Psma3 (proteasome 20S subunit alpha 3)

Gene: Psma3 (proteasome 20S subunit alpha 3) Ictidomys tridecemlineatus

Analyze

Symbol:

Psma3

Name:

proteasome 20S subunit alpha 3

RGD ID:

12525295

Description:

ENCODES a protein that exhibits ubiquitin protein ligase binding (inferred); INVOLVED IN proteasomal protein catabolic process (inferred); proteolysis involved in protein catabolic process (inferred); ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); Joubert syndrome 23 (ortholog); proteasome-associated autoinflammatory syndrome 1 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

proteasome subunit alpha 3; proteasome subunit alpha 3, transcript variant X1; proteasome subunit alpha 3, transcript variant X2; proteasome subunit alpha type-3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	71,519,504 - 71,541,053 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936495	2,650,629 - 2,673,435 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936495	2,650,668 - 2,672,192 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Joubert syndrome 23 (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteasomal protein catabolic process (IEA)

proteolysis involved in protein catabolic process (IEA)

ubiquitin-dependent protein catabolic process (IEA)

Cellular Component

cytoplasm (IEA,ISO)

nucleus (IEA,ISO)

proteasome complex (IEA)

proteasome core complex (IEA)

proteasome core complex, alpha-subunit complex (IEA)

synapse (IEA)

Molecular Function

protein binding (ISO)

ubiquitin protein ligase binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Psma3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	71,519,504 - 71,541,053 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936495	2,650,629 - 2,673,435 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936495	2,650,668 - 2,672,192 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PSMA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	58,244,843 - 58,272,004 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	58,244,843 - 58,272,012 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	58,711,561 - 58,738,722 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	57,781,346 - 57,808,479 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	57,781,345 - 57,808,479	NCBI
Celera	14	38,761,540 - 38,788,685 (+)	NCBI		Celera
Cytogenetic Map	14	q23.1	NCBI
HuRef	14	38,877,058 - 38,904,216 (+)	NCBI		HuRef
CHM1_1	14	58,650,049 - 58,677,295 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	52,451,770 - 52,478,987 (+)	NCBI		T2T-CHM13v2.0

Psma3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	71,016,082 - 71,042,651 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	71,021,395 - 71,043,121 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	70,969,283 - 70,995,877 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	70,974,621 - 70,996,347 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	72,075,610 - 72,095,924 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	71,893,298 - 71,913,526 (+)	NCBI		MGSCv36	mm8
Celera	12	72,078,082 - 72,098,500 (+)	NCBI		Celera
Cytogenetic Map	12	C2	NCBI
cM Map	12	29.39	NCBI

Psma3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	95,219,714 - 95,239,745 (+)	NCBI		GRCr8
mRatBN7.2	6	89,483,741 - 89,503,775 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	89,483,727 - 89,504,965 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	89,868,034 - 89,888,332 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	90,167,503 - 90,187,803 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	89,606,993 - 89,627,292 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	93,423,029 - 93,444,223 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	93,423,002 - 93,444,240 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	102,868,534 - 102,898,751 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	93,092,191 - 93,112,167 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	93,095,646 - 93,115,622 (+)	NCBI
Celera	6	87,965,854 - 87,985,832 (+)	NCBI		Celera
Cytogenetic Map	6	q24	NCBI

Psma3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955466	11,979,482 - 11,997,952 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955466	11,979,482 - 11,997,952 (+)	NCBI	ChiLan1.0	ChiLan1.0

PSMA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	59,364,546 - 59,394,007 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	58,583,210 - 58,610,522 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	38,836,869 - 38,864,152 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	57,105,891 - 57,133,181 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	57,105,891 - 57,133,181 (+)	Ensembl	panpan1.1		panPan2

