Nrp1 (neuropilin 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Nrp1 (neuropilin 1) Ictidomys tridecemlineatus
Analyze
Symbol: Nrp1
Name: neuropilin 1
RGD ID: 12538049
Description: ENCODES a protein that exhibits growth factor binding (ortholog); GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN actin cytoskeleton reorganization (ortholog); angiogenesis (ortholog); angiogenesis involved in coronary vascular morphogenesis (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ASSOCIATED WITH endometriosis (ortholog); Experimental Diabetes Mellitus (ortholog); hepatocellular carcinoma (ortholog); FOUND IN axon (ortholog); cell surface (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: neuropilin 1, transcript variant X1; neuropilin 1, transcript variant X2; neuropilin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934412,194,941 - 12,335,217 (-)NCBI
SpeTri2.0NW_0049365741,694,433 - 1,834,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (ISO)
angiogenesis  (ISO)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
artery morphogenesis  (ISO)
axon extension involved in axon guidance  (ISO)
axon guidance  (ISO)
axonal fasciculation  (ISO)
axonogenesis involved in innervation  (ISO)
basal dendrite arborization  (ISO)
basal dendrite development  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
branchiomotor neuron axon guidance  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cell migration  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
commissural neuron axon guidance  (ISO)
coronary artery morphogenesis  (ISO)
dendrite development  (ISO)
dichotomous subdivision of terminal units involved in salivary gland branching  (ISO)
dorsal root ganglion morphogenesis  (ISO)
endothelial cell chemotaxis  (ISO)
endothelial cell migration  (ISO)
facial nerve structural organization  (ISO)
facioacoustic ganglion development  (ISO)
gonadotrophin-releasing hormone neuronal migration to the hypothalamus  (ISO)
heart development  (ISO)
hepatocyte growth factor receptor signaling pathway  (ISO)
integrin-mediated signaling pathway  (ISO)
motor neuron axon guidance  (ISO)
motor neuron migration  (ISO)
negative regulation of axon extension  (ISO)
negative regulation of axon extension involved in axon guidance  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO)
nerve development  (ISO)
neural crest cell migration involved in autonomic nervous system development  (ISO)
neuron development  (ISO)
neuron migration  (ISO)
neuropilin signaling pathway  (ISO)
otic placode development  (ISO)
outflow tract septum morphogenesis  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive chemotaxis  (ISO)
positive regulation of actin cytoskeleton reorganization  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of axon extension involved in axon guidance  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of retinal ganglion cell axon guidance  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
postsynapse organization  (ISO)
protein localization to early endosome  (ISO)
regulation of axon extension involved in axon guidance  (ISO)
regulation of Cdc42 protein signal transduction  (ISO)
regulation of retinal ganglion cell axon guidance  (ISO)
renal artery morphogenesis  (ISO)
response to wounding  (ISO)
retina vasculature morphogenesis in camera-type eye  (ISO)
retinal ganglion cell axon guidance  (ISO)
semaphorin-plexin signaling pathway  (ISO)
semaphorin-plexin signaling pathway involved in axon guidance  (ISO)
semaphorin-plexin signaling pathway involved in neuron projection guidance  (ISO)
sensory neuron axon guidance  (ISO)
sprouting angiogenesis  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
substrate-dependent cell migration, cell extension  (ISO)
sympathetic ganglion development  (ISO)
sympathetic nervous system development  (ISO)
sympathetic neuron projection extension  (ISO)
sympathetic neuron projection guidance  (ISO)
toxin transport  (ISO)
trigeminal ganglion development  (ISO)
trigeminal nerve morphogenesis  (ISO)
trigeminal nerve structural organization  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)
VEGF-activated neuropilin signaling pathway  (ISO)
VEGF-activated neuropilin signaling pathway involved in axon guidance  (ISO)
ventral trunk neural crest cell migration  (ISO)
vestibulocochlear nerve structural organization  (ISO)
viral entry into host cell  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Nrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934412,194,941 - 12,335,217 (-)NCBI
SpeTri2.0NW_0049365741,694,433 - 1,834,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1033,177,492 - 33,336,262 (-)EnsemblGRCh38hg38GRCh38
GRCh381033,177,493 - 33,334,667 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371033,466,421 - 33,623,595 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361033,506,432 - 33,663,839 (-)NCBINCBI36hg18NCBI36
