Vps35 (VPS35 retromer complex component) - Rat Genome Database
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Gene: Vps35 (VPS35 retromer complex component) Ictidomys tridecemlineatus
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Symbol: Vps35
Name: VPS35 retromer complex component
RGD ID: 12504821
Description: ENCODES a protein that exhibits D1 dopamine receptor binding (ortholog); INVOLVED IN endocytic recycling (ortholog); lysosome organization (ortholog); mitochondrial fragmentation involved in apoptotic process (ortholog); PARTICIPATES IN altered retromer-mediated pathway; Parkinson's disease pathway; retromer-mediated pathway; ASSOCIATED WITH genetic disease (ortholog); late onset Parkinson's disease (ortholog); Meier-Gorlin syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); early endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: vacuolar protein sorting 35 homolog; vacuolar protein sorting-associated protein 35; VPS35, retromer complex component
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647550,476 - 77,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
endocytic recycling  (ISO)
lysosome organization  (ISO)
mitochondrial fragmentation involved in apoptotic process  (ISO)
mitochondrion to lysosome transport  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cellular protein localization  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of late endosome to lysosome transport  (ISO)
negative regulation of lysosomal protein catabolic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of protein homooligomerization  (ISO)
neurotransmitter receptor transport, endosome to plasma membrane  (ISO)
neurotransmitter receptor transport, endosome to postsynaptic membrane  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cellular protein catabolic process  (ISO)
positive regulation of dopamine biosynthetic process  (ISO)
positive regulation of dopamine receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of locomotion involved in locomotory behavior  (ISO)
positive regulation of mitochondrial fission  (ISO)
positive regulation of Wnt protein secretion  (ISO)
protein destabilization  (ISO)
protein localization to endosome  (ISO)
protein localization to organelle  (ISO)
regulation of cellular protein metabolic process  (ISO)
regulation of dendritic spine maintenance  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of protein stability  (ISO)
regulation of terminal button organization  (ISO)
retrograde transport, endosome to Golgi  (ISO)
synapse assembly  (ISO)
transcytosis  (ISO)
vesicle-mediated transport in synapse  (ISO)
voluntary musculoskeletal movement  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Vps35
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647550,476 - 77,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VPS35
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1646,656,132 - 46,689,518 (-)EnsemblGRCh38hg38GRCh38
GRCh381646,656,132 - 46,689,194 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371646,690,044 - 46,723,090 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371646,693,589 - 46,723,144 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361645,251,090 - 45,280,645 (-)NCBINCBI36hg18NCBI36
Build 341645,251,091 - 45,280,593NCBI
Celera1631,201,751 - 31,231,306 (-)NCBI
Cytogenetic Map16q11.2NCBI
HuRef1632,582,305 - 32,611,908 (-)NCBIHuRef
CHM1_11648,098,826 - 48,130,101 (-)NCBICHM1_1
Vps35
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,987,014 - 86,026,146 (-)NCBIGRCm39mm39
GRCm38885,260,385 - 85,299,517 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,260,392 - 85,299,802 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,784,291 - 87,823,396 (-)NCBIGRCm37mm9NCBIm37
MGSCv36888,150,497 - 88,189,603 (-)NCBImm8
Celera889,541,447 - 89,580,450 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.61NCBI
Vps35
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21921,765,771 - 21,801,620 (+)NCBI
Rnor_6.0 Ensembl1927,464,937 - 27,500,636 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01927,464,937 - 27,500,636 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01938,430,733 - 38,466,263 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41923,124,790 - 23,161,655 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1921,625,446 - 21,661,413 (+)NCBICelera
Cytogenetic Map19q11NCBI
Vps35
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955448204,991 - 240,160 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955448207,582 - 240,264 (-)NCBIChiLan1.0ChiLan1.0
VPS35
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11645,815,716 - 45,846,672 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1645,817,371 - 45,846,531 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01626,924,901 - 26,954,443 (-)NCBIMhudiblu_PPA_v0panPan3
VPS35
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl158,428,172 - 8,454,049 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1158,428,073 - 8,454,601 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
VPS35
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl637,944,127 - 37,986,203 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1637,944,099 - 37,977,091 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
VPS35
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1532,509,037 - 32,539,371 (-)NCBI
ChlSab1.1 Ensembl532,508,580 - 32,539,343 (-)Ensembl
Vps35
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624914160,483 - 188,534 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005318139   ⟹   XP_005318196
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493647550,476 - 77,795 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013366227   ⟹   XP_013221681
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493647550,478 - 77,797 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005318196 (Get FASTA)   NCBI Sequence Viewer  
  XP_013221681 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005318196   ⟸   XM_005318139
- Peptide Label: isoform X1
- UniProtKB: I3M2Y3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013221681   ⟸   XM_013366227
- Peptide Label: isoform X2
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003772 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000003380 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003774 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.660 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Vps35 UniProtKB/TrEMBL
  Vps35_C UniProtKB/TrEMBL
NCBI Gene Vps35 ENTREZGENE
PANTHER PTHR11099 UniProtKB/TrEMBL
Pfam Vps35 UniProtKB/TrEMBL
PIRSF Retromer_Vps35 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt I3M2Y3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Vps35  VPS35 retromer complex component    VPS35, retromer complex component  Symbol and/or name change 5135510 APPROVED