Ptgr3 (prostaglandin reductase 3) - Rat Genome Database

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Gene: Ptgr3 (prostaglandin reductase 3) Ictidomys tridecemlineatus
Analyze
Symbol: Ptgr3
Name: prostaglandin reductase 3 (Ensembl:zinc binding alcohol dehydrogenase domain containing 2)
RGD ID: 12535621
Description: ENCODES a protein that exhibits 13-prostaglandin reductase activity (inferred); oxidoreductase activity (inferred); zinc ion binding (inferred); INVOLVED IN negative regulation of fat cell differentiation (inferred); prostaglandin metabolic process (inferred); ASSOCIATED WITH chromosome 18q deletion syndrome (ortholog); genetic disease (ortholog); intestinal volvulus (ortholog); FOUND IN mitochondrion (inferred); peroxisome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Zadh2; zinc binding alcohol dehydrogenase domain containing 2; zinc-binding alcohol dehydrogenase domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494418,106,915 - 18,116,203 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366163,428,045 - 3,439,945 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366163,428,045 - 3,438,092 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ptgr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494418,106,915 - 18,116,203 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366163,428,045 - 3,439,945 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366163,428,045 - 3,438,092 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381875,195,108 - 75,209,139 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1875,195,113 - 75,209,139 (-)EnsemblGRCh38hg38GRCh38
GRCh371872,907,063 - 72,921,094 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361871,039,464 - 71,050,105 (-)NCBINCBI36Build 36hg18NCBI36
Build 341871,039,470 - 71,050,105NCBI
Celera1869,727,946 - 69,739,950 (-)NCBICelera
Cytogenetic Map18q22.3NCBI
HuRef1869,594,140 - 69,606,087 (-)NCBIHuRef
CHM1_11872,903,933 - 72,915,937 (-)NCBICHM1_1
T2T-CHM13v2.01875,424,502 - 75,438,532 (-)NCBIT2T-CHM13v2.0
Ptgr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391884,106,250 - 84,115,579 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1884,106,188 - 84,115,653 (+)EnsemblGRCm39 Ensembl
GRCm381884,088,126 - 84,097,528 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1884,088,063 - 84,097,528 (+)EnsemblGRCm38mm10GRCm38
MGSCv371884,257,550 - 84,266,906 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361884,222,351 - 84,231,707 (+)NCBIMGSCv36mm8
Celera1885,156,040 - 85,165,162 (+)NCBICelera
Cytogenetic Map18E4NCBI
cM Map1857.53NCBI
Ptgr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81879,729,282 - 79,738,632 (+)NCBIGRCr8
mRatBN7.21877,454,435 - 77,463,785 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1877,454,435 - 77,463,785 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1879,561,463 - 79,570,827 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01880,233,544 - 80,242,902 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01878,069,184 - 78,078,548 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01880,939,875 - 80,949,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1880,939,875 - 80,949,226 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01879,987,672 - 79,997,023 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41880,613,957 - 80,623,307 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11880,687,407 - 80,695,298 (+)NCBI
Celera1876,077,940 - 76,087,290 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
Ptgr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540258,632,530 - 58,642,007 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540258,634,433 - 58,642,498 (-)NCBIChiLan1.0ChiLan1.0
PTGR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21792,740,841 - 92,752,265 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11878,433,095 - 78,444,899 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01868,584,392 - 68,596,230 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11871,859,470 - 71,870,915 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1871,859,470 - 71,870,919 (-)Ensemblpanpan1.1panPan2
PTGR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114,303,933 - 4,311,675 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14,303,922 - 4,311,455 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha15,311,503 - 5,319,250 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014,115,309 - 4,123,058 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14,115,391 - 4,123,070 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114,153,583 - 4,161,328 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014,106,751 - 4,114,493 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014,277,984 - 4,285,626 (+)NCBIUU_Cfam_GSD_1.0
PTGR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1148,987,518 - 148,997,954 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11148,987,197 - 148,995,138 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21164,776,841 - 164,784,056 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTGR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1184,702,671 - 4,712,792 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl184,702,617 - 4,714,272 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606021,158,258 - 21,170,082 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248065,465,370 - 5,476,260 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248065,465,755 - 5,476,891 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005334378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000030009   ⟹   ENSSTOP00000022752
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366163,428,045 - 3,439,945 (+)Ensembl
RefSeq Acc Id: XM_005334378   ⟹   XP_005334435
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494418,106,915 - 18,116,203 (+)NCBI
SpeTri2.0NW_0049366163,428,045 - 3,438,092 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005334435 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000022752.1
Reference Protein Sequences
RefSeq Acc Id: XP_005334435   ⟸   XM_005334378
- UniProtKB: I3NEF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000022752   ⟸   ENSSTOT00000030009
Protein Domains
Enoyl reductase (ER)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000024479 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000030009.2 UniProtKB/TrEMBL
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro ADH_C UniProtKB/TrEMBL
  ADH_N UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  PKS_ER UniProtKB/TrEMBL
  Quin_OxRdtase/zeta-crystal_CS UniProtKB/TrEMBL
NCBI Gene Zadh2 ENTREZGENE
PANTHER PROSTAGLANDIN REDUCTASE 3 UniProtKB/TrEMBL
  SHORT-CHAIN DEHYDROGENASE/REDUCTASE UniProtKB/TrEMBL
Pfam ADH_N UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/TrEMBL
PROSITE QOR_ZETA_CRYSTAL UniProtKB/TrEMBL
SMART PKS_ER UniProtKB/TrEMBL
Superfamily-SCOP SSF50129 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt I3NEF5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-02-08 Ptgr3  prostaglandin reductase 3  Zadh2  zinc binding alcohol dehydrogenase domain containing 2  Symbol and/or name change 5135510 APPROVED