Cpa3 (carboxypeptidase A3) - Rat Genome Database

Name: Cpa3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Cpa3 (carboxypeptidase A3) Ictidomys tridecemlineatus

Analyze

Symbol:

Cpa3

Name:

carboxypeptidase A3

RGD ID:

12514877

Description:

ENCODES a protein that exhibits carboxypeptidase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN regulation of angiotensin levels in blood (ortholog); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); glycogen storage disease XV (ortholog); FOUND IN extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

mast cell carboxypeptidase A

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CPA3 (carboxypeptidase A3)	NCBI	Ortholog
Mus musculus (house mouse):	Cpa3 (carboxypeptidase A3, mast cell)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cpa3 (carboxypeptidase A3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cpa3 (carboxypeptidase A3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CPA3 (carboxypeptidase A3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CPA3 (carboxypeptidase A3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CPA3 (carboxypeptidase A3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CPA3 (carboxypeptidase A3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cpa3 (carboxypeptidase A3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	83,015,494 - 83,041,913 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936519	6,692,513 - 6,718,425 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936519	6,692,466 - 6,718,480 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

genetic disease (ISO)

glycogen storage disease XV (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA)

regulation of angiotensin levels in blood (IEA,ISO)

Cellular Component

extracellular space (IEA)

Molecular Function

carboxypeptidase activity (IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

metallocarboxypeptidase activity (IEA)

metallopeptidase activity (IEA)

peptidase activity (IEA)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cpa3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	83,015,494 - 83,041,913 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936519	6,692,513 - 6,718,425 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936519	6,692,466 - 6,718,480 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CPA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	148,865,296 - 148,897,203 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	148,865,296 - 148,897,203 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	148,583,083 - 148,614,990 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	150,065,774 - 150,097,552 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	150,065,781 - 150,097,560	NCBI
Celera	3	146,993,118 - 147,024,950 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI
HuRef	3	145,955,149 - 145,986,993 (+)	NCBI		HuRef
CHM1_1	3	148,545,876 - 148,577,717 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	151,616,046 - 151,647,965 (+)	NCBI		T2T-CHM13v2.0

Cpa3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	20,269,780 - 20,296,373 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	20,269,784 - 20,296,345 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	20,215,616 - 20,242,209 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	20,215,620 - 20,242,181 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	20,115,515 - 20,142,080 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	20,407,673 - 20,434,227 (-)	NCBI		MGSCv36	mm8
Celera	3	20,204,832 - 20,231,395 (-)	NCBI		Celera
Cytogenetic Map	3	A2	NCBI
cM Map	3	6.25	NCBI

Cpa3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	104,641,619 - 104,673,253 (-)	NCBI		GRCr8
mRatBN7.2	2	102,712,483 - 102,744,219 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	102,712,589 - 102,744,203 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	109,232,601 - 109,264,222 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	107,353,762 - 107,385,392 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	102,306,747 - 102,338,386 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	105,016,798 - 105,047,989 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	105,016,626 - 105,047,984 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	124,745,511 - 124,777,636 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	105,368,835 - 105,402,657 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	105,313,798 - 105,347,605 (-)	NCBI
Celera	2	98,081,042 - 98,112,943 (-)	NCBI		Celera
RH 3.4 Map	2	729.9	RGD
Cytogenetic Map	2	q24	NCBI

Cpa3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955474	8,602,958 - 8,626,436 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955474	8,602,958 - 8,626,436 (-)	NCBI	ChiLan1.0	ChiLan1.0

CPA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	146,760,053 - 146,793,151 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	146,764,783 - 146,797,881 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	145,889,140 - 145,921,462 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	153,468,252 - 153,500,113 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	153,468,071 - 153,500,333 (+)	Ensembl	panpan1.1		panPan2

CPA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	43,718,987 - 43,748,335 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	43,679,361 - 43,748,213 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	43,583,372 - 43,612,478 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	44,346,568 - 44,375,767 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	44,276,898 - 44,375,642 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	43,928,939 - 43,958,267 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	43,983,539 - 44,012,801 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	44,237,426 - 44,266,751 (+)	NCBI		UU_Cfam_GSD_1.0

CPA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	13	89,093,296 - 89,132,088 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	97,084,980 - 97,127,970 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CPA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	41,807,728 - 41,839,889 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	41,807,727 - 41,839,819 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	14,650,383 - 14,682,474 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cpa3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	26,098,373 - 26,124,104 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	26,098,309 - 26,124,203 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005325718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000008364 ⟹ ENSSTOP00000007497

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936519	6,692,513 - 6,718,425 (-)	Ensembl

RefSeq Acc Id:

XM_005325718 ⟹ XP_005325775

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	83,015,494 - 83,041,913 (+)	NCBI
SpeTri2.0	NW_004936519	6,692,466 - 6,718,480 (-)	NCBI

