Abcc3 (ATP binding cassette subfamily C member 3) - Rat Genome Database

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Gene: Abcc3 (ATP binding cassette subfamily C member 3) Ictidomys tridecemlineatus
Analyze
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
RGD ID: 12543306
Description: ENCODES a protein that exhibits ABC-type bile acid transporter activity (ortholog); INVOLVED IN bile acid and bile salt transport (ortholog); canalicular bile acid transport (ortholog); monoatomic anion transmembrane transport (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); autism spectrum disorder (ortholog); bilirubin metabolic disorder (ortholog); FOUND IN basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-binding cassette sub-family C member 3; canalicular multispecific organic anion transporter 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,988,457 - 26,035,171 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,040,445 - 11,086,566 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,039,968 - 11,086,670 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Abcc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,988,457 - 26,035,171 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,040,445 - 11,086,566 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,039,968 - 11,086,670 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,634,881 - 50,692,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,634,777 - 50,692,253 (+)EnsemblGRCh38hg38GRCh38
GRCh371748,712,242 - 48,769,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,067,227 - 46,124,062 (+)NCBINCBI36Build 36hg18NCBI36
Build 341746,067,226 - 46,124,061NCBI
Celera1745,173,593 - 45,230,401 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1744,080,218 - 44,136,477 (+)NCBIHuRef
CHM1_11748,776,209 - 48,833,053 (+)NCBICHM1_1
T2T-CHM13v2.01751,502,046 - 51,559,449 (+)NCBIT2T-CHM13v2.0
Abcc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,234,121 - 94,283,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,234,121 - 94,283,823 (-)EnsemblGRCm39 Ensembl
GRCm381194,343,295 - 94,393,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,343,295 - 94,392,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,204,609 - 94,254,290 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,159,385 - 94,209,066 (-)NCBIMGSCv36mm8
Celera11103,962,067 - 104,011,589 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.9NCBI
Abcc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,793,571 - 79,839,528 (-)NCBIGRCr8
mRatBN7.21079,296,681 - 79,342,749 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,296,693 - 79,342,595 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1083,901,889 - 83,947,612 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,400,010 - 83,445,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,914,311 - 78,960,418 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,047,308 - 82,116,928 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,047,863 - 82,117,109 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01081,879,487 - 81,880,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01081,896,621 - 81,938,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,986,552 - 83,030,799 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1078,085,499 - 78,131,465 (-)NCBICelera
Cytogenetic Map10q26NCBI
Abcc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,087,570 - 11,130,482 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,087,246 - 11,130,108 (-)NCBIChiLan1.0ChiLan1.0
ABCC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,826,417 - 66,883,666 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,633,385 - 71,690,669 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1749,603,268 - 49,659,318 (+)Ensemblpanpan1.1panPan2
ABCC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,551,953 - 26,596,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,551,268 - 26,595,646 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,944,553 - 25,988,893 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0927,346,054 - 27,390,624 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl927,345,878 - 27,390,257 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1926,113,720 - 26,158,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,372,406 - 26,416,803 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,502,563 - 26,547,109 (+)NCBIUU_Cfam_GSD_1.0
ABCC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,920,821 - 26,979,602 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,920,764 - 26,978,389 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,060,930 - 27,117,540 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,646,316 - 42,703,124 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1642,646,812 - 42,702,852 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,362,436 - 13,419,564 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,516,224 - 6,557,892 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247956,516,384 - 6,558,332 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000024939   ⟹   ENSSTOP00000019756
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493649011,040,445 - 11,086,566 (-)Ensembl
RefSeq Acc Id: XM_005321631   ⟹   XP_005321688
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560225,988,461 - 26,035,171 (+)NCBI
SpeTri2.0NW_00493649011,039,968 - 11,086,670 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005726371
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560225,988,460 - 26,035,171 (+)NCBI
RefSeq Acc Id: XR_005726372
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560225,988,457 - 26,018,209 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005321688 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000019756.2
GenBank Protein KAG3269266 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005321688   ⟸   XM_005321631
- UniProtKB: I3N5W0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000019756   ⟸   ENSSTOT00000024939
Protein Domains
ABC transmembrane type-1   ABC transporter


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000027974 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000024939.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_C UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  Multidrug-R_assoc UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Abcc3 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/TrEMBL
  ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 3 UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF90123 UniProtKB/TrEMBL
UniProt I3N5W0 ENTREZGENE, UniProtKB/TrEMBL