LOC101977053 (IST1 factor associated with ESCRT-III) - Rat Genome Database

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Gene: LOC101977053 (IST1 factor associated with ESCRT-III) Ictidomys tridecemlineatus
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Symbol: LOC101977053 (Ensembl: IST1)
Name: IST1 factor associated with ESCRT-III
RGD ID: 12502394
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN collateral sprouting (ortholog); positive regulation of collateral sprouting (ortholog); ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); genetic disease (ortholog); FOUND IN extracellular exosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ist1; IST1 homolog; IST1, ESCRT-III associated factor; IST1, ESCRT-III associated factor, transcript variant X1; IST1, ESCRT-III associated factor, transcript variant X2; IST1, ESCRT-III associated factor, transcript variant X3; IST1, ESCRT-III associated factor, transcript variant X4; IST1, ESCRT-III associated factor, transcript variant X5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,680,804 - 37,699,103 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647521,890,013 - 21,908,245 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647521,890,011 - 21,908,256 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC101977053
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,680,804 - 37,699,103 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647521,890,013 - 21,908,245 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647521,890,011 - 21,908,256 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381671,894,408 - 71,931,199 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1671,845,996 - 71,931,199 (+)EnsemblGRCh38hg38GRCh38
GRCh371671,928,311 - 71,965,102 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,486,947 - 70,520,407 (+)NCBINCBI36Build 36hg18NCBI36
Celera1656,243,371 - 56,276,822 (+)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,696,177 - 57,731,724 (+)NCBIHuRef
CHM1_11673,341,627 - 73,377,874 (+)NCBICHM1_1
T2T-CHM13v2.01677,711,542 - 77,748,323 (+)NCBIT2T-CHM13v2.0
Ist1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,397,953 - 110,419,929 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,397,957 - 110,419,892 (-)EnsemblGRCm39 Ensembl
GRCm388109,671,321 - 109,693,297 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,671,325 - 109,693,260 (-)EnsemblGRCm38mm10GRCm38
MGSCv378112,195,221 - 112,217,194 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368112,560,458 - 112,582,393 (-)NCBIMGSCv36mm8
Celera8113,896,960 - 113,918,958 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.18NCBI
Ist1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,558,353 - 54,580,551 (-)NCBIGRCr8
mRatBN7.21937,648,840 - 37,671,019 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,648,095 - 37,670,956 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,461,787 - 44,483,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,115,119 - 45,137,228 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,424,730 - 47,446,839 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,968,692 - 41,990,843 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,968,705 - 41,990,843 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,793,716 - 52,815,862 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,554,205 - 39,576,343 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11939,559,093 - 39,581,181 (-)NCBI
Celera1937,052,746 - 37,074,884 (-)NCBICelera
Cytogenetic Map19q12NCBI
Ist1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,589,311 - 4,630,203 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554844,589,311 - 4,630,464 (+)NCBIChiLan1.0ChiLan1.0
IST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21882,231,091 - 82,313,273 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11688,158,887 - 88,202,426 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01653,082,530 - 53,115,965 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11671,733,868 - 71,765,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,733,302 - 71,765,969 (+)Ensemblpanpan1.1panPan2
IST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,660,033 - 77,693,831 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,660,081 - 77,692,396 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha577,621,109 - 77,655,606 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0578,099,321 - 78,133,852 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,098,618 - 78,133,639 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1577,919,418 - 77,953,932 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,742,127 - 77,776,623 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0578,241,426 - 78,275,957 (+)NCBIUU_Cfam_GSD_1.0
IST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,836,752 - 14,911,311 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1614,868,859 - 14,910,679 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,465,663 - 14,489,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,030,916 - 55,063,824 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl555,050,795 - 55,064,549 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604717,832,602 - 17,864,267 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000001022   ⟹   ENSSTOP00000000917
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647521,890,013 - 21,908,245 (-)Ensembl
RefSeq Acc Id: XM_005318388   ⟹   XP_005318445
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934937,680,804 - 37,699,103 (+)NCBI
SpeTri2.0NW_00493647521,890,011 - 21,908,256 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013366386   ⟹   XP_013221840
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934937,687,210 - 37,699,103 (+)NCBI
SpeTri2.0NW_00493647521,890,011 - 21,901,904 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021721713   ⟹   XP_021577388
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934937,685,399 - 37,699,103 (+)NCBI
SpeTri2.0NW_00493647521,890,011 - 21,903,408 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040279145   ⟹   XP_040135079
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934937,680,867 - 37,699,103 (+)NCBI
RefSeq Acc Id: XM_040279146   ⟹   XP_040135080
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934937,680,869 - 37,699,103 (+)NCBI
RefSeq Acc Id: XM_040279147   ⟹   XP_040135081
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934937,680,804 - 37,699,103 (+)NCBI
RefSeq Acc Id: XM_040279148   ⟹   XP_040135082
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934937,685,399 - 37,699,103 (+)NCBI
RefSeq Acc Id: XM_040279149   ⟹   XP_040135083
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934937,680,866 - 37,699,103 (+)NCBI
RefSeq Acc Id: XM_040279150   ⟹   XP_040135084
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934937,680,865 - 37,699,103 (+)NCBI
RefSeq Acc Id: XM_040279151   ⟹   XP_040135085
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934937,680,866 - 37,699,103 (+)NCBI
RefSeq Acc Id: XM_040279152   ⟹   XP_040135086
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934937,687,210 - 37,699,103 (+)NCBI
RefSeq Acc Id: XP_005318445   ⟸   XM_005318388
- Peptide Label: isoform X5
- UniProtKB: I3LXT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013221840   ⟸   XM_013366386
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_021577388   ⟸   XM_021721713
- Peptide Label: isoform X5
- UniProtKB: I3LXT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040135081   ⟸   XM_040279147
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040135084   ⟸   XM_040279150
- Peptide Label: isoform X6
RefSeq Acc Id: XP_040135083   ⟸   XM_040279149
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040135085   ⟸   XM_040279151
- Peptide Label: isoform X7
RefSeq Acc Id: XP_040135079   ⟸   XM_040279145
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040135080   ⟸   XM_040279146
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040135082   ⟸   XM_040279148
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040135086   ⟸   XM_040279152
- Peptide Label: isoform X8
RefSeq Acc Id: ENSSTOP00000000917   ⟸   ENSSTOT00000001022


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001021 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001022.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.60 UniProtKB/TrEMBL
InterPro Ist1 UniProtKB/TrEMBL
  IST1-like UniProtKB/TrEMBL
NCBI Gene Ist1 ENTREZGENE
PANTHER IST1 HOMOLOG UniProtKB/TrEMBL
  PTHR12161 UniProtKB/TrEMBL
Pfam Ist1 UniProtKB/TrEMBL
UniProt I3LXT8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 LOC101977053  IST1 factor associated with ESCRT-III  Ist1  IST1 factor associated with ESCRT-III  Symbol and/or name change 5135510 APPROVED
2019-02-05 Ist1  IST1 factor associated with ESCRT-III    IST1, ESCRT-III associated factor  Symbol and/or name change 5135510 APPROVED