Commd1 (copper metabolism domain containing 1)

Gene: Commd1 (copper metabolism domain containing 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Commd1

Name:

copper metabolism domain containing 1

RGD ID:

12494358

Description:

ENCODES a protein that exhibits copper ion binding (inferred); identical protein binding (inferred); phosphatidic acid binding (inferred); INVOLVED IN cholesterol homeostasis (ortholog); low-density lipoprotein particle clearance (ortholog); negative regulation of hypoxia-inducible factor-1alpha signaling pathway (ortholog); ASSOCIATED WITH allergic disease (ortholog); Chronic Hepatitis (ortholog); Copper-Overload Cirrhosis (ortholog); FOUND IN Cul2-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

COMM domain-containing protein 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	21,150,249 - 21,324,134 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	7,247,140 - 7,420,921 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	7,247,160 - 7,421,039 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic disease (ISO)

Chronic Hepatitis (ISO)

Copper-Overload Cirrhosis (ISO)

Dog Diseases (ISO)

genetic disease (ISO)

liver cirrhosis (ISO)

schizophrenia (ISO)

Wilson disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cholesterol homeostasis (ISO)

copper ion homeostasis (IEA)

Golgi to plasma membrane transport (IEA)

low-density lipoprotein particle clearance (ISO)

negative regulation of hypoxia-inducible factor-1alpha signaling pathway (ISO)

negative regulation of protein localization to cell surface (IEA)

negative regulation of sodium ion transmembrane transport (IEA)

nucleotide-excision repair (IEA)

plasma membrane to endosome transport (IEA)

positive regulation of cholesterol import (ISO)

positive regulation of endosome to plasma membrane protein transport (ISO)

positive regulation of protein localization to cell surface (ISO)

positive regulation of protein ubiquitination (IEA)

protein destabilization (ISO)

protein localization to cell surface (ISO)

regulation of plasma lipoprotein particle levels (ISO)

regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA)

Cellular Component

Cul2-RING ubiquitin ligase complex (IEA)

cytoplasm (IEA)

cytosol (IEA)

early endosome (IEA)

endosome (IEA)

nucleoplasm (IEA)

nucleus (IEA)

recycling endosome (IEA)

Molecular Function

copper ion binding (IEA)

identical protein binding (IEA)

phosphatidic acid binding (IEA)

phosphatidylinositol-3,4,5-trisphosphate binding (IEA)

phosphatidylinositol-3,4-bisphosphate binding (IEA)

phosphatidylinositol-3,5-bisphosphate binding (IEA)

phosphatidylinositol-4,5-bisphosphate binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

sodium channel inhibitor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Commd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	21,150,249 - 21,324,134 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	7,247,140 - 7,420,921 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	7,247,160 - 7,421,039 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COMMD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	61,888,391 - 62,136,058 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	61,888,724 - 62,147,247 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	62,115,526 - 62,363,193 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	61,986,307 - 62,216,709 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	62,044,453 - 62,274,855	NCBI
Celera	2	61,977,700 - 62,207,946 (+)	NCBI		Celera
Cytogenetic Map	2	p15	NCBI
HuRef	2	61,871,871 - 62,101,672 (+)	NCBI		HuRef
CHM1_1	2	62,062,726 - 62,293,462 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	61,894,549 - 62,142,285 (+)	NCBI		T2T-CHM13v2.0

Commd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	22,849,728 - 22,934,539 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	22,846,136 - 22,932,382 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	22,899,728 - 22,984,539 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	22,896,136 - 22,982,382 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	22,799,728 - 22,882,284 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	22,799,728 - 22,882,284 (-)	NCBI		MGSCv36	mm8
Celera	11	25,035,441 - 25,117,915 (-)	NCBI		Celera
Cytogenetic Map	11	A3.2	NCBI
cM Map	11	14.22	NCBI

Commd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	101,081,667 - 101,185,738 (-)	NCBI		GRCr8
mRatBN7.2	14	96,880,463 - 96,984,494 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	96,880,463 - 96,984,501 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	101,219,806 - 101,317,674 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	102,462,099 - 102,559,973 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	98,933,706 - 99,031,576 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	107,664,321 - 107,759,974 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	107,664,255 - 107,760,191 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	107,724,470 - 107,726,728 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	14	107,804,733 - 107,835,993 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	103,571,472 - 103,667,692 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	95,868,544 - 95,965,715 (-)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

