Ralgds (ral guanine nucleotide dissociation stimulator) - Rat Genome Database

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Gene: Ralgds (ral guanine nucleotide dissociation stimulator) Ictidomys tridecemlineatus
Analyze
Symbol: Ralgds
Name: ral guanine nucleotide dissociation stimulator
RGD ID: 12496064
Description: ENCODES a protein that exhibits GTPase regulator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN Ras protein signal transduction (inferred); signal transduction (inferred); small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); Ehlers-Danlos syndrome classic type 1 (ortholog); genetic disease (ortholog); FOUND IN brush border (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,706,834 - 199,732,858 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648719,476,205 - 19,495,105 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648719,475,361 - 19,501,347 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
brush border  (IEA)
cytosol  (IEA)
nucleus  (IEA)
plasma membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ralgds
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,706,834 - 199,732,858 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648719,476,205 - 19,495,105 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648719,475,361 - 19,501,347 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RALGDS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,097,722 - 133,149,210 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,097,720 - 133,149,334 (-)EnsemblGRCh38hg38GRCh38
GRCh379135,973,109 - 136,024,597 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369134,962,928 - 135,014,409 (-)NCBINCBI36Build 36hg18NCBI36
Build 349133,002,661 - 133,026,115NCBI
Celera9106,514,832 - 106,566,263 (-)NCBICelera
Cytogenetic Map9q34.13-q34.2NCBI
HuRef9105,466,726 - 105,500,074 (-)NCBIHuRef
CHM1_19136,123,741 - 136,174,957 (-)NCBICHM1_1
T2T-CHM13v2.09145,311,872 - 145,363,296 (-)NCBIT2T-CHM13v2.0
Ralgds
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39228,403,037 - 28,443,085 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl228,403,137 - 28,443,093 (+)EnsemblGRCm39 Ensembl
GRCm38228,513,089 - 28,553,082 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl228,513,125 - 28,553,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv37228,368,687 - 28,408,602 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36228,335,340 - 28,375,079 (+)NCBIMGSCv36mm8
Celera228,217,341 - 28,257,258 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.38NCBI
Ralgds
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,237,644 - 32,278,045 (+)NCBIGRCr8
mRatBN7.2311,839,686 - 11,880,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl311,839,416 - 11,880,059 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx314,931,722 - 14,952,349 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0323,516,673 - 23,537,304 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0321,771,127 - 21,791,756 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.037,090,134 - 7,130,548 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,109,920 - 7,130,548 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0312,440,157 - 12,481,565 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.437,516,054 - 7,537,651 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.137,516,353 - 7,537,935 (+)NCBI
Celera36,640,808 - 6,660,733 (+)NCBICelera
Cytogenetic Map3p12NCBI
Ralgds
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,386,293 - 2,405,161 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,386,293 - 2,405,161 (-)NCBIChiLan1.0ChiLan1.0
RALGDS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2116,207,048 - 6,258,030 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan196,209,384 - 6,260,367 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,218,338 - 104,269,322 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19132,832,924 - 132,847,200 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9132,832,924 - 132,865,901 (-)Ensemblpanpan1.1panPan2
RALGDS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1951,287,252 - 51,329,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha950,550,610 - 50,592,293 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0952,180,564 - 52,222,391 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl952,180,324 - 52,223,270 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1950,980,284 - 51,000,916 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0951,283,824 - 51,325,521 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0951,363,054 - 51,404,763 (+)NCBIUU_Cfam_GSD_1.0
RALGDS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1272,776,846 - 272,824,184 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11272,776,844 - 272,824,179 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21306,700,576 - 306,713,801 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RALGDS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,993,357 - 5,042,347 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl125,018,872 - 5,041,602 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607910,611,288 - 10,660,534 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ralgds
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247603,338,424 - 3,376,864 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247603,338,398 - 3,376,631 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021723687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000010897   ⟹   ENSSTOP00000009773
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648719,476,205 - 19,495,105 (-)Ensembl
RefSeq Acc Id: XM_021723687   ⟹   XP_021579362
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,706,834 - 199,732,858 (-)NCBI
SpeTri2.0NW_00493648719,475,361 - 19,501,347 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_021579362 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000009773.3
GenBank Protein KAG3288258 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021579362   ⟸   XM_021723687
- UniProtKB: I3MGB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000009773   ⟸   ENSSTOT00000010897
Protein Domains
N-terminal Ras-GEF   Ras-associating   Ras-GEF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000010884 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000010897.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro RA_dom UniProtKB/TrEMBL
  RalGDS UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Ralgds ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  PTHR23113:SF35 UniProtKB/TrEMBL
Pfam PF00788 UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PROSITE PS50200 UniProtKB/TrEMBL
  RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
  SM00314 UniProtKB/TrEMBL
Superfamily-SCOP SSF48366 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt I3MGB2 ENTREZGENE, UniProtKB/TrEMBL