Ppcs (phosphopantothenoylcysteine synthetase) - Rat Genome Database

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Gene: Ppcs (phosphopantothenoylcysteine synthetase) Ictidomys tridecemlineatus
Analyze
Symbol: Ppcs
Name: phosphopantothenoylcysteine synthetase
RGD ID: 12487734
Description: ENCODES a protein that exhibits catalytic activity (inferred); identical protein binding (inferred); phosphopantothenate--cysteine ligase activity (inferred); INVOLVED IN acetyl-CoA biosynthetic process (inferred); coenzyme A biosynthetic process (inferred); heart process (inferred); PARTICIPATES IN pantothenic acid metabolic pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); dilated cardiomyopathy 2C (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphopantothenate--cysteine ligase; phosphopantothenoylcysteine synthetase, transcript variant X1; phosphopantothenoylcysteine synthetase, transcript variant X2; phosphopantothenoylcysteine synthetase, transcript variant X3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,042,297 - 58,046,179 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647423,867,347 - 23,871,223 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647423,867,117 - 23,870,832 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Ppcs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,042,297 - 58,046,179 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647423,867,347 - 23,871,223 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647423,867,117 - 23,870,832 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPCS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38142,456,341 - 42,473,417 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl142,456,117 - 42,473,385 (+)EnsemblGRCh38hg38GRCh38
GRCh37142,922,012 - 42,939,088 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36142,694,760 - 42,698,673 (+)NCBINCBI36Build 36hg18NCBI36
Celera141,204,112 - 41,208,024 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,042,280 - 41,046,192 (+)NCBIHuRef
CHM1_1143,039,012 - 43,042,924 (+)NCBICHM1_1
T2T-CHM13v2.0142,326,703 - 42,343,779 (+)NCBIT2T-CHM13v2.0
Ppcs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394119,275,724 - 119,279,673 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4119,275,727 - 119,279,617 (-)EnsemblGRCm39 Ensembl
GRCm384119,418,527 - 119,422,440 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,418,530 - 119,422,420 (-)EnsemblGRCm38mm10GRCm38
MGSCv374119,091,138 - 119,095,025 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364118,916,465 - 118,920,352 (-)NCBIMGSCv36mm8
Celera4118,149,698 - 118,153,626 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.38NCBI
Ppcs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,308,394 - 138,312,047 (-)NCBIGRCr8
mRatBN7.25133,023,077 - 133,026,899 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5133,023,121 - 133,026,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5135,751,606 - 135,755,020 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,508,062 - 137,511,476 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,528,672 - 137,532,086 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,466,298 - 138,470,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,466,293 - 138,470,096 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05142,276,595 - 142,279,846 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45140,008,434 - 140,012,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15140,013,626 - 140,017,910 (-)NCBI
Celera5131,547,070 - 131,550,484 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ppcs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,080,865 - 2,085,003 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,080,865 - 2,084,199 (+)NCBIChiLan1.0ChiLan1.0
PPCS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21184,338,463 - 184,355,237 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11183,480,108 - 183,497,012 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,756,403 - 41,773,430 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1143,136,337 - 43,153,583 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl143,136,720 - 43,140,620 (+)Ensemblpanpan1.1panPan2
PPCS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115813,435 - 817,732 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15813,870 - 816,825 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha151,068,253 - 1,071,661 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.015895,016 - 898,424 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl15895,030 - 898,423 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115804,254 - 807,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.015865,779 - 869,187 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015880,894 - 884,302 (-)NCBIUU_Cfam_GSD_1.0
PPCS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6168,870,869 - 168,876,779 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16168,833,945 - 168,876,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26156,392,581 - 156,397,630 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPCS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2090,467,656 - 90,473,704 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603326,435,491 - 26,452,563 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppcs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248921,791,255 - 1,795,250 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248921,791,254 - 1,794,866 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000000111   ⟹   ENSSTOP00000000097
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647423,867,347 - 23,871,223 (+)Ensembl
RefSeq Acc Id: XM_005317887   ⟹   XP_005317944
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505858,042,585 - 58,046,179 (+)NCBI
SpeTri2.0NW_00493647423,867,347 - 23,870,832 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013364581   ⟹   XP_013220035
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505858,042,297 - 58,046,050 (+)NCBI
SpeTri2.0NW_00493647423,867,117 - 23,870,832 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021719574   ⟹   XP_021575249
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505858,043,404 - 58,046,179 (+)NCBI
SpeTri2.0NW_00493647423,868,170 - 23,870,832 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005317944 (Get FASTA)   NCBI Sequence Viewer  
  XP_013220035 (Get FASTA)   NCBI Sequence Viewer  
  XP_021575249 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000000097.2
GenBank Protein KAG3282903 (Get FASTA)   NCBI Sequence Viewer  
  KAG3282904 (Get FASTA)   NCBI Sequence Viewer  
  KAG3282905 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_013220035   ⟸   XM_013364581
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005317944   ⟸   XM_005317887
- Peptide Label: isoform X1
- UniProtKB: I3LVZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021575249   ⟸   XM_021719574
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSTOP00000000097   ⟸   ENSSTOT00000000111
Protein Domains
DNA/pantothenate metabolism flavoprotein C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000111 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000111.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10300 UniProtKB/TrEMBL
InterPro CoaB-like_sf UniProtKB/TrEMBL
  DNA/pantothenate-metab_flavo_C UniProtKB/TrEMBL
NCBI Gene Ppcs ENTREZGENE
PANTHER CORNICHON-RELATED UniProtKB/TrEMBL
  PHOSPHOPANTOTHENATE--CYSTEINE LIGASE UniProtKB/TrEMBL
Pfam DFP UniProtKB/TrEMBL
Superfamily-SCOP SSF102645 UniProtKB/TrEMBL
UniProt I3LVZ7 ENTREZGENE, UniProtKB/TrEMBL