Build 341033,506,432 - 33,663,476NCBI
Celera1033,231,763 - 33,389,179 (-)NCBI
Cytogenetic Map10p11.22NCBI
HuRef1033,186,444 - 33,343,500 (-)NCBIHuRef
CHM1_11033,468,091 - 33,625,451 (-)NCBICHM1_1
Nrp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398129,085,072 - 129,231,957 (+)NCBIGRCm39mm39
GRCm39 Ensembl8129,085,085 - 129,229,844 (+)Ensembl
GRCm388128,358,591 - 128,505,476 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8128,358,604 - 128,503,363 (+)EnsemblGRCm38mm10GRCm38
MGSCv378130,882,973 - 131,029,376 (+)NCBIGRCm37mm9NCBIm37
MGSCv368131,228,923 - 131,389,437 (+)NCBImm8
Celera8132,685,332 - 132,831,714 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map875.78NCBI
Nrp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21956,359,455 - 56,514,628 (+)NCBI
Rnor_6.0 Ensembl1961,332,351 - 61,485,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01961,332,351 - 61,486,166 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01971,984,687 - 72,138,092 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41958,332,004 - 58,487,686 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11958,337,063 - 58,492,741 (+)NCBI
Celera1955,693,756 - 55,846,090 (+)NCBICelera
Cytogenetic Map19q12NCBI
Nrp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554624,101,999 - 4,241,012 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554624,101,997 - 4,241,012 (+)NCBIChiLan1.0ChiLan1.0
NRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11033,883,162 - 34,039,645 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1033,883,173 - 34,039,648 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01033,298,918 - 33,456,466 (-)NCBIMhudiblu_PPA_v0panPan3
NRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.123,416,062 - 3,553,929 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl23,413,821 - 3,552,483 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha23,515,185 - 3,653,323 (+)NCBI
ROS_Cfam_1.023,710,166 - 3,848,420 (+)NCBI
UMICH_Zoey_3.123,489,029 - 3,627,209 (+)NCBI
UNSW_CanFamBas_1.023,524,020 - 3,661,782 (+)NCBI
UU_Cfam_GSD_1.023,642,794 - 3,780,784 (+)NCBI
NRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1056,280,363 - 56,430,777 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11056,280,673 - 56,430,832 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21061,651,758 - 61,802,358 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NRP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1932,474,787 - 32,632,746 (-)NCBI
ChlSab1.1 Ensembl932,474,309 - 32,633,101 (-)Ensembl
Vero_WHO_p1.0NW_02366605641,535,637 - 41,695,579 (-)NCBI
Nrp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248058,438,485 - 8,574,845 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005330824   ⟹   XP_005330881
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934412,194,941 - 12,335,217 (-)NCBI
SpeTri2.0NW_0049365741,694,433 - 1,834,720 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005330825   ⟹   XP_005330882
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934412,194,941 - 12,335,217 (-)NCBI
SpeTri2.0NW_0049365741,694,433 - 1,834,711 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005330881 (Get FASTA)   NCBI Sequence Viewer  
  XP_005330882 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3257479 (Get FASTA)   NCBI Sequence Viewer  
  KAG3257480 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005330881   ⟸   XM_005330824
- Peptide Label: isoform X1
- UniProtKB: I3ML37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005330882   ⟸   XM_005330825
- Peptide Label: isoform X2
- Sequence:
Protein Domains
CUB   F5/8 type C   MAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013476 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000012083 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013485 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.260 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  CUB_dom UniProtKB/TrEMBL
  FA58C UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  MAM_dom UniProtKB/TrEMBL
  Neuropilin UniProtKB/TrEMBL
  Neuropilin_C UniProtKB/TrEMBL
  NRP1 UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
NCBI Gene Nrp1 ENTREZGENE
PANTHER PTHR46806:SF4 UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  DUF3481 UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
PIRSF Neuropilin UniProtKB/TrEMBL
PRINTS MAMDOMAIN UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  FA58C_1 UniProtKB/TrEMBL
  FA58C_2 UniProtKB/TrEMBL
  FA58C_3 UniProtKB/TrEMBL
  MAM_1 UniProtKB/TrEMBL
  MAM_2 UniProtKB/TrEMBL
SMART CUB UniProtKB/TrEMBL
  FA58C UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/TrEMBL
  SSF49854 UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt I3ML37 ENTREZGENE, UniProtKB/TrEMBL