PSMA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	33,616,735 - 33,642,434 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	33,616,480 - 33,642,404 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	33,378,219 - 33,403,729 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	33,858,343 - 33,884,028 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	33,858,385 - 33,884,037 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	33,471,278 - 33,496,743 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	33,538,435 - 33,564,256 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	33,913,572 - 33,939,074 (+)	NCBI		UU_Cfam_GSD_1.0

PSMA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	187,343,507 - 187,372,193 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	187,342,231 - 187,371,149 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	208,246,764 - 208,274,223 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PSMA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	35,438,084 - 35,465,320 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	35,437,308 - 35,465,203 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	23,674,689 - 23,701,992 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Psma3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624884	3,324,418 - 3,346,128 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624884	3,324,390 - 3,346,128 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005322743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021724757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040275263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000013540 ⟹ ENSSTOP00000012133

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936495	2,650,629 - 2,673,435 (+)	Ensembl

RefSeq Acc Id:

XM_005322743 ⟹ XP_005322800

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	71,519,504 - 71,541,053 (-)	NCBI
SpeTri2.0	NW_004936495	2,650,668 - 2,672,192 (+)	NCBI

Sequence:

show sequence

GTTGAAATTGCAGCCAATGGGAGGGCTTGTTACTAGTCTGCGCGGTGCGGAGCTTGTAGGGAAA
GTGCTTTGGGCCTGGAACCTCTACACATCCCGGTGGTTTTAGCACGATGAGCTCCATCGGCACC
GGGTATGACCTGTCAGCTTCTACGTTCTCTCCTGATGGAAGAGTTTTTCAAGTTGAATATGCTA
TGAAGGCTGTAGAAAATAGTAGTACAGCTATTGGGATCAGATGTAAAGATGGTGTTGTCTTTGG
AGTAGAAAAATTAGTGCTGTCTAAACTTTATGAAGAAGGTTCCAATAAACGACTTTTTAATGTT
GATCGGCATGTTGGAATGGCTGTAGCAGGTTTGTTGGCAGATGCTCGTTCTTTAGCAGACATAG
CAAGAGAAGAGGCTTCCAACTTTAGATCTAATTTTGGCTACAACATTCCACTAAAACATCTTGC
AGACAGAGTGGCTATGTATGTACATGCTTACACACTCTACAGTGCTGTTAGACCTTTTGGCTGC
AGTTTCATGTTAGGATCTTACAGTGTGAATGATGGTGCACAGCTCTACATGATTGACCCATCAG
GTGTTTCATATGGTTATTGGGGCTGCGCCATTGGCAAAGCCAGGCAAGCTGCAAAGACAGAAAT
AGAAAAACTTCAGATGAAAGAAATGACCTGCCGTGATGTTGTTAAAGAAGTTGCAAAAATAATT
TACATAGTACATGATGAAGTTAAAGATAAAGCTTTTGAACTAGAGCTCAGCTGGGTTGGTGAAC
TAACTAAAGGAAGACATGAAATTGTTCCAAAAGATATAAGGGAAGAAGCAGAGAAATATGCTAA
GGAATCTTTGAAGGAAGAGGATGAATCAGATGATGATAATATGTAACATTTACTTCAGCATCTA
TTCTATAACAGTTCCTTGTAACTTTAGCCCCTGACCAGTTTTCATTAAATTTTTGACTTGTAGC
CACT

hide sequence

RefSeq Acc Id:

XM_021724757 ⟹ XP_021580432

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	71,519,504 - 71,540,960 (-)	NCBI
SpeTri2.0	NW_004936495	2,650,688 - 2,672,192 (+)	NCBI

