Cpo (carboxypeptidase O) - Rat Genome Database

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Gene: Cpo (carboxypeptidase O) Ictidomys tridecemlineatus
Analyze
Symbol: Cpo
Name: carboxypeptidase O
RGD ID: 12487888
Description: ENCODES a protein that exhibits carboxypeptidase activity (inferred); hydrolase activity (inferred); metallocarboxypeptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); primary pulmonary hypertension (ortholog); FOUND IN extracellular space (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303163,584,430 - 163,609,091 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366313,219,512 - 3,243,462 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366313,219,512 - 3,243,462 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cpo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303163,584,430 - 163,609,091 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366313,219,512 - 3,243,462 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366313,219,512 - 3,243,462 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382206,939,518 - 206,969,474 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2206,939,518 - 206,969,474 (+)EnsemblGRCh38hg38GRCh38
GRCh372207,804,242 - 207,834,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362207,512,569 - 207,542,405 (+)NCBINCBI36Build 36hg18NCBI36
Build 342207,629,829 - 207,659,666NCBI
Celera2201,565,751 - 201,595,665 (+)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2199,654,224 - 199,684,027 (+)NCBIHuRef
CHM1_12207,810,210 - 207,840,080 (+)NCBICHM1_1
T2T-CHM13v2.02207,280,302 - 207,451,686 (+)NCBIT2T-CHM13v2.0
Gm13754
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,957,040 - 63,973,947 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl163,957,007 - 63,975,091 (+)EnsemblGRCm39 Ensembl
GRCm38163,917,881 - 63,934,788 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl163,917,848 - 63,935,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv37163,950,078 - 63,982,506 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36163,950,078 - 63,982,506 (+)NCBIMGSCv36mm8
Celera164,373,071 - 64,451,183 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.31NCBI
Cpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8972,813,802 - 72,832,056 (+)NCBIGRCr8
mRatBN7.2965,319,996 - 65,338,250 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.0970,603,023 - 70,641,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0971,933,276 - 71,971,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4962,556,559 - 62,588,564 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera962,730,209 - 62,748,560 (+)NCBICelera
Cytogenetic Map9q32NCBI
Cpo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554578,011,414 - 8,038,758 (-)NCBIChiLan1.0ChiLan1.0
CPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213109,546,270 - 109,578,990 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B109,417,181 - 109,594,053 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B94,033,058 - 94,205,134 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B212,301,718 - 212,331,611 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B212,301,718 - 212,331,611 (+)Ensemblpanpan1.1panPan2
CPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13715,376,243 - 15,438,914 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3715,413,934 - 15,438,920 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3716,298,203 - 16,323,029 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03715,350,878 - 15,375,720 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3715,350,734 - 15,375,722 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13715,296,690 - 15,321,510 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03715,269,756 - 15,294,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03715,274,718 - 15,299,543 (+)NCBIUU_Cfam_GSD_1.0
CPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15110,165,019 - 110,194,152 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115110,164,979 - 110,194,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215121,719,584 - 121,748,744 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11092,724,991 - 92,756,432 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1092,726,016 - 92,756,393 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040106,623,932 - 106,654,245 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247659,009,452 - 9,038,226 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005335112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000013348   ⟹   ENSSTOP00000011962
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366313,219,512 - 3,243,462 (+)Ensembl
RefSeq Acc Id: XM_005335112   ⟹   XP_005335169
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303163,584,430 - 163,609,091 (+)NCBI
SpeTri2.0NW_0049366313,219,512 - 3,243,462 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005335169 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000011962.2
GenBank Protein KAG3275080 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005335169   ⟸   XM_005335112
- UniProtKB: I3MKU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000011962   ⟸   ENSSTOT00000013348
Protein Domains
Peptidase M14 carboxypeptidase A


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013351 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013348.3 UniProtKB/TrEMBL
Gene3D-CATH Zn peptidases UniProtKB/TrEMBL
InterPro Carboxypeptidase_O UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/TrEMBL
NCBI Gene Cpo ENTREZGENE
PANTHER CARBOXYPEPTIDASE O UniProtKB/TrEMBL
  PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B UniProtKB/TrEMBL
Pfam Peptidase_M14 UniProtKB/TrEMBL
PRINTS CRBOXYPTASEA UniProtKB/TrEMBL
PROSITE CARBOXYPEPT_ZN_1 UniProtKB/TrEMBL
SMART Zn_pept UniProtKB/TrEMBL
Superfamily-SCOP Zn-dependent exopeptidases UniProtKB/TrEMBL
UniProt I3MKU4 ENTREZGENE, UniProtKB/TrEMBL