Hes5 (hes family bHLH transcription factor 5)

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Gene: Hes5 (hes family bHLH transcription factor 5) Ictidomys tridecemlineatus

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Symbol:

Hes5

Name:

hes family bHLH transcription factor 5

RGD ID:

12491855

Description:

ENCODES a protein that exhibits chromatin binding (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN BMP signaling pathway (ortholog); cell adhesion (ortholog); cell maturation (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Brain Neoplasms (ortholog); chromosome 1p36 deletion syndrome (ortholog); diabetes mellitus (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

hairy and enhancer of split 5; transcription factor HES-5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	28,418,080 - 28,419,331 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936737	1,046,613 - 1,047,950 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936737	1,045,496 - 1,047,865 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain Neoplasms (ISO)

chromosome 1p36 deletion syndrome (ISO)

diabetes mellitus (ISO)

dilated cardiomyopathy 1LL (ISO)

Ehlers-Danlos syndrome spondylodysplastic type 2 (ISO)

Goldberg-Shprintzen syndrome (ISO)

immunodeficiency 16 (ISO)

immunodeficiency 38 (ISO)

Joubert syndrome 25 (ISO)

nervous system disease (ISO)

Neurodevelopmental Disorders (ISO)

Peroxisome Biogenesis Disorder, Complementation Group 7 (ISO)

Shprintzen-Goldberg Craniosynostosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior pattern specification (IEA)

astrocyte differentiation (IEA)

BMP signaling pathway (IEA,ISO)

brain development (IEA)

camera-type eye development (IEA)

cartilage development (IEA)

cell adhesion (IEA,ISO)

cell maturation (IEA,ISO)

central nervous system myelination (IEA,ISO)

chondrocyte differentiation (ISO)

comma-shaped body morphogenesis (IEA)

establishment of epithelial cell polarity (IEA,ISO)

forebrain radial glial cell differentiation (ISO)

glial cell fate commitment (IEA,ISO)

inner ear auditory receptor cell differentiation (IEA,ISO)

inner ear receptor cell stereocilium organization (IEA,ISO)

metanephric nephron tubule morphogenesis (IEA)

negative regulation of astrocyte differentiation (IEA)

negative regulation of DNA-templated transcription (IEA,ISO)

negative regulation of forebrain neuron differentiation (ISO)

negative regulation of inner ear auditory receptor cell differentiation (IEA,ISO)

negative regulation of inner ear receptor cell differentiation (IEA)

negative regulation of neuron differentiation (IEA,ISO)

negative regulation of oligodendrocyte differentiation (IEA,ISO)

negative regulation of pro-B cell differentiation (ISO)

negative regulation of stem cell differentiation (IEA)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

neural tube development (IEA,ISO)

neuron differentiation (IEA,ISO)

neuronal stem cell population maintenance (IEA)

Notch signaling pathway (IEA,ISO)

oligodendrocyte development (IEA,ISO)

oligodendrocyte differentiation (IEA,ISO)

positive regulation of BMP signaling pathway (IEA,ISO)

positive regulation of cell population proliferation (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of Notch signaling pathway (IEA)

positive regulation of receptor signaling pathway via JAK-STAT (IEA)

positive regulation of smooth muscle cell proliferation (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of tyrosine phosphorylation of STAT protein (IEA)

protein-containing complex assembly (IEA)

regulation of cell differentiation (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of epithelial cell proliferation (IEA,ISO)

regulation of myelination (IEA,ISO)

regulation of neurogenesis (IEA,ISO)

regulation of neuron differentiation (IEA,ISO)

regulation of transcription by RNA polymerase II (IEA)

S-shaped body morphogenesis (IEA)

smoothened signaling pathway (IEA,ISO)

specification of loop of Henle identity (IEA)

telencephalon development (IEA,ISO)

Cellular Component

nucleus (IEA)

Molecular Function

chromatin binding (ISO)

