Prkcz (protein kinase C zeta) - Rat Genome Database

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Gene: Prkcz (protein kinase C zeta) Ictidomys tridecemlineatus
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Symbol: Prkcz
Name: protein kinase C zeta
RGD ID: 12517129
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); phospholipase binding (ortholog); potassium channel regulator activity (ortholog); INVOLVED IN activation of phospholipase D activity (ortholog); activation of protein kinase B activity (ortholog); cell migration (ortholog); PARTICIPATES IN adenosine signaling pathway; angiotensin II signaling pathway; ceramide signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); chromosome 1p36 deletion syndrome (ortholog); congenital myasthenic syndrome 8 (ortholog); FOUND IN cell leading edge (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,082,811 - 28,162,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367371,303,887 - 1,321,944 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367371,303,502 - 1,383,135 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase D activity  (ISO)
activation of protein kinase B activity  (ISO)
cell migration  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to insulin stimulus  (ISO)
establishment of cell polarity  (ISO)
intracellular signal transduction  (ISO)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
membrane depolarization  (ISO)
membrane hyperpolarization  (ISO)
microtubule cytoskeleton organization  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of hydrolase activity  (ISO)
negative regulation of insulin receptor signaling pathway  (IEA)
negative regulation of peptidyl-tyrosine phosphorylation  (IEA)
negative regulation of protein-containing complex assembly  (IEA)
neuron projection extension  (IEA,ISO)
peptidyl-serine phosphorylation  (IEA,ISO)
phosphorylation  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-13 production  (IEA)
positive regulation of interleukin-4 production  (IEA)
positive regulation of interleukin-5 production  (IEA)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of protein transport  (ISO)
positive regulation of synaptic transmission  (ISO)
positive regulation of T-helper 2 cell cytokine production  (IEA)
positive regulation of T-helper 2 cell differentiation  (IEA)
protein kinase C signaling  (ISO)
protein localization  (ISO)
protein localization to plasma membrane  (IEA,ISO)
protein phosphorylation  (IEA,ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
signal transduction  (ISO)
vesicle transport along microtubule  (ISO)

References

Genomics

Comparative Map Data
Prkcz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,082,811 - 28,162,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367371,303,887 - 1,321,944 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367371,303,502 - 1,383,135 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,048,504 - 2,185,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12,050,411 - 2,185,395 (+)EnsemblGRCh38hg38GRCh38
GRCh3711,981,850 - 2,116,834 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,971,769 - 2,106,694 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412,014,070 - 2,148,996NCBI
Celera1476,373 - 611,123 (-)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef11,259,190 - 1,392,660 (+)NCBIHuRef
CHM1_111,969,035 - 2,101,756 (+)NCBICHM1_1
T2T-CHM13v2.011,485,930 - 1,620,370 (+)NCBIT2T-CHM13v2.0
Prkcz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,344,575 - 155,445,885 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,344,586 - 155,445,818 (-)EnsemblGRCm39 Ensembl
GRCm384155,260,118 - 155,361,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,260,129 - 155,361,361 (-)EnsemblGRCm38mm10GRCm38
MGSCv374154,634,229 - 154,735,500 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364154,103,920 - 154,205,191 (-)NCBIMGSCv36mm8
Celera4157,534,125 - 157,635,425 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.17NCBI
Prkcz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25165,817,786 - 165,930,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,819,466 - 165,930,367 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5168,525,295 - 168,635,221 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05170,346,708 - 170,456,637 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05170,309,234 - 170,419,166 (-)NCBIRnor_WKY
Rnor_6.05172,658,071 - 172,769,492 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,658,748 - 172,769,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,116,787 - 176,228,206 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,061,825 - 172,172,793 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,072,319 - 172,179,534 (-)NCBI
Celera5164,023,257 - 164,132,959 (-)NCBICelera
Cytogenetic Map5q36NCBI
Prkcz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,947,579 - 9,021,702 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,947,579 - 9,021,702 (-)NCBIChiLan1.0ChiLan1.0
PRKCZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111,918,653 - 2,046,236 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11,920,219 - 2,045,855 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01763,942 - 901,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRKCZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,012,020 - 57,113,346 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,012,070 - 57,112,664 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,089,028 - 57,190,338 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0557,215,092 - 57,316,595 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,214,279 - 57,316,691 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,206,002 - 57,307,319 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,098,518 - 57,199,838 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,488,367 - 57,589,745 (+)NCBIUU_Cfam_GSD_1.0
PRKCZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,068,577 - 64,163,472 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,073,343 - 64,159,187 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,385,685 - 58,460,767 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,367,309 - 129,502,681 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,365,679 - 129,485,818 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605433,720,444 - 33,872,633 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkcz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,759,770 - 7,847,208 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248187,758,192 - 7,846,950 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000012804   ⟹   ENSSTOP00000011476
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049367371,303,887 - 1,321,944 (-)Ensembl
RefSeq Acc Id: XM_021735892   ⟹   XP_021591567
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505828,082,811 - 28,162,827 (+)NCBI
SpeTri2.0NW_0049367371,303,502 - 1,383,135 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021735893   ⟹   XP_021591568
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505828,091,812 - 28,162,827 (+)NCBI
SpeTri2.0NW_0049367371,303,502 - 1,374,105 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021735894   ⟹   XP_021591569
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505828,090,782 - 28,162,827 (+)NCBI
SpeTri2.0NW_0049367371,303,502 - 1,375,134 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021735895   ⟹   XP_021591570
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505828,091,218 - 28,162,827 (+)NCBI
SpeTri2.0NW_0049367371,303,502 - 1,374,692 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040287776   ⟹   XP_040143710
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505828,133,586 - 28,162,827 (+)NCBI
RefSeq Acc Id: XM_040287777   ⟹   XP_040143711
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505828,091,520 - 28,162,827 (+)NCBI
RefSeq Acc Id: XM_040287778   ⟹   XP_040143712
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505828,130,772 - 28,162,827 (+)NCBI
RefSeq Acc Id: XM_040287779   ⟹   XP_040143713
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505828,091,867 - 28,162,827 (+)NCBI
RefSeq Acc Id: XR_005734886
RefSeq Status:
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505828,133,586 - 28,162,827 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_021591567   ⟸   XM_021735892
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_021591569   ⟸   XM_021735894
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021591570   ⟸   XM_021735895
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021591568   ⟸   XM_021735893
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_040143711   ⟸   XM_040287777
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040143713   ⟸   XM_040287779
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040143712   ⟸   XM_040287778
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040143710   ⟸   XM_040287776
- Peptide Label: isoform X1
RefSeq Acc Id: ENSSTOP00000011476   ⟸   ENSSTOT00000012804

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012801 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000011476 ENTREZGENE
  ENSSTOP00000011476.3 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012804.3 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Prkcz ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt I3MJU3_ICTTR UniProtKB/TrEMBL