Cdk19 (cyclin dependent kinase 19) - Rat Genome Database

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Gene: Cdk19 (cyclin dependent kinase 19) Ictidomys tridecemlineatus
Analyze
Symbol: Cdk19
Name: cyclin dependent kinase 19
RGD ID: 12507365
Description: ENCODES a protein that exhibits ATP binding (inferred); protein kinase activity (inferred); protein serine/threonine kinase activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); positive regulation of apoptotic process (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 87 (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclin dependent kinase 19, transcript variant X1; cyclin dependent kinase 19, transcript variant X2; cyclin-dependent kinase 19
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946102,167,888 - 102,292,372 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365646,442,809 - 6,567,210 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365646,443,041 - 6,584,767 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cdk19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946102,167,888 - 102,292,372 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365646,442,809 - 6,567,210 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365646,443,041 - 6,584,767 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386110,609,978 - 110,815,855 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6110,609,978 - 110,815,958 (-)EnsemblGRCh38hg38GRCh38
GRCh376110,931,181 - 111,137,058 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366111,037,874 - 111,243,105 (-)NCBINCBI36Build 36hg18NCBI36
Build 346111,037,873 - 111,243,105NCBI
Celera6111,677,771 - 111,883,024 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6108,502,782 - 108,707,560 (-)NCBIHuRef
CHM1_16111,194,368 - 111,399,578 (-)NCBICHM1_1
T2T-CHM13v2.06111,788,546 - 111,994,459 (-)NCBIT2T-CHM13v2.0
Cdk19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391040,225,283 - 40,359,814 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1040,215,560 - 40,359,814 (+)EnsemblGRCm39 Ensembl
GRCm381040,349,287 - 40,483,818 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1040,339,564 - 40,483,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv371040,069,114 - 40,203,624 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361040,038,753 - 40,171,561 (+)NCBIMGSCv36mm8
Celera1041,236,080 - 41,370,778 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1021.94NCBI
Cdk19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82045,324,911 - 45,465,121 (+)NCBIGRCr8
mRatBN7.22043,770,409 - 43,910,629 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,770,409 - 43,910,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2045,519,393 - 45,659,600 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02045,178,592 - 45,318,717 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02045,927,534 - 46,067,387 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02045,458,499 - 45,598,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2045,458,558 - 45,598,798 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02047,178,053 - 47,318,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42044,527,463 - 44,670,028 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12044,550,571 - 44,690,526 (+)NCBI
Celera2044,473,908 - 44,614,279 (+)NCBICelera
Cytogenetic Map20q12NCBI
Cdk19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541135,312,722 - 35,412,246 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541135,312,722 - 35,411,951 (-)NCBIChiLan1.0ChiLan1.0
CDK19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25130,619,449 - 130,825,485 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16128,505,435 - 128,711,500 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06108,413,832 - 108,619,053 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16112,483,434 - 112,686,987 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6112,483,434 - 112,686,987 (-)Ensemblpanpan1.1panPan2
CDK19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11267,227,374 - 67,369,481 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1267,231,463 - 67,327,084 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1267,045,409 - 67,207,137 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01268,105,399 - 68,267,587 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1268,107,897 - 68,266,935 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11267,456,135 - 67,618,065 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01267,302,282 - 67,464,163 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01267,580,480 - 67,742,370 (-)NCBIUU_Cfam_GSD_1.0
CDK19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl176,589,052 - 76,793,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1176,589,050 - 76,793,476 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,115,818 - 86,230,304 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11363,069,270 - 63,294,012 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1363,069,864 - 63,293,998 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604035,373,637 - 35,589,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249161,625,073 - 1,812,296 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249161,625,330 - 1,812,026 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000019802   ⟹   ENSSTOP00000019946
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365646,442,809 - 6,567,210 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000031406   ⟹   ENSSTOP00000029955
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365646,446,994 - 6,541,146 (-)Ensembl
RefSeq Acc Id: XM_005330182   ⟹   XP_005330239
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946102,167,888 - 102,292,371 (-)NCBI
SpeTri2.0NW_0049365646,443,041 - 6,584,767 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021729732   ⟹   XP_021585407
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946102,167,888 - 102,292,370 (-)NCBI
SpeTri2.0NW_0049365646,443,041 - 6,567,210 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040283212   ⟹   XP_040139146
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946102,167,888 - 102,292,372 (-)NCBI
RefSeq Acc Id: XM_040283214   ⟹   XP_040139148
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946102,167,888 - 102,220,052 (-)NCBI
RefSeq Acc Id: XP_005330239   ⟸   XM_005330182
- Peptide Label: isoform X1
- UniProtKB: I3N6F0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021585407   ⟸   XM_021729732
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_040139146   ⟸   XM_040283212
- Peptide Label: isoform X2
- UniProtKB: A0A287D8S3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139148   ⟸   XM_040283214
- Peptide Label: isoform X4
Ensembl Acc Id: ENSSTOP00000019946   ⟸   ENSSTOT00000019802
Ensembl Acc Id: ENSSTOP00000029955   ⟸   ENSSTOT00000031406
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000024165 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000019802.2 UniProtKB/TrEMBL
  ENSSTOT00000031406.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CDK UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Cdk19 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 19 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287D8S3 ENTREZGENE, UniProtKB/TrEMBL
  I3N6F0 ENTREZGENE, UniProtKB/TrEMBL