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

double-stranded DNA binding (ISO)

protein binding (ISO)

protein dimerization activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Notch signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hes5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	28,418,080 - 28,419,331 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936737	1,046,613 - 1,047,950 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936737	1,045,496 - 1,047,865 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HES5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	2,528,745 - 2,530,263 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	2,528,745 - 2,530,263 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	2,460,184 - 2,461,702 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	2,450,044 - 2,451,544 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	2,492,347 - 2,493,846	NCBI
Celera	1	124,288 - 125,788 (+)	NCBI		Celera
Cytogenetic Map	1	p36.32	NCBI
HuRef	1	1,739,123 - 1,740,623 (-)	NCBI		HuRef
CHM1_1	1	2,446,941 - 2,448,441 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	1,970,389 - 1,971,907 (-)	NCBI		T2T-CHM13v2.0

Hes5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	155,042,358 - 155,046,829 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	155,045,380 - 155,046,828 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	154,960,626 - 154,962,372 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	154,960,923 - 154,962,371 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	154,335,032 - 154,336,480 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	153,804,723 - 153,806,171 (+)	NCBI		MGSCv36	mm8
Celera	4	157,232,968 - 157,234,416 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	86.01	NCBI

Hes5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	170,804,511 - 170,807,988 (+)	NCBI		GRCr8
mRatBN7.2	5	165,522,138 - 165,523,684 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	165,522,234 - 165,523,001 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	168,227,682 - 168,228,449 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	170,049,096 - 170,049,863 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	170,011,628 - 170,012,395 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	172,364,421 - 172,365,188 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	172,364,421 - 172,365,188 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	175,820,392 - 175,821,159 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	171,763,869 - 171,764,636 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	171,774,363 - 171,775,131 (+)	NCBI
Celera	5	163,728,713 - 163,729,480 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Hes5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	8,700,162 - 8,701,748 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	8,700,212 - 8,701,581 (+)	NCBI	ChiLan1.0	ChiLan1.0

HES5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	225,717,334 - 225,719,200 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	224,377,907 - 224,379,810 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	1,261,260 - 1,263,128 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

HES5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	57,387,961 - 57,389,412 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	57,388,674 - 57,389,388 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	5	57,592,177 - 57,593,619 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	57,592,171 - 57,593,605 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	57,583,534 - 57,584,976 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	57,475,854 - 57,477,292 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	57,865,566 - 57,867,005 (-)	NCBI		UU_Cfam_GSD_1.0

HES5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	64,408,956 - 64,410,881 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	64,409,110 - 64,410,541 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

HES5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	129,023,750 - 129,028,790 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	129,027,370 - 129,028,065 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	33,373,940 - 33,375,505 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hes5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	7,516,189 - 7,518,734 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	7,516,279 - 7,517,654 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005339284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000024683 ⟹ ENSSTOP00000021535

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936737	1,046,613 - 1,047,950 (+)	Ensembl

RefSeq Acc Id:

XM_005339284 ⟹ XP_005339341

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	28,418,080 - 28,419,331 (-)	NCBI
SpeTri2.0	NW_004936737	1,045,496 - 1,047,865 (+)	NCBI

Sequence:

show sequence

ATGCAGAACGGCGACTTCCTGGAGATGGTGGGGGCCATGCGCCCTCCTGAGCTCCAGGGTTCTG
CAACTGACTCCTACCACTCCTCCAGGGTGGGAGAGGACCCTGAGGAGCACCTGCTGGCTCCACA
GCAGCCCAAATACCACTTTCTGGGGGCCGCCTGTGCCAGGCTGTATGCACAAACCCTGGCCCAC
CTGAAGCTGCCCAAAGTCGGCAGGGGAGATGTAACCACCAACTCCAGCTCTGGGAAAGTTCTAA
GCCCAGTGGTGGAGAAGATGCGCCGCGACCGCATCAACAGCAGCATCGAGCAGCTGAAACTGCT
GCTGGAACAGGAGTTCGCGCGGCACCAGCCCAACTCCAAGCTGGAGAAGGCAGACATCCTGGAG
ATGGCCGTCAGCTACCTGAAGCACAGCAAAGCCTTCGCCGCGGCCGCGGGCCCCAAGAGCCTAC
ACCAGGACTACAGCGAGGGCTACTCGTGGTGCCTGCAGGAGGCCGTGCAGTTCCTGACGCTGCA
CGCCGCCAGCGACACGCAGATGAAACTGCTCTACCACTTCCAGCGGCCCTCGGCCGGGTCCACG
GCGCCTGCTAAAGAGCCCCAGGCGTCCAGCGCCGTCGCCCCGCCCGTGCGCTCCTCGGTCAAGG
CAGCGGCCACCGCCGCCGCCGCGCGCCAACCCGCATGCGGCCTCTGGCGGCCCTGGTGACCGGG
CGACTGCGGGGCCGCCCGGTCTAGGACCAGAGGGCGAGCCGTTCCTCTAGAGTGTAGGGAAGAC
CTTCCCAGCCGCAGTCCGGCCCCCGGATGGAACGCACCCTTCTCCGGAAGGCACGCACCCTTCT
CCGGAAGGCTCCCTCCCCAGGCTGGCAGGCCAGCAGGAGGGTCATTCTCAAGAGAATGTGTGCC
ATGTCCTTGTCATTTTAGGACAATCAGGGCCCATTTTCTGCCAAGTGTCTGACCCCAAGGGGTT
GTTCTGTGTTTGCATTTCAGCAAGTGACTTCTGGGAAGTTCCCATTTGCGGGGTTCTATGATAT
TTGTAGGGTCAGGGGCTGGGCCTGCCGAAGCCCCATCCTGTAGAGGACTTTCTTCAGGGCCTGT
TGCTGCTGGGCAGGGCCCCTGCAGGCAGGCCGTGCCGTGGGCACGCTTGCCTTTTGTGAAGGCG
GAACTCCAGGTGTATCCTCATAGGAAGTACTCAGCCTGCTTGGGCGCCTGGACCACGATGTGGT
GGTTCTAAAGTCCACATGGCTTGGATGTCTGGTGAAGGCTCATAGTGGGCTGTTTGGGGAGAGG
GGTCTCCACTATGATCCTTAAAGGATTCCTTTGTGTGGGTGGGTGCACCGCAGGATGATTTTGT
ACTTAGAATTTAAACTCTTCCTCATGTGAGAGCCCATGGACTGCTCTGAAAGCTTCTAATAAAA
TCTATCATTCTTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005339341	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000021535.2
GenBank Protein	KAG3281959	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005339341 ⟸ XM_005339284

- UniProtKB:

I3NAY8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQNGDFLEMVGAMRPPELQGSATDSYHSSRVGEDPEEHLLAPQQPKYHFLGAACARLYAQTLAH
LKLPKVGRGDVTTNSSSGKVLSPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILE
MAVSYLKHSKAFAAAAGPKSLHQDYSEGYSWCLQEAVQFLTLHAASDTQMKLLYHFQRPSAGST
APAKEPQASSAVAPPVRSSVKAAATAAAARQPACGLWRPW

hide sequence

Ensembl Acc Id:

ENSSTOP00000021535 ⟸ ENSSTOT00000024683

Protein Domains

bHLH Orange

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000020897	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000024683.2	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
InterPro	bHLH_dom	UniProtKB/TrEMBL
	HES_HEY	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
	Orange_dom	UniProtKB/TrEMBL
NCBI Gene	Hes5	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR HES-5	UniProtKB/TrEMBL
Pfam	Hairy_orange	UniProtKB/TrEMBL
	HLH	UniProtKB/TrEMBL
PROSITE	BHLH	UniProtKB/TrEMBL
	ORANGE	UniProtKB/TrEMBL
SMART	HLH	UniProtKB/TrEMBL
	ORANGE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/TrEMBL
UniProt	I3NAY8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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