Commd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	21,927,079 - 22,050,371 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	21,962,837 - 22,067,745 (-)	NCBI	ChiLan1.0	ChiLan1.0

COMMD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	64,248,377 - 64,495,641 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	64,252,327 - 64,499,591 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	61,970,830 - 62,216,677 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	63,121,490 - 63,349,256 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	63,121,521 - 63,349,131 (+)	Ensembl	panpan1.1		panPan2

COMMD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	61,886,281 - 62,059,610 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	61,886,281 - 62,059,591 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	61,775,492 - 61,947,762 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	62,894,268 - 63,067,243 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	62,882,955 - 63,068,508 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	62,578,128 - 62,750,820 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	62,882,129 - 63,053,837 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	63,177,646 - 63,350,655 (+)	NCBI		UU_Cfam_GSD_1.0
Dog Cytomap	10	q26	NCBI

COMMD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	79,770,463 - 79,913,975 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	79,770,315 - 79,913,969 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	83,605,344 - 83,748,646 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

COMMD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	44,839,460 - 45,068,764 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	44,839,542 - 45,068,586 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	66,766,475 - 66,997,250 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Commd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624762	11,302,730 - 11,407,074 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005322051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021724297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040271269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010001352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000015063 ⟹ ENSSTOP00000013499

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936491	7,247,140 - 7,420,921 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000032612 ⟹ ENSSTOP00000024020

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936491	7,247,191 - 7,420,921 (+)	Ensembl

RefSeq Acc Id:

XM_005322051 ⟹ XP_005322108

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024406292	21,150,249 - 21,324,131 (-)	NCBI
SpeTri2.0	NW_004936491	7,247,160 - 7,421,039 (+)	NCBI

Sequence:

show sequence

TGTTTGGGGGGCGGGGCTTTTGCAGACCATGGCGGGCGAGCTTGAGGGATGCAAGTCTCTGAGC
GGGCTGCTGAGCGGCCTGGCCCAGGACGCTTTCCACGGGCACCGGGGCATCACGGAGGAGCTGC
TGAGGAGCCAACTGTATCCGGAGGTGTCGGCTGAGGAGTTCCGTCCCTTTTTGGCGAAGATGAG
GGGGATTCTTAAGTCGATTGCATCTGCAGACATGGATTTCAACCAACTGGAGGCATTTTTGACT
GCTCAAACCAAAAAGCAAGGTGGGATAACATCTGACCAGGCTGCTGTCATTTCCAAATTCTGGA
AGAGCCACAAAACAAAGATTCGAGAGAGCCTCATGAACCAGAGCCGTTGGGACAATGGACTTCG
GGGCCTGAGCTGGAGAGTTGATTCTAAGTCTCAGTCAAGGCACTCATCTCAAATACACACCCCT
GTTGCCATAATAGAGCTAGAATTTGGGAAAAGTGGACAGGAATCTGAATTTCTGTGTTTGGAGT
TTGATGAGATCAAAGTCAACCAAATCTTGAAGAAGCTCTCAGAGGTAGAAGAAACTATCAGCAC
ACTGATGCAACCAGCCTAACTGAAGTTGATGTAGGAAAGACTTGGAGTTATTGAAACAATATTC
ACAATCCTTCCCTACTGACCTTTTTAAAATCTTGTTCCCCTATTGATATTAAATCCTTAAAAGT
CAAATCTTG

hide sequence

RefSeq Acc Id:

XM_021724297 ⟹ XP_021579972

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024406292	21,222,896 - 21,324,134 (-)	NCBI
SpeTri2.0	NW_004936491	7,247,182 - 7,348,947 (+)	NCBI

Sequence:

