Itgb3 (integrin subunit beta 3) - Rat Genome Database

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Gene: Itgb3 (integrin subunit beta 3) Ictidomys tridecemlineatus
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Symbol: Itgb3
Name: integrin subunit beta 3
RGD ID: 12518190
Description: ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); fibrinogen binding (ortholog); fibroblast growth factor binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); blood coagulation, fibrin clot formation (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; eptifibatide pharmacodynamics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute myeloid leukemia (ortholog); Arterial Occlusive Diseases (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin beta-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560216,320,810 - 16,379,027 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365412,815,738 - 2,871,035 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365412,822,789 - 2,871,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute myeloid leukemia  (ISO)
Arterial Occlusive Diseases  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (ISO)
Banti's Syndrome  (ISO)
Bronchial Hyperreactivity  (ISO)
Carotid Artery Injuries  (ISO)
carotid artery thrombosis  (ISO)
carotid stenosis  (ISO)
Cerebral Hemorrhage  (ISO)
colorectal carcinoma  (ISO)
Coronary Disease  (ISO)
coronary thrombosis  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
focal segmental glomerulosclerosis  (ISO)
genetic disease  (ISO)
Glanzmann Thrombasthenia 1  (ISO)
Glanzmann Thrombasthenia 2  (ISO)
Glanzmann's thrombasthenia  (ISO)
Gliosis  (ISO)
glomerulonephritis  (ISO)
Graves' disease  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Hantavirus Infections  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hip Fractures  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
Neonatal Alloimmune Thrombocytopenia  (ISO)
Neoplasm Metastasis  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
Pathologic Constriction  (ISO)
Plaque, Atherosclerotic  (ISO)
platelet-type bleeding disorder 16  (ISO)
Platelet-Type Bleeding Disorder 24  (ISO)
pneumonia  (ISO)
Posttransfusion Purpura  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
Stroke  (ISO)
Sudden Cardiac Death  (ISO)
thrombocytopenia  (ISO)
Thrombocytopenic Purpura  (ISO)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
Ulcer  (ISO)
Venous Thrombosis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
apolipoprotein A-I-mediated signaling pathway  (IEA)
apoptotic cell clearance  (IEA)
blood coagulation, fibrin clot formation  (IEA,ISO)
cell adhesion  (IEA)
cell adhesion mediated by integrin  (IEA)
cell migration  (IEA)
cell-matrix adhesion  (IEA,ISO)
cell-substrate adhesion  (IEA)
cell-substrate junction assembly  (IEA,ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (IEA,ISO)
cellular response to xenobiotic stimulus  (ISO)
embryo implantation  (ISO)
heterotypic cell-cell adhesion  (IEA)
integrin-mediated signaling pathway  (IEA)
maintenance of postsynaptic specialization structure  (ISO)
mesodermal cell differentiation  (IEA)
negative chemotaxis  (IEA)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of lipid storage  (IEA)
negative regulation of lipid transport  (IEA)
negative regulation of lipoprotein metabolic process  (IEA)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of macrophage derived foam cell differentiation  (IEA)
platelet activation  (IEA)
platelet aggregation  (IEA,ISO)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell migration  (IEA)
positive regulation of cell-matrix adhesion  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast migration  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of glomerular mesangial cell proliferation  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of osteoblast proliferation  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (IEA,ISO)
positive regulation of T cell migration  (IEA)
regulation of actin cytoskeleton organization  (IEA)
regulation of extracellular matrix organization  (IEA,ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of postsynaptic neurotransmitter receptor diffusion trapping  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (IEA)
regulation of protein localization  (IEA)
regulation of protein tyrosine kinase activity  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
regulation of serotonin uptake  (IEA)
regulation of trophoblast cell migration  (IEA,ISO)
response to activity  (ISO)
response to platelet-derived growth factor  (ISO)
smooth muscle cell migration  (IEA)
substrate adhesion-dependent cell spreading  (IEA)
symbiont entry into host cell  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Itgb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560216,320,810 - 16,379,027 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365412,815,738 - 2,871,035 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365412,822,789 - 2,871,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381747,253,827 - 47,313,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1747,253,827 - 47,313,743 (+)EnsemblGRCh38hg38GRCh38
GRCh371745,331,193 - 45,391,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361742,686,207 - 42,745,076 (+)NCBINCBI36Build 36hg18NCBI36
Build 341742,686,206 - 42,745,076NCBI