Sequence:

show sequence

GGCTGGGGCATAAGAGTGGCAGAGGAGAGGGTCTCAAGTCAAGCAAAGAGGAACCATGAGGCTC
CTCCTGCCTGTGGCTCTGCTGGCCACCACCACTGCGATTGCTCCCGTCCACTTCGACAGGGAGA
AGGTGGTCCGTGTGAAGCCCCAGGATGAAAACCAAGTGAGCATCATGAAGAATTTGGCCAAAGA
CAATGAGCTTGACTTCTGGTATCCAGATGCCATCGACCATGTAGCTGCTAACATGACAGTGGAT
TTCCGAGTTAGTGGGAAAGAATTTCAATCCATCCAGTCTGCCTTGGATCAAAACAGAATGCACT
ATGAAATCCTGATTGATAATCTACAAGAAGAAATCGAGAAACAGTTTGATGTTAAAGAAGCTGT
CCCAGGCAGGCACAGTTATGCCAAATACAATAACTGGGACAAGATTGTAGCCTGGACTGAAAAA
ATGGTGGATAAACATCCTGAAATGGTCTCTCGTATTAAAATCGGATCCACTTTTGAAGATAATC
CGCTGTACGTTCTCAAGATTGGGAAAAAAGATGAAAGAAGAAAGGCTGTCTTCATGGACTGTGG
CATTCATGCACAAGAATGGATCTCCCCAGCATTCTGCCAGTGGTTTGTCTATCAGGCAGCAAAA
AGTTATGGAAAAAACAAAATTATGACCAAAATCTTGGACCGAATGAATTTTTATGTTCTTCCTG
TGTTCAACGTGGATGGATATATTTGGTCATGGACACAGGACCGCATGTGGAAAAAAAATCGTTC
CAAGAACCACAACTCCAAGTGCGTGGGCACTGACCTCAACAGGAATTTTAATGTGTCTTGGCAT
TCTTCTCCTAACACCGATGACCCATGTCAGGACACCTATCGGGGCCCTGCTCCAGAGTCGGAGA
AAGAGACAAAAGCTGTTGCTGACTTCATTCGCAGCCACCTGAAATCAGTCAGGGCCTACATCTC
CTTCCATTCCTACTCCCAAATGCTACTGTTTCCCTACGGCTACACGTTAAAGCTGCCACCCAAC
CACGAGGACCTGGCCAAAGTTGCTAGGATTGGCACTGATGTTCTATCAACTCGATATGAAACCC
AGTACATTTATGGCCCAATAGCATCGACAGCTTACCCGACATCAGGTTCTTCTTTAGACTGGGC
TTACAATCTGGGCATCAAACACACATTTGCCTTTGAGCTCCGTGATAAAGGCAGATTTGGTTTT
CTCCTTCCAGAATCTCGGATAAAGTCAACCTGTAAAGAGACTATGCTGGCTGTCAAGTTTATTG
CCAAGTACATTCTCAGGCATACTTCCTAAACAACTGCTCTCAGTTTAGAAAACACCAATTAACC
TGTGTGTGTGTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005325775	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000007497.3
GenBank Protein	KAG3270803	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005325775 ⟸ XM_005325718

- UniProtKB:

I3MBH9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRLLLPVALLATTTAIAPVHFDREKVVRVKPQDENQVSIMKNLAKDNELDFWYPDAIDHVAANM
TVDFRVSGKEFQSIQSALDQNRMHYEILIDNLQEEIEKQFDVKEAVPGRHSYAKYNNWDKIVAW
TEKMVDKHPEMVSRIKIGSTFEDNPLYVLKIGKKDERRKAVFMDCGIHAQEWISPAFCQWFVYQ
AAKSYGKNKIMTKILDRMNFYVLPVFNVDGYIWSWTQDRMWKKNRSKNHNSKCVGTDLNRNFNV
SWHSSPNTDDPCQDTYRGPAPESEKETKAVADFIRSHLKSVRAYISFHSYSQMLLFPYGYTLKL
PPNHEDLAKVARIGTDVLSTRYETQYIYGPIASTAYPTSGSSLDWAYNLGIKHTFAFELRDKGR
FGFLLPESRIKSTCKETMLAVKFIAKYILRHTS

hide sequence

RefSeq Acc Id:

ENSSTOP00000007497 ⟸ ENSSTOT00000008364

Protein Domains

Peptidase M14 carboxypeptidase A

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000008364	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000008364.3	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.340	UniProtKB/TrEMBL
	Zn peptidases	UniProtKB/TrEMBL
InterPro	M14A-like_propep	UniProtKB/TrEMBL
	M14A_act_pep	UniProtKB/TrEMBL
	Peptidase_M14	UniProtKB/TrEMBL
NCBI Gene	Cpa3	ENTREZGENE
PANTHER	MAST CELL CARBOXYPEPTIDASE A	UniProtKB/TrEMBL
	PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B	UniProtKB/TrEMBL
Pfam	Peptidase_M14	UniProtKB/TrEMBL
	Propep_M14	UniProtKB/TrEMBL
PRINTS	CRBOXYPTASEA	UniProtKB/TrEMBL
PROSITE	CARBOXYPEPT_ZN_1	UniProtKB/TrEMBL
	CARBOXYPEPT_ZN_2	UniProtKB/TrEMBL
SMART	Zn_pept	UniProtKB/TrEMBL
Superfamily-SCOP	Protease propeptides/inhibitors	UniProtKB/TrEMBL
	Zn-dependent exopeptidases	UniProtKB/TrEMBL
UniProt	I3MBH9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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