show sequence

CAGACCATGGCGGGCGAGCTTGAGGGATGCAAGTCTCTGAGCGGGCTGCTGAGCGGCCTGGCCC
AGGACGCTTTCCACGGGCACCGGGGCATCACGGAGGAGCTGCTGAGGAGCCAACTGTATCCGGA
GGTGTCGGCTGAGGAGTTCCGTCCCTTTTTGGCGAAGATGAGGGGGATTCTTAAGTCGATTGCA
TCTGCAGACATGGATTTCAACCAACTGGAGGCATTTTTGACTGCTCAAACCAAAAAGCAAGGTG
GGATAACATCTGACCAGGCTGCTGTCATTTCCAAATTCTGGAAGAGCCACAAAACAAAGATTCG
AGAGAGCCTCATGAACCAGAGCCGTTGGGACAATGGACTTCGGGGCCTGAGCTGGAGAGTTGAT
TCTAAGTCTCAGTCAAGGCACTCATCTCAAATACACACCCCTGTTGCCATAATAGAGCTAGAAT
TTGGGAAAAGTGGACAGAAAATGTATCATCTACAATATGCAGTCTGCCTCAGTTGGATAACTCT
GCAACTTACTCAAAAGAAGTACCTGAGGTCTTCTGTTTTTCCTTACCTACTGTATTGGTTAAGT
TCAGCAACAAGTAACAGAGATCCAAATGAAAGGCTTTAAAAAGGTAGAAGTTTGGGATTGAGGT
GTAGCTCAGTGTTTGACCAGCATGCTCTGGGTTGGAATCCCAGCATGGCAAAAAAAGAAGAAGA
AGAAGAAGAAAAAGTTTATTTGGCTTTTAAATAAAAGTCCAGAGATGGATACTGTTCCATGCAG
TCTTCAGAATACCAGACTTTTCCATCAGATTACTCTATTGTCCCTTGGCTATGATTCTTTGTCC
TCATGGCCCAAGGGTCTATCATATTCATTCCTAAGGCAATGGATGCAGAAGCTACCCATAGGTC
TTACGCTTATATCCCATTGATTAGACTTTAGTCACATGGTCATATATAACTTTAGTGGAGGGAA
GAACATGTTTTTAATCTGGGTGGCTACATGTCCAATTTATTTCTATAGAAAAGGGAATGATGGA
TATTGGAACAGATTGCAGCCTGCCATACTCTGTTTATTATTTCATATGTTGTTTTTGAGTAGAT
AGATTTCAACAGCTTCATGCCAGTTTTAACATAGTGTCTTTAGGATACTATTGATAATAACTTT
TAATACAGACAAAAATCAGGGGAAAAATA

hide sequence

RefSeq Acc Id:

XM_040271269 ⟹ XP_040127203

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024406292	21,150,249 - 21,324,133 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005322108	(Get FASTA)	NCBI Sequence Viewer
	XP_021579972	(Get FASTA)	NCBI Sequence Viewer
	XP_040127203	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000013499.2
	ENSSTOP00000024020.1

RefSeq Acc Id:	XP_005322108 ⟸ XM_005322051
- Peptide Label:	isoform X3
- UniProtKB:	I3MP36 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGELEGCKSLSGLLSGLAQDAFHGHRGITEELLRSQLYPEVSAEEFRPFLAKMRGILKSIASA DMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWDNGLRGLSWRVDSK SQSRHSSQIHTPVAIIELEFGKSGQESEFLCLEFDEIKVNQILKKLSEVEETISTLMQPA hide sequence

RefSeq Acc Id:

XP_021579972 ⟸ XM_021724297

- Peptide Label:

isoform X1

- Sequence:

show sequence

MAGELEGCKSLSGLLSGLAQDAFHGHRGITEELLRSQLYPEVSAEEFRPFLAKMRGILKSIASA
DMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWDNGLRGLSWRVDSK
SQSRHSSQIHTPVAIIELEFGKSGQKMYHLQYAVCLSWITLQLTQKKYLRSSVFPYLLYWLSSA
TSNRDPNERL

hide sequence

RefSeq Acc Id:	XP_040127203 ⟸ XM_040271269
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSSTOP00000024020 ⟸ ENSSTOT00000032612

RefSeq Acc Id:

ENSSTOP00000013499 ⟸ ENSSTOT00000015063

Protein Domains

COMM COMMD1 N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000015062	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000015063.3	UniProtKB/TrEMBL
	ENSSTOT00000032612.1	UniProtKB/TrEMBL
InterPro	COMM	UniProtKB/TrEMBL
	COMMD1_N	UniProtKB/TrEMBL
	Murr1	UniProtKB/TrEMBL
NCBI Gene	Commd1	ENTREZGENE
PANTHER	COMM DOMAIN-CONTAINING PROTEIN 1	UniProtKB/TrEMBL
	PTHR21199	UniProtKB/TrEMBL
Pfam	COMM_domain	UniProtKB/TrEMBL
	COMMD1_N	UniProtKB/TrEMBL
PROSITE	COMM	UniProtKB/TrEMBL
UniProt	A0A287CRS0_ICTTR	UniProtKB/TrEMBL
	I3MP36	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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