Celera1741,781,276 - 41,840,192 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1740,709,287 - 40,768,167 (+)NCBIHuRef
CHM1_11745,396,156 - 45,455,032 (+)NCBICHM1_1
T2T-CHM13v2.01748,116,181 - 48,176,126 (+)NCBIT2T-CHM13v2.0
Itgb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911104,498,826 - 104,561,302 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11104,498,826 - 104,561,302 (+)EnsemblGRCm39 Ensembl
GRCm3811104,608,000 - 104,670,476 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11104,608,000 - 104,670,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711104,469,314 - 104,531,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611104,424,146 - 104,483,465 (+)NCBIMGSCv36mm8
Celera11116,336,310 - 116,392,711 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.84NCBI
Itgb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81090,009,927 - 90,067,787 (+)NCBIGRCr8
mRatBN7.21089,509,917 - 89,564,679 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1089,509,989 - 89,564,679 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1094,545,884 - 94,600,315 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01094,009,074 - 94,063,507 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01089,414,016 - 89,475,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01092,667,869 - 92,783,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1092,667,869 - 92,783,410 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01092,424,545 - 92,538,859 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1088,202,821 - 88,257,185 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Itgb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554789,788,149 - 9,823,746 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554789,788,192 - 9,830,254 (-)NCBIChiLan1.0ChiLan1.0
ITGB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21917,697,521 - 17,760,403 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11719,665,154 - 19,725,972 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01710,134,450 - 10,194,596 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11710,353,111 - 10,388,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1710,353,111 - 10,392,382 (-)Ensemblpanpan1.1panPan2
ITGB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.199,179,667 - 9,231,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl99,182,562 - 9,231,451 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha911,065,645 - 11,114,120 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0910,772,116 - 10,823,763 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl910,772,333 - 10,825,024 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.199,787,282 - 9,835,753 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0917,686,480 - 17,734,963 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0917,635,354 - 17,683,846 (+)NCBIUU_Cfam_GSD_1.0
ITGB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,693,514 - 16,752,292 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,694,466 - 16,752,228 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21216,718,915 - 16,775,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11659,372,171 - 59,431,434 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1659,374,889 - 59,410,857 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607730,082,743 - 30,143,493 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,895,914 - 1,952,665 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248491,895,378 - 1,952,755 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000002837   ⟹   ENSSTOP00000002538
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365412,815,738 - 2,871,035 (+)Ensembl
RefSeq Acc Id: XM_040268642   ⟹   XP_040124576
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560216,320,810 - 16,379,027 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040124576 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002538.3
GenBank Protein KAG3268706 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_040124576   ⟸   XM_040268642
- UniProtKB: I3M175 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000002538   ⟸   ENSSTOT00000002837

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002839 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002837.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
  4.10.1240.30 UniProtKB/TrEMBL
  Cytochrome c1, transmembrane anchor, C-terminal UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  ligand-binding face of the semaphorins, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
InterPro EGF_extracell UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_beta_N UniProtKB/TrEMBL
  Integrin_bsu UniProtKB/TrEMBL
  Integrin_bsu_cyt_dom UniProtKB/TrEMBL
  Integrin_bsu_tail UniProtKB/TrEMBL
  Integrin_bsu_tail_dom_sf UniProtKB/TrEMBL
  Integrin_bsu_VWA UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene Itgb3 ENTREZGENE
PANTHER PTHR10082 UniProtKB/TrEMBL
  PTHR10082:SF25 UniProtKB/TrEMBL
Pfam EGF_2 UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  Integrin_beta UniProtKB/TrEMBL
  PSI_integrin UniProtKB/TrEMBL
PIRSF Integrin_B UniProtKB/TrEMBL
PRINTS INTEGRINB UniProtKB/TrEMBL
PROSITE INTEGRIN_BETA UniProtKB/TrEMBL
SMART INB UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Plexin repeat UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69687 UniProtKB/TrEMBL
UniProt I3M175 ENTREZGENE, UniProtKB/TrEMBL