Prps2 (phosphoribosyl pyrophosphate synthetase 2) - Rat Genome Database

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Gene: Prps2 (phosphoribosyl pyrophosphate synthetase 2) Ictidomys tridecemlineatus
Analyze
Symbol: Prps2
Name: phosphoribosyl pyrophosphate synthetase 2
RGD ID: 12498898
Description: ENCODES a protein that exhibits ADP binding (ortholog); AMP binding (ortholog); ATP binding (ortholog); INVOLVED IN 5-phosphoribose 1-diphosphate biosynthetic process (ortholog); AMP biosynthetic process (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN de novo purine biosynthetic pathway; ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytosol (ortholog); protein-containing complex (ortholog); ribose phosphate diphosphokinase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ribose-phosphate pyrophosphokinase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X2,547,014 - 2,576,951 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364702,546,985 - 2,576,953 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364702,547,038 - 2,576,951 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Prps2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X2,547,014 - 2,576,951 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364702,546,985 - 2,576,953 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364702,547,038 - 2,576,951 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRPS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X12,791,412 - 12,824,222 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX12,791,355 - 12,824,222 (+)EnsemblGRCh38hg38GRCh38
GRCh37X12,809,531 - 12,842,341 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X12,719,414 - 12,752,264 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X12,569,187 - 12,601,996NCBI
CeleraX16,923,480 - 16,956,355 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX10,576,287 - 10,608,838 (+)NCBIHuRef
CHM1_1X12,839,890 - 12,872,768 (+)NCBICHM1_1
T2T-CHM13v2.0X12,372,896 - 12,405,716 (+)NCBIT2T-CHM13v2.0
Prps2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X166,129,316 - 166,165,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX166,129,318 - 166,165,745 (-)EnsemblGRCm39 Ensembl
GRCm38X167,346,320 - 167,382,872 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX167,346,322 - 167,382,749 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X163,784,265 - 163,820,631 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X162,690,438 - 162,726,804 (-)NCBIMGSCv36mm8
CeleraX150,519,899 - 150,556,214 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX78.32NCBI
Prps2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X30,592,845 - 30,630,127 (+)NCBIGRCr8
mRatBN7.2X26,975,915 - 27,013,184 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX26,976,061 - 27,013,181 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX28,044,842 - 28,082,133 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X31,451,654 - 31,486,764 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X27,662,446 - 27,699,733 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X28,435,275 - 28,472,882 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX28,435,507 - 28,472,880 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X28,831,387 - 28,868,992 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X47,274,362 - 47,315,274 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X47,327,830 - 47,368,743 (+)NCBI
CeleraX27,388,118 - 27,424,061 (+)NCBICelera
Cytogenetic MapXq13NCBI
Prps2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955544478,954 - 512,614 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955544480,587 - 512,019 (-)NCBIChiLan1.0ChiLan1.0
PRPS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X14,575,640 - 14,608,923 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X14,579,306 - 14,612,589 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X5,403,465 - 5,436,751 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X12,693,286 - 12,726,355 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX12,693,286 - 12,726,355 (+)Ensemblpanpan1.1panPan2
PRPS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X9,281,686 - 9,326,551 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX9,281,730 - 9,418,289 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX9,237,918 - 9,283,251 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X9,233,376 - 9,278,743 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX9,233,390 - 9,275,394 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X9,217,987 - 9,263,321 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X9,257,264 - 9,302,594 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X9,249,560 - 9,294,897 (+)NCBIUU_Cfam_GSD_1.0
PRPS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX9,503,953 - 9,530,086 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X9,505,034 - 9,531,044 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X10,404,804 - 10,432,367 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRPS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X11,282,248 - 11,316,214 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX11,282,389 - 11,316,423 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605613,074,038 - 13,107,909 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prps2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248821,456,572 - 1,489,605 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248821,456,885 - 1,489,489 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005315967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000006057   ⟹   ENSSTOP00000005419
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364702,546,985 - 2,576,953 (+)Ensembl
RefSeq Acc Id: XM_005315967   ⟹   XP_005316024
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X2,547,014 - 2,576,951 (+)NCBI
SpeTri2.0NW_0049364702,547,038 - 2,576,951 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005316024 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000005419.2
Reference Protein Sequences
RefSeq Acc Id: XP_005316024   ⟸   XM_005315967
- UniProtKB: I3M773 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000005419   ⟸   ENSSTOT00000006057
Protein Domains
Ribose-phosphate pyrophosphokinase N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000006056 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000006057.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2020 UniProtKB/TrEMBL
InterPro PRib_PP_synth_CS UniProtKB/TrEMBL
  Pribosyltran_N UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/TrEMBL
  PRTase-like UniProtKB/TrEMBL
  Rib-P_diPkinase UniProtKB/TrEMBL
  Rib-P_diPkinase_bac UniProtKB/TrEMBL
NCBI Gene Prps2 ENTREZGENE
PANTHER PTHR10210 UniProtKB/TrEMBL
  RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2 UniProtKB/TrEMBL
Pfam Pribosyl_synth UniProtKB/TrEMBL
  Pribosyltran_N UniProtKB/TrEMBL
PROSITE PRPP_SYNTHASE UniProtKB/TrEMBL
SMART Pribosyltran_N UniProtKB/TrEMBL
Superfamily-SCOP SSF53271 UniProtKB/TrEMBL
UniProt I3M773 ENTREZGENE, UniProtKB/TrEMBL