ACT-like	UniProtKB/TrEMBL
	CASTOR1_N	UniProtKB/TrEMBL
	CASTOR_ACT_dom	UniProtKB/TrEMBL
	CASTOR_fam	UniProtKB/TrEMBL
NCBI Gene	Gatsl3	ENTREZGENE
PANTHER	CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE	UniProtKB/TrEMBL
	PTHR31131:SF3	UniProtKB/TrEMBL
Pfam	ACT_7	UniProtKB/TrEMBL
	CASTOR1_ACT-like	UniProtKB/TrEMBL
	Castor1_N	UniProtKB/TrEMBL
PRINTS	GATSLIKEFMLY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55021	UniProtKB/TrEMBL
UniProt	I3MFN3_ICTTR	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-02-24	Castor1	cytosolic arginine sensor for mTORC1 subunit 1	Gatsl3	GATS protein like 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations