Ftcd (formimidoyltransferase cyclodeaminase)

Gene: Ftcd (formimidoyltransferase cyclodeaminase) Ictidomys tridecemlineatus

Analyze

Symbol:

Ftcd

Name:

formimidoyltransferase cyclodeaminase

RGD ID:

12506388

Description:

ENCODES a protein that exhibits folic acid binding (inferred); formimidoyltetrahydrofolate cyclodeaminase activity (inferred); glutamate formimidoyltransferase activity (inferred); INVOLVED IN cytoskeleton organization (ortholog); PARTICIPATES IN folate metabolic pathway; hereditary folate malabsorption pathway; histidine metabolic pathway; ASSOCIATED WITH autistic disorder (ortholog); Axenfeld-Rieger syndrome type 3 (ortholog); Bethlem myopathy (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum-Golgi intermediate compartment (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

formimidoyltransferase cyclodeaminase, transcript variant X1; formimidoyltransferase cyclodeaminase, transcript variant X2; formimidoyltransferase-cyclodeaminase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	38,739,431 - 38,755,168 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936778	375,800 - 390,554 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936778	375,800 - 390,764 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Axenfeld-Rieger syndrome type 3 (ISO)

Bethlem myopathy (ISO)

Bethlem Myopathy 1A (ISO)

Burkitt lymphoma (ISO)

cataract 9 multiple types (ISO)

Collagen VI-related Myopathy (ISO)

developmental and epileptic encephalopathy 30 (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

glutamate formiminotransferase deficiency (ISO)

homocystinuria (ISO)

intellectual disability (ISO)

myoepithelioma (ISO)

Myosclerosis, Autosomal Recessive (ISO)

primary ciliary dyskinesia (ISO)

progressive myoclonus epilepsy (ISO)

Ullrich Congenital Muscular Dystrophy 1A (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoskeleton organization (ISO)

histidine catabolic process to glutamate and formamide (IEA)

histidine catabolic process to glutamate and formate (IEA)

histidine metabolic process (IEA)

Cellular Component

centriole (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

cytosol (IEA)

endoplasmic reticulum (ISO)

endoplasmic reticulum-Golgi intermediate compartment (ISO)

Golgi apparatus (IEA)

Golgi membrane (IEA)

plasma membrane (IEA)

smooth endoplasmic reticulum membrane (IEA)

Molecular Function

folic acid binding (IEA)

formimidoyltetrahydrofolate cyclodeaminase activity (IEA)

glutamate formimidoyltransferase activity (IEA)

lyase activity (IEA)

microtubule binding (IEA)

protein binding (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

folate metabolic pathway (ISO)

hereditary folate malabsorption pathway (ISO)

histidine metabolic pathway (ISO)

histidinemia pathway (ISO)

methotrexate pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Ftcd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	38,739,431 - 38,755,168 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936778	375,800 - 390,554 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936778	375,800 - 390,764 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FTCD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	46,136,262 - 46,155,579 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	46,136,160 - 46,155,579 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	47,556,176 - 47,575,493 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	46,380,604 - 46,399,909 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	46,381,123 - 46,399,909	NCBI
Celera	21	32,668,510 - 32,687,862 (-)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	32,937,193 - 32,957,524 (-)	NCBI		HuRef
CHM1_1	21	47,116,995 - 47,136,320 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	21	44,514,323 - 44,534,996 (-)	NCBI		T2T-CHM13v2.0

Ftcd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	76,411,482 - 76,426,172 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	76,411,482 - 76,426,172 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	76,575,648 - 76,590,338 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	76,575,648 - 76,590,338 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	76,038,393 - 76,053,083 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	76,019,402 - 76,033,277 (+)	NCBI		MGSCv36	mm8
Celera	10	77,620,163 - 77,635,459 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.25	NCBI

Ftcd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	12,054,710 - 12,068,219 (-)	NCBI		GRCr8
mRatBN7.2	20	12,055,203 - 12,068,717 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	12,055,208 - 12,068,735 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	12,751,494 - 12,765,024 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	12,112,414 - 12,125,946 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	12,584,199 - 12,597,724 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	12,806,957 - 12,820,466 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	12,806,957 - 12,820,466 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	14,965,126 - 14,978,635 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	12,470,291 - 12,483,807 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	12,470,516 - 12,484,034 (-)	NCBI
Celera	20	13,553,681 - 13,567,051 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

Ftcd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	42,607,872 - 42,617,166 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	42,608,249 - 42,617,167 (-)	NCBI	ChiLan1.0	ChiLan1.0

FTCD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	42,237,586 - 42,262,376 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	37,109,542 - 37,134,237 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	32,481,042 - 32,501,932 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	45,734,647 - 45,753,437 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	45,734,825 - 45,753,400 (-)	Ensembl	panpan1.1		panPan2

FTCD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	39,451,557 - 39,464,249 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	39,275,159 - 39,464,715 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	38,679,583 - 38,692,067 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	39,092,693 - 39,105,364 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	39,092,651 - 39,105,751 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	38,954,390 - 38,967,042 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	38,914,802 - 38,927,725 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	39,433,241 - 39,445,917 (-)	NCBI		UU_Cfam_GSD_1.0

FTCD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	13	218,617,763 - 218,632,226 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103220313
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	89,761,600 - 89,778,572 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	89,761,248 - 89,782,238 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	18,109,972 - 18,159,319 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ftcd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	31,276,314 - 31,289,063 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	31,279,868 - 31,288,600 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005340179	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021720073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000022402 ⟹ ENSSTOP00000023738

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936778	375,800 - 390,554 (+)	Ensembl

RefSeq Acc Id:

XM_005340179 ⟹ XP_005340236

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404971	38,739,431 - 38,755,168 (-)	NCBI
SpeTri2.0	NW_004936778	375,800 - 390,589 (+)	NCBI

Sequence:

show sequence

ATGTCCCAGCTGGTGGAGTGTGTCCCCAACTTCTCAGAGGGGACTGACCAGGAGGTGATCGGGG
CCATCTCCCAGGCCATCTCGCAGACCCCAGGCTGTGTCCTGCTGGACGTGGACGCAGGCCTCTC
CACCAACCGCACCGTCTACACCTTTGTCGGCAAGCCCGAGTGCGTGGTGGAAGGGGCTCTGAGT
GCTGCCCGCACGGCCTCCCGGCTCATCGACATGAGCAGGCACCGAGGGGAGCACCCCCGCATGG
GCGCCCTGGATGTCTGCCCCTTCATCCCAGTGAGGGGCGTCACCATGGACCAGTGTGTGCTGTG
TGCCCAGGCCTTTGGCCAGCGGCTGGCAGAGGAGCTGAAGGTGCCAGTGTACCTCTATGGTGAG
GCAGCCCGGACAGCCAGCCGCAGAACCTTGCCGGCCATCCGAGCTGGGGAGTACGAGGCCCTCC
CTGAGAAGCTCAAGCAGGCCGAATGGGAGCCTGACTTTGGCCCCAGCTGCTTTGTCCCCAGCTG
GGGGGCCACCGTCACGGGTGCACGGAAGTTCCTCATCGCATTCAACATCAACCTGCTCAGCACC
AAGGAGCAGGCCCACCGCATCGCCCTCAACCTGCGGGAGCAGGGCCGAGGGCAGCACCAGCCAG
GGCGTCTGAGGAAGGTCCAAGGCATCGGCTGGTACCTGGAGGAGAAGAATCTGGCCCAGGTGTC
CACGAACCTCCTGGACTTTGAGGTTACGGGGCTGCACACAGTCTTCGAGGAGACCTGCAGAGAA
GCCCAGGAGCTGCGCCTCCCTGTGGTGGGCTCGCAGCTGGTGGGCCTGGTGCCTCTGAAGGCTC
TGCTGGACGCGGCTGCCTTCTACTGTGACAAGGAGAACCTGTTTGTCCTGGAGGAGGAGCAACG
CATCAGGCTGGTGGTGAGCCGGCTGGGCCTGGACTCCCTGGCACCCTTCAACCCCTCAGAGAGG
GTCATTGAGTATCTGGTCCCAGACCGGCTGGAGAAGAGCCTGTTGGACATGTCCCTGCGTGCTT
TCCTCCGTGAGGTGGGCGCCCGCTCAGCCACCCCTGGGGGCGGCTCCGTGGCAGCGGCCTCTGC
AGCCATGGGTGCAGCTCTGGCCTCCATGGTGGGCCAGATGACCTACGGTCGGCGTCAGTTTGAG
CAGCTGGATGCAGTGATGCGGCGCCTGATCCCGCCCTTCCATGCAGCCCTGGCCCAGCTGACTT
CACTGGTGGACGCGGATGCCCAGGCCTTTGCCACCTACCTGGAGGCAATGAAGCTGCCCAAGAA
CACTCCTGAGGACAGGGACAGGCGCACGGCGGCCCTGCAAGAGGGGCTGAGAGGTGCAGTTGCC
GTGCCGCTGGCGCTGGCAGAAACAGTGTCACCGCTGTGGCCAGCGCTGCGAGAGCTGGCCCTGT
GTGGGAACCTGGCCTGCCAGTCCGACCTTCAGGTGGCAGCCAAAGCCTTGGAGATGGGTGTGTT
TGGTGCGTACTTCAACGTGCTCATCAACCTGAAGGACGTGAAGGACGAAGTGTTTAAGGACCAG
GTCCGCCAGCGCGCTGCCAGCCTCCTGCAGGAAGCCAAGGCCCAGGCTGCACTGGTGCTGGAGA
GCCTGGAGGCTCGGCAGGAGTGACCGCTGGTGGGCACGAGACGGCAGGAGACCTCCCTGGACGG
CATGGCCTTCAGCAGCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005340236	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000023738.1
GenBank Protein	KAG3284170	(Get FASTA)	NCBI Sequence Viewer
	KAG3284171	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005340236 ⟸ XM_005340179

- UniProtKB:

I3NH91 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSQLVECVPNFSEGTDQEVIGAISQAISQTPGCVLLDVDAGLSTNRTVYTFVGKPECVVEGALS
AARTASRLIDMSRHRGEHPRMGALDVCPFIPVRGVTMDQCVLCAQAFGQRLAEELKVPVYLYGE
AARTASRRTLPAIRAGEYEALPEKLKQAEWEPDFGPSCFVPSWGATVTGARKFLIAFNINLLST
KEQAHRIALNLREQGRGQHQPGRLRKVQGIGWYLEEKNLAQVSTNLLDFEVTGLHTVFEETCRE
AQELRLPVVGSQLVGLVPLKALLDAAAFYCDKENLFVLEEEQRIRLVVSRLGLDSLAPFNPSER
VIEYLVPDRLEKSLLDMSLRAFLREVGARSATPGGGSVAAASAAMGAALASMVGQMTYGRRQFE
QLDAVMRRLIPPFHAALAQLTSLVDADAQAFATYLEAMKLPKNTPEDRDRRTAALQEGLRGAVA
VPLALAETVSPLWPALRELALCGNLACQSDLQVAAKALEMGVFGAYFNVLINLKDVKDEVFKDQ
VRQRAASLLQEAKAQAALVLESLEARQE

hide sequence

RefSeq Acc Id:

ENSSTOP00000023738 ⟸ ENSSTOT00000022402

Protein Domains

Formiminotransferase C-terminal subdomain Formiminotransferase N-terminal subdomain

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000020132	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000022402.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.120.680	UniProtKB/TrEMBL
	3.30.70.670	UniProtKB/TrEMBL
	3.30.990.10	UniProtKB/TrEMBL
InterPro	Cyclodeamin/CycHdrlase	UniProtKB/TrEMBL
	Formiminotransferase_C	UniProtKB/TrEMBL
	Formiminotransferase_C_sf	UniProtKB/TrEMBL
	Formiminotransferase_cat	UniProtKB/TrEMBL
	Formiminotransferase_N	UniProtKB/TrEMBL
	Formiminotransferase_N_sf	UniProtKB/TrEMBL
	FormiminoTrfase_cat_dom_sf	UniProtKB/TrEMBL
	Formintransfe-cycloase-like_sf	UniProtKB/TrEMBL
NCBI Gene	Ftcd	ENTREZGENE
PANTHER	FORMIMIDOYLTRANSFERASE-CYCLODEAMINASE	UniProtKB/TrEMBL
	FORMIMINOTRANSFERASE-CYCLODEAMINASE	UniProtKB/TrEMBL
Pfam	FTCD	UniProtKB/TrEMBL
	FTCD_C	UniProtKB/TrEMBL
	FTCD_N	UniProtKB/TrEMBL
SMART	FTCD	UniProtKB/TrEMBL
	FTCD_N	UniProtKB/TrEMBL
Superfamily-SCOP	SSF101262	UniProtKB/TrEMBL
	SSF55116	UniProtKB/TrEMBL
UniProt	I3NH91	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB