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Gene: Ap4m1 (adaptor related protein complex 4 subunit mu 1) Ictidomys tridecemlineatus

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Symbol:

Ap4m1

Name:

adaptor related protein complex 4 subunit mu 1

RGD ID:

12502877

Description:

ENCODES a protein that exhibits protein domain specific binding (inferred); INVOLVED IN protein localization to basolateral plasma membrane (ortholog); ASSOCIATED WITH Alazami-Yuan Syndrome (ortholog); Developmental Disabilities (ortholog); genetic disease (ortholog); FOUND IN trans-Golgi network (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

adaptor related protein complex 4 mu 1 subunit; AP-4 complex subunit mu-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	133,784,566 - 133,790,213 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	246,335 - 254,975 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	246,335 - 250,278 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alazami-Yuan Syndrome (ISO)

Developmental Disabilities (ISO)

genetic disease (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 50 (ISO)

intellectual disability (ISO)

microcephaly (ISO)

Nervous System Malformations (ISO)

paraplegia (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome assembly (IEA)

Golgi to endosome transport (IEA)

Golgi to lysosome transport (IEA)

intracellular protein transport (IEA)

protein localization (IEA)

protein localization to basolateral plasma membrane (ISO)

protein targeting (IEA)

protein targeting to lysosome (IEA)

protein transport (IEA)

vesicle-mediated transport (IEA)

Cellular Component

AP-4 adaptor complex (IEA)

clathrin adaptor complex (IEA)

cytosol (IEA)

early endosome (IEA)

endomembrane system (IEA)

endosome (IEA)

Golgi apparatus (IEA)

membrane (IEA)

trans-Golgi network (IEA,ISO)

Molecular Function

protein binding (ISO)

protein domain specific binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ap4m1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	133,784,566 - 133,790,213 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	246,335 - 254,975 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	246,335 - 250,278 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AP4M1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	100,100,794 - 100,109,039 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	100,100,858 - 100,110,345 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	99,699,266 - 99,706,662 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	99,537,066 - 99,542,739 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	99,343,830 - 99,349,453	NCBI
Celera	7	94,433,789 - 94,439,462 (+)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	94,334,781 - 94,340,455 (+)	NCBI		HuRef
CHM1_1	7	99,629,287 - 99,634,960 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	101,340,729 - 101,348,885 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	99,059,249 - 99,064,921 (+)	NCBI

Ap4m1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	138,170,283 - 138,178,691 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	138,170,264 - 138,178,691 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	138,172,021 - 138,180,429 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	138,172,002 - 138,180,429 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	138,613,249 - 138,619,915 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	138,401,809 - 138,408,471 (+)	NCBI		MGSCv36	mm8
Celera	5	135,151,353 - 135,157,995 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	76.98	NCBI

Ap4m1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	22,163,474 - 22,171,734 (+)	NCBI		GRCr8
mRatBN7.2	12	17,049,766 - 17,055,954 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	17,049,777 - 17,058,026 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	17,873,224 - 17,879,102 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	18,496,968 - 18,502,846 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	17,550,374 - 17,556,252 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	19,314,222 - 19,320,339 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	19,314,251 - 19,320,142 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	21,371,852 - 21,377,968 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	17,614,882 - 17,620,773 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	17,604,001 - 17,610,295 (+)	NCBI
Celera	12	18,980,013 - 18,985,904 (+)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

Ap4m1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955573	759,222 - 763,222 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955573	759,222 - 763,222 (-)	NCBI	ChiLan1.0	ChiLan1.0

AP4M1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	118,020,512 - 118,028,432 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	166,285,144 - 166,293,064 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	92,137,085 - 92,142,756 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	105,570,205 - 105,575,971 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	105,570,205 - 105,575,971 (+)	Ensembl	panpan1.1		panPan2

AP4M1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	9,488,496 - 9,492,703 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	9,486,372 - 9,492,243 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	6	9,425,495 - 9,429,591 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	9,423,773 - 9,429,399 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	9,274,807 - 9,278,909 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	9,255,130 - 9,259,226 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	9,434,718 - 9,438,823 (-)	NCBI		UU_Cfam_GSD_1.0

AP4M1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	8,013,747 - 8,017,700 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	8,013,701 - 8,017,701 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

AP4M1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	12,971,007 - 12,976,914 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	12,971,297 - 12,976,779 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	3,296,018 - 3,301,894 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ap4m1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	16,883,828 - 16,887,685 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	16,883,725 - 16,887,678 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005328438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000009045 ⟹ ENSSTOP00000008107

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936543	246,335 - 254,975 (+)	Ensembl

RefSeq Acc Id:

XM_005328438 ⟹ XP_005328495

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	133,784,566 - 133,790,213 (-)	NCBI
SpeTri2.0	NW_004936543	246,335 - 250,278 (+)	NCBI

Sequence:

show sequence

ACGGGGAGGTGGTGGGCGGTGTGGGGACTCGCCCAGCTGGGAGGGACTGGCGCCGGGTTTCCCG
CGGCCCGAGCTGATGAGGGAGGAGGGGAGTCATTCTTAAAGGGCCAGCCCGTGCGCGTTCTTTT
GTTCCGGGGCAGCAGGGCGGGGCAGGCCCAACTTTCTTCGTCTTCTGGTTTTCTTTTCCGAACG
GCCATGATTTCCCAGTTCTTCATCCTGTCTTCCAAGGGGGACCCTCTCATCTACAAAGACTTCC
GCGGGGACAGTGGTGGCCGAGATGTGGCTGAGCTCTTCTACCGGAAGCTGACGGGACTGCCTGG
AGACGAGTCCCCGGTTGTCATGCACCACGATGACCGACATTTCATTCACATCAGACACAGCAGC
CTCTATTTGGTGGCCACCACTTCTGAAAACATTTCTCCCTTCAGCCTCCTAGAGCTGCTGTCCC
GGTTAGCCACTCTCTTGGGGGACTACTGTGGCTCCCTCAGCGAGGGGACCATCTCTCGCAATGT
GGCTCTTGTCTATGAAATCCTGGATGAAGTGCTGGACTATGGTTATGTTCAGACAACGTCCACA
GAGATGCTGAGGAACTTCATCCAGACAGAAGCCGTGGTCAGCAAGCCCTTCAGTCTGTTTGACC
TCAGCAGTGTTGGCTTGTTTGGGGCTGAGACACAACAGAGCAAAGTGGCCCCTAGCAGTGCAGC
CAGTCGCCCTGTCTTGTCCAGTCGCTCTGATCAGAGCCAGAAGAATGAAGTTTTTTTAGATGTG
GTTGAGAGATTGTCTGTACTGATAGCATCTAATGGCTCACTGTTGAAGGTGGATGTGCAGGGAG
AGATCCGGTTGAAGAGCTTCCTTCCCAGCGGCTCTGAGATGCGCATTGGCTTGACAGAAGAATT
TTGTGTGGGGAAGTCAGAACTCAGAGGGTACGGGCCAGGAATTCGGGTTGATGAGGTTTCATTT
CACAGCTCAGTAAATCTGGATGAGTTTGAGTCTCATCGGATCCTTCGCTTGCAGCCACCCCAGG
GTGAGCTGACTGTGATGAGGTACCAACTCTCCGATGACCTCCCCTCCCCGCTTCCCTTTCGGCT
CTTTCCCTCTGTGCAGTGGGACCGAGGCTCAGGCCGGCTCCAGGTTTACCTGAAGTTACGGTGT
GATCTGCCCCCAAAGAGCCAAGCTCTTAATGTCCGACTGCACCTTCCTCTGCCACGAGGGGTGG
TCAGCCTGTCTCAGGAGCTGAGCAGTCCAGAGCAGAAGGCAGAGCTGGGGGAAGGAGCCCTTCG
CTGGGACCTGCCCCGGGTACAGGGAGGCTCTCAACTCTCAGGCCTTTTCCAGATGGACGTTCCA
GGCCTGCCAGGGCCTCCCAGCCACGGGCCCTCCACCTCAGCTCCTCCGCTGGGGCTGGGCCCTG
CAAGCCTCTCCTTTGAACTCCCCCGGCATACGTGCTCTGGCCTCCAGGTTCGCTTCCTCAGGCT
GTCCTTCAGGCCTTGCAGCAATGCCAACCCCCACAAGTGGGTACGCCACCTAAGCCACAGTGAT
GCCTATGTCATTCGGATCTGAGGCTCCCCAAGTACAGACACAGGCGGCAAAGGCAACAAGCGGT
CAAGAAGAGGACGATATTTTCTTTCTTGGCATCTTGGCCTATGGCCCTAAATTTGAGCAGGAAG
AATCTTGAGGCCAGGAGGCCTCAATGGATTCACCCTTCCATGGTATCTGGCAGAAGAAGGCTCA
GGACTTACAAATCAAACTTTTATTCTGAGGAACTGACTGTACAGTATCTAAAAAGAAAGTCATG
TGGGAGAAGCAGCCTACTACTTCTTCCAGCCAGCGTGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005328495	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008107.2
GenBank Protein	KAG3259933	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005328495 ⟸ XM_005328438

- UniProtKB:

I3MCU4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHDDRHFIHIRHSSL
YLVATTSENISPFSLLELLSRLATLLGDYCGSLSEGTISRNVALVYEILDEVLDYGYVQTTSTE
MLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVV
ERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFH
SSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCD
LPPKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELGEGALRWDLPRVQGGSQLSGLFQMDVPG
LPGPPSHGPSTSAPPLGLGPASLSFELPRHTCSGLQVRFLRLSFRPCSNANPHKWVRHLSHSDA
YVIRI

hide sequence

Ensembl Acc Id:

ENSSTOP00000008107 ⟸ ENSSTOT00000009045

Protein Domains

MHD

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009043	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009045.3	UniProtKB/TrEMBL
Gene3D-CATH	3.30.450.60	UniProtKB/TrEMBL
	Mu homology domain, subdomain B	UniProtKB/TrEMBL
InterPro	Adaptor_comp_med_subunit	UniProtKB/TrEMBL
	AP2_Mu_C_sf	UniProtKB/TrEMBL
	AP_mu_sigma_su	UniProtKB/TrEMBL
	Clathrin_mu	UniProtKB/TrEMBL
	Clathrin_mu_CS	UniProtKB/TrEMBL
	Longin-like_dom_sf	UniProtKB/TrEMBL
	MHD	UniProtKB/TrEMBL
NCBI Gene	Ap4m1	ENTREZGENE
PANTHER	AP COMPLEX SUBUNIT MU	UniProtKB/TrEMBL
Pfam	Adap_comp_sub	UniProtKB/TrEMBL
	Clat_adaptor_s	UniProtKB/TrEMBL
PIRSF	Clathrin_mu	UniProtKB/TrEMBL
PRINTS	CLATHRINADPT	UniProtKB/TrEMBL
PROSITE	CLAT_ADAPTOR_M_2	UniProtKB/TrEMBL
	MHD	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49447	UniProtKB/TrEMBL
	SSF64356	UniProtKB/TrEMBL
UniProt	I3MCU4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-01	Ap4m1	adaptor related protein complex 4 subunit mu 1		adaptor related protein complex 4 mu 1 subunit	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM