Nkx1-2 (NK1 homeobox 2) - Rat Genome Database

Name: Nkx1-2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Nkx1-2 (NK1 homeobox 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Nkx1-2

Name:

NK1 homeobox 2

RGD ID:

12544360

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); RNA polymerase II cis-regulatory region sequence-specific DNA binding (inferred); INVOLVED IN cell differentiation (inferred); regulation of DNA-templated transcription (inferred); regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

NK1 transcription factor-related protein 2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NKX1-2 (NK1 homeobox 2)	NCBI	Ortholog
Mus musculus (house mouse):	Nkx1-2 (NK1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Nkx1-2 (NK1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nkx1-2 (NK1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NKX1-2 (NK1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NKX1-2 (NK1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NKX1-2 (NK1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NKX1-2 (NK1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nkx1-2 (NK1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	12,799,965 - 12,803,696 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	12,758,605 - 12,761,012 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936486	12,758,605 - 12,761,012 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Nkx1-2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	12,799,965 - 12,803,696 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	12,758,605 - 12,761,012 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936486	12,758,605 - 12,761,012 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NKX1-2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	124,445,243 - 124,450,035 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	124,445,243 - 124,450,035 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	126,133,812 - 126,138,604 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	126,125,988 - 126,128,534 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	10	119,908,245 - 119,910,797 (-)	NCBI		Celera
Cytogenetic Map	10	q26.13	NCBI
HuRef	10	119,820,731 - 119,823,283 (-)	NCBI		HuRef
CHM1_1	10	126,417,943 - 126,420,495 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	125,323,458 - 125,328,250 (-)	NCBI		T2T-CHM13v2.0

Nkx1-2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	132,197,968 - 132,201,366 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	132,196,607 - 132,201,366 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	132,596,239 - 132,599,637 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	132,594,878 - 132,599,637 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	139,787,922 - 139,791,320 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	132,434,582 - 132,437,980 (-)	NCBI		MGSCv36	mm8
Celera	7	132,401,209 - 132,404,607 (-)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	76.3	NCBI

Nkx1-2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	196,816,491 - 196,821,371 (-)	NCBI		GRCr8
mRatBN7.2	1	187,386,370 - 187,391,252 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	187,388,711 - 187,391,149 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	195,738,873 - 195,741,309 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	202,917,624 - 202,920,062 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	195,590,757 - 195,593,195 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	204,603,116 - 204,605,552 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	204,603,116 - 204,605,552 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	211,596,785 - 211,599,221 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	192,068,166 - 192,070,602 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	192,218,046 - 192,223,406 (-)	NCBI
Celera	1	185,133,266 - 185,135,702 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

Nkx1-2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955477	2,466,648 - 2,472,343 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955477	2,468,902 - 2,472,078 (-)	NCBI	ChiLan1.0	ChiLan1.0

NKX1-2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	136,290,937 - 136,295,826 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	136,296,288 - 136,301,177 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	121,003,744 - 121,008,956 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	125,271,422 - 125,276,267 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

NKX1-2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	33,806,298 - 33,811,258 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	33,806,292 - 33,811,458 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	33,871,006 - 33,873,739 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	34,365,282 - 34,368,009 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	34,365,367 - 34,368,443 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	33,921,976 - 33,924,704 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	33,914,368 - 33,917,093 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	34,165,425 - 34,168,166 (-)	NCBI		UU_Cfam_GSD_1.0

NKX1-2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	133,853,193 - 133,856,326 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	133,853,067 - 133,855,812 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	145,293,395 - 145,296,158 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NKX1-2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	117,107,266 - 117,112,632 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	117,109,479 - 117,112,002 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	78,424,820 - 78,431,531 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nkx1-2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	22,633,366 - 22,635,878 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	22,633,275 - 22,638,069 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005320753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000029304 ⟹ ENSSTOP00000023117

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936486	12,758,605 - 12,761,012 (-)	Ensembl

RefSeq Acc Id:

XM_005320753 ⟹ XP_005320810

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	12,799,965 - 12,803,696 (+)	NCBI
SpeTri2.0	NW_004936486	12,758,605 - 12,761,012 (-)	NCBI

Sequence:

show sequence

ATGCTGGCATGGCAGGACGGAGGGGCCAAGGCGGCTCCCTCCCACCACAAGATCTCCTTCTCGG
TCCTGGATATTTTGGACCCGCAGAAGTTCACCCGCACTGCGCTCCCCGCCGCGCGCCTCGCTCC
CCGGGAAGCCAAGAAAAGTTTGGCGGAGGTCGAAGCCAGGAAGGACACCAGGCCTGGGAACCGA
GTGCGACAGCAGGAGACCTTTGATACTACTGGCCAAGGCGCCGGTCCAGCGTCCCCCCTGGAGG
GTTCCGAGGCCGAAGAGCAAGAGGAGGACGCAGAGGACTCGGGACCTGAGCGCGCTCTGGTGGG
CCCCGCGCGCCCCCCCGAGGTCCGGGCCGCGGTGTTGGCGGGTGGAGAGAGCAAAGCGGAAGGC
TGTCCCAGCTCTCCAGGTTCCCCGAGGCCCCGGCGCCGGCGAGCTGAGCCCAGCTGCGCCAAGC
CGCGGCGAGCGCGCACCGCCTTCACCTACGAGCAGCTGGTGGCCTTGGAGAACAAGTTCCGGTC
CACGCGCTACCTGTCGGTGTGCGAGCGTCTGAACCTAGCGCTGTCGCTCAGCCTCACTGAGACA
CAGGTCAAAATCTGGTTCCAGAACCGCAGAACCAAGTGGAAGAAGCAGAACCCGGGCGCCGACG
GCGCGGCGCAAGGGGGCGGCGGTGCGCCTCAGCCTGGGACGCCGGGTGCGGCAGGGGGCACCGG
TACTGGAGGCAGTCCAGGACCCCCAGGCCCTGGCACTCTTTCCTTCCAGACTTTCCCCTCCTAC
TCCGCAGCCAGCGTCCTCTTCCCGGCCGCCACCGCTGCGGCCTCCTTCCCCTTGTCCGCCGCCA
GCGGGACCCCCTTCGCGCCCTTTCTGGGGCCCTCCTACTTGACCCCATTCTACGCCCCGCATCT
ATGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005320810	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000023117.1
GenBank Protein	KAG3263915	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005320810 ⟸ XM_005320753

- UniProtKB:

I3NFH0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLAWQDGGAKAAPSHHKISFSVLDILDPQKFTRTALPAARLAPREAKKSLAEVEARKDTRPGNR
VRQQETFDTTGQGAGPASPLEGSEAEEQEEDAEDSGPERALVGPARPPEVRAAVLAGGESKAEG
CPSSPGSPRPRRRRAEPSCAKPRRARTAFTYEQLVALENKFRSTRYLSVCERLNLALSLSLTET
QVKIWFQNRRTKWKKQNPGADGAAQGGGGAPQPGTPGAAGGTGTGGSPGPPGPGTLSFQTFPSY
SAASVLFPAATAAASFPLSAASGTPFAPFLGPSYLTPFYAPHL

hide sequence

RefSeq Acc Id:

ENSSTOP00000023117 ⟸ ENSSTOT00000029304

Protein Domains

Homeobox

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000021286	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000029304.1	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/TrEMBL
NCBI Gene	Nkx1-2	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN NKX	UniProtKB/TrEMBL
	NK1 TRANSCRIPTION FACTOR-RELATED PROTEIN 2	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
PRINTS	HOMEOBOX	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	I3NFH0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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