Eng (endoglin) - Rat Genome Database
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Gene: Eng (endoglin) Ictidomys tridecemlineatus
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Symbol: Eng
Name: endoglin
RGD ID: 12542199
Description: ENCODES a protein that exhibits BMP binding (ortholog); coreceptor activity (ortholog); galactose binding (ortholog); INVOLVED IN angiogenesis (ortholog); artery morphogenesis (ortholog); atrial cardiac muscle tissue morphogenesis (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); arteriovenous malformation (ortholog); arteriovenous malformations of the brain (ortholog); FOUND IN cell surface (ortholog); endothelial microparticle (ortholog); external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648715,467,165 - 15,499,180 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
arteriovenous malformation  (ISO)
arteriovenous malformations of the brain  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
clear cell renal cell carcinoma  (ISO)
congenital disorder of glycosylation Iu  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
cystic fibrosis  (ISO)
developmental and epileptic encephalopathy 1  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Epistaxis  (ISO)
Fractures, Stress  (ISO)
Galloway-Mowat syndrome 1  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary hemorrhagic telangiectasia  (ISO)
Hereditary Hemorrhagic Telangiectasia, Type 1  (ISO)
Hereditary Hemorrhagic Telangiectasia, Type 2  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
intracranial aneurysm  (ISO)
juvenile polyposis syndrome  (ISO)
Kidney Reperfusion Injury  (ISO)
lymphoid leukemia  (ISO)
melanoma  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
pre-eclampsia  (ISO)
Pregnancy in Diabetics  (ISO)
Primary Pulmonary Hypertension, 1  (ISO)
prostate cancer  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Pulmonary Arterial Hypertension, Hereditary Hemorrhagic Telangiectasia-Related  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries, Experimental  (ISO)
renal fibrosis  (ISO)
Right Ventricular Hypertrophy  (ISO)
secondary hyperparathyroidism  (ISO)
systemic lupus erythematosus  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
artery morphogenesis  (ISO)
atrial cardiac muscle tissue morphogenesis  (ISO)
atrioventricular canal morphogenesis  (ISO)
bone development  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
cardiac atrium morphogenesis  (ISO)
cardiac jelly development  (ISO)
cardiac ventricle morphogenesis  (ISO)
cell chemotaxis  (ISO)
cell migration  (ISO)
cell migration involved in endocardial cushion formation  (ISO)
cell motility  (ISO)
cellular response to mechanical stimulus  (ISO)
central nervous system vasculogenesis  (ISO)
detection of hypoxia  (ISO)
dorsal aorta morphogenesis  (ISO)
endocardial cushion morphogenesis  (ISO)
endocardial cushion to mesenchymal transition  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
extracellular matrix constituent secretion  (ISO)
extracellular matrix disassembly  (ISO)
heart development  (ISO)
heart looping  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
negative regulation of protein autophosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
outflow tract septum morphogenesis  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of systemic arterial blood pressure  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (ISO)
regulation of cardiac muscle cell apoptotic process  (ISO)
regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
regulation of cell proliferation involved in heart morphogenesis  (ISO)
regulation of transcription, DNA-templated  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
response to corticosteroid  (ISO)
response to drug  (ISO)
response to hypoxia  (ISO)
response to transforming growth factor beta  (ISO)
smooth muscle tissue development  (ISO)
sprouting angiogenesis  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
vascular associated smooth muscle cell development  (ISO)
vasculogenesis  (ISO)
venous blood vessel morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Eng
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648715,467,165 - 15,499,180 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9127,815,013 - 127,854,658 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl9127,815,012 - 127,854,756 (-)EnsemblGRCh38hg38GRCh38
GRCh389127,815,012 - 127,854,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379130,577,291 - 130,617,052 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,617,115 - 129,656,805 (-)NCBINCBI36hg18NCBI36
Build 349127,656,849 - 127,696,538NCBI
Celera9101,228,133 - 101,267,888 (-)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9100,194,111 - 100,234,515 (-)NCBIHuRef
CHM1_19130,728,823 - 130,768,983 (-)NCBICHM1_1
Eng
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,536,607 - 32,572,681 (+)NCBIGRCm39mm39
GRCm39 Ensembl232,536,607 - 32,572,681 (+)Ensembl
GRCm38232,646,595 - 32,682,669 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,646,595 - 32,682,669 (+)EnsemblGRCm38mm10GRCm38
MGSCv37232,502,115 - 32,538,189 (+)NCBIGRCm37mm9NCBIm37
MGSCv36232,468,604 - 32,504,127 (+)NCBImm8
Celera232,353,177 - 32,389,276 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Eng
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2315,934,566 - 15,972,618 (+)NCBI
Rnor_6.0 Ensembl311,679,530 - 11,717,485 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0311,679,530 - 11,717,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0317,021,673 - 17,058,548 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera310,675,660 - 10,713,537 (+)NCBICelera
Cytogenetic Map3p11NCBI
Eng
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419818,932 - 852,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955419818,797 - 853,319 (+)NCBIChiLan1.0ChiLan1.0
ENG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19127,605,608 - 127,644,641 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,605,608 - 127,644,641 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0998,934,080 - 98,973,862 (-)NCBIMhudiblu_PPA_v0panPan3
ENG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl955,558,305 - 55,589,064 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1955,558,246 - 55,590,081 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ENG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,306,120 - 268,343,827 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,309,379 - 268,343,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,232,063 - 302,266,139 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENG
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,274,705 - 10,315,715 (+)NCBI
ChlSab1.1 Ensembl1210,275,064 - 10,315,040 (+)Ensembl
Eng
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247607,703,979 - 7,735,636 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005321001   ⟹   XP_005321058
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493648715,467,165 - 15,499,180 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005321058 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005321058   ⟸   XM_005321001
- Sequence:
Protein Domains
ZP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008315 UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000007460 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008322 UniProtKB/TrEMBL
InterPro ZP_dom UniProtKB/TrEMBL
NCBI Gene Eng ENTREZGENE
Pfam Zona_pellucida UniProtKB/TrEMBL
UniProt I3MBF2_ICTTR UniProtKB/TrEMBL