Sequence:

show sequence

GAGGGCTTGTTACTAGTCTGCGCGGTGCGGAGCTTGTAGGGAAAGTGCTTTGGGCCTGGAACCT
CTACACATCCCGGTGGTTTTAGCACGATGAGCTCCATCGGCACCGGGTATGACCTGTCAGCTTC
TACGTTCTCTCCTGATGGAAGAGTTTTTCAAGTTGAATATGCTATGAAGGCTGTAGAAAATAGT
AGCTATTGGGATCAGATGTAAAGATGGTGTTGTCTTTGGAGTAGAAAAATTAGTGCTGTCTAAA
CTTTATGAAGAAGGTTCCAATAAACGACTTTTTAATGTTGATCGGCATGTTGGAATGGCTGTAG
CAGGTTTGTTGGCAGATGCTCGTTCTTTAGCAGACATAGCAAGAGAAGAGGCTTCCAACTTTAG
ATCTAATTTTGGCTACAACATTCCACTAAAACATCTTGCAGACAGAGTGGCTATGTATGTACAT
GCTTACACACTCTACAGTGCTGTTAGACCTTTTGGCTGCAGTTTCATGTTAGGATCTTACAGTG
TGAATGATGGTGCACAGCTCTACATGATTGACCCATCAGGTGTTTCATATGGTTATTGGGGCTG
CGCCATTGGCAAAGCCAGGCAAGCTGCAAAGACAGAAATAGAAAAACTTCAGATGAAAGAAATG
ACCTGCCGTGATGTTGTTAAAGAAGTTGCAAAAATAATTTACATAGTACATGATGAAGTTAAAG
ATAAAGCTTTTGAACTAGAGCTCAGCTGGGTTGGTGAACTAACTAAAGGAAGACATGAAATTGT
TCCAAAAGATATAAGGGAAGAAGCAGAGAAATATGCTAAGGAATCTTTGAAGGAAGAGGATGAA
TCAGATGATGATAATATGTAACATTTACTTCAGCATCTATTCTATAACAGTTCCTTGTAACTTT
AGCCCCTGACCAGTTTTCATTAAATTTTTGACTTGTAGCCACT

hide sequence

RefSeq Acc Id:

XM_040275263 ⟹ XP_040131197

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	71,519,504 - 71,540,894 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005322800	(Get FASTA)	NCBI Sequence Viewer
	XP_021580432	(Get FASTA)	NCBI Sequence Viewer
	XP_040131197	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000012133.2
GenBank Protein	KAG3261368	(Get FASTA)	NCBI Sequence Viewer
	KAG3261369	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005322800 ⟸ XM_005322743
- Peptide Label:	isoform X1
- UniProtKB:	I3ML71 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSN KRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSA VRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVK EVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM hide sequence

RefSeq Acc Id:	XP_021580432 ⟸ XM_021724757
- Peptide Label:	isoform X2
- Sequence:	show sequence MAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLG SYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHD EVKDKAFELELSWVGELTKGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM hide sequence

RefSeq Acc Id:	XP_040131197 ⟸ XM_040275263
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSSTOP00000012133 ⟸ ENSSTOT00000013540

Protein Domains

Proteasome alpha-type subunits

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000013539	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000013540.3	UniProtKB/TrEMBL
Gene3D-CATH	3.60.20.10	UniProtKB/TrEMBL
InterPro	Ntn_hydrolases_N	UniProtKB/TrEMBL
	Proteasome_alpha-type	UniProtKB/TrEMBL
	Proteasome_asu_N	UniProtKB/TrEMBL
	Proteasome_sua/b	UniProtKB/TrEMBL
NCBI Gene	Psma3	ENTREZGENE
PANTHER	PROTEASOME SUBUNIT ALPHA/BETA	UniProtKB/TrEMBL
	PTHR11599:SF10	UniProtKB/TrEMBL
Pfam	Proteasome	UniProtKB/TrEMBL
	Proteasome_A_N	UniProtKB/TrEMBL
PROSITE	PROTEASOME_ALPHA_1	UniProtKB/TrEMBL
	PROTEASOME_ALPHA_2	UniProtKB/TrEMBL
SMART	Proteasome_A_N	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56235	UniProtKB/TrEMBL
UniProt	I3ML71	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-09-03	Psma3	proteasome 20S subunit alpha 3	Psma3	proteasome subunit alpha 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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