Slc12a6 (solute carrier family 12 member 6) - Rat Genome Database

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Gene: Slc12a6 (solute carrier family 12 member 6) Ictidomys tridecemlineatus
Analyze
Symbol: Slc12a6
Name: solute carrier family 12 member 6
RGD ID: 12483106
Description: ENCODES a protein that exhibits potassium ion transmembrane transporter activity (ortholog); INVOLVED IN cellular hypotonic response (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH agenesis of the corpus callosum with peripheral neuropathy (ortholog); Autosomal Recessive Dyskeratosis Congenita (ortholog); autosomal recessive dyskeratosis congenita 1 (ortholog); FOUND IN apical plasma membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: solute carrier family 12 member 6, transcript variant X1; solute carrier family 12 member 6, transcript variant X2; solute carrier family 12 member 6, transcript variant X3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864079,326,666 - 79,419,750 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366732,727,884 - 2,824,977 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366732,731,454 - 2,825,179 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Slc12a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864079,326,666 - 79,419,750 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366732,727,884 - 2,824,977 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366732,731,454 - 2,825,179 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381534,229,784 - 34,338,057 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1534,229,784 - 34,338,060 (-)EnsemblGRCh38hg38GRCh38
GRCh371534,521,985 - 34,630,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361532,309,489 - 32,417,557 (-)NCBINCBI36Build 36hg18NCBI36
Build 341532,312,957 - 32,398,222NCBI
Celera1511,324,764 - 11,432,905 (-)NCBICelera
Cytogenetic Map15q14NCBI
HuRef1511,385,680 - 11,493,609 (-)NCBIHuRef
CHM1_11534,640,225 - 34,748,321 (-)NCBICHM1_1
T2T-CHM13v2.01532,028,044 - 32,136,362 (-)NCBIT2T-CHM13v2.0
Slc12a6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392112,096,659 - 112,193,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2112,096,170 - 112,193,508 (+)EnsemblGRCm39 Ensembl
GRCm382112,266,314 - 112,363,163 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2112,265,825 - 112,363,163 (+)EnsemblGRCm38mm10GRCm38
MGSCv372112,106,471 - 112,203,320 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362112,067,658 - 112,163,995 (+)NCBIMGSCv36mm8
Celera2113,423,625 - 113,514,137 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.99NCBI
Slc12a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83119,525,521 - 119,624,655 (+)NCBIGRCr8
mRatBN7.2399,071,577 - 99,170,266 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl399,071,391 - 99,170,258 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3102,700,085 - 102,798,582 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03111,299,087 - 111,397,581 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03108,994,676 - 109,092,705 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03103,752,213 - 103,852,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3103,753,238 - 103,852,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03110,347,112 - 110,446,527 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4398,110,547 - 98,212,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1398,005,593 - 98,106,019 (+)NCBI
Celera398,058,005 - 98,155,735 (+)NCBICelera
Cytogenetic Map3q35NCBI
Slc12a6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955416276,987 - 375,812 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955416277,215 - 375,812 (+)NCBIChiLan1.0ChiLan1.0
SLC12A6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21623,012,064 - 23,120,081 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11527,733,836 - 27,841,877 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01512,741,526 - 12,846,894 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11531,575,336 - 31,681,016 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1531,576,756 - 31,680,061 (-)Ensemblpanpan1.1panPan2
SLC12A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.130773,021 - 860,936 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl30773,933 - 858,487 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha30817,004 - 905,364 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.030868,821 - 957,072 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl30868,632 - 957,072 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.130817,202 - 905,323 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.030916,172 - 1,004,333 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0301,043,815 - 1,131,948 (+)NCBIUU_Cfam_GSD_1.0
SLC12A6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl780,164,911 - 80,268,323 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1780,164,788 - 80,266,335 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC12A6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12648,570,399 - 48,673,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2648,589,770 - 48,674,486 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604892,228,864 - 92,332,462 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480431,495 - 105,949 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480431,489 - 105,944 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000000520   ⟹   ENSSTOP00000000469
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366732,733,383 - 2,823,864 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000030347   ⟹   ENSSTOP00000025061
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366732,727,884 - 2,824,977 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000035802   ⟹   ENSSTOP00000026150
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366732,727,884 - 2,823,864 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000038979   ⟹   ENSSTOP00000026535
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366732,727,884 - 2,804,472 (-)Ensembl
RefSeq Acc Id: XM_005337143   ⟹   XP_005337200
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864079,327,824 - 79,419,750 (+)NCBI
SpeTri2.0NW_0049366732,731,454 - 2,824,014 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013363698   ⟹   XP_013219152
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864079,326,666 - 79,419,750 (+)NCBI
SpeTri2.0NW_0049366732,731,454 - 2,825,179 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021734461   ⟹   XP_021590136
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864079,347,414 - 79,419,750 (+)NCBI
SpeTri2.0NW_0049366732,731,454 - 2,804,864 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013219152   ⟸   XM_013363698
- Peptide Label: isoform X1
- UniProtKB: A0A287CUW2 (UniProtKB/TrEMBL),   I3LWT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005337200   ⟸   XM_005337143
- Peptide Label: isoform X2
- UniProtKB: A0A287CXT9 (UniProtKB/TrEMBL),   I3LWT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021590136   ⟸   XM_021734461
- Peptide Label: isoform X3
- UniProtKB: A0A287CYX1 (UniProtKB/TrEMBL),   I3LWT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000026150   ⟸   ENSSTOT00000035802
RefSeq Acc Id: ENSSTOP00000000469   ⟸   ENSSTOT00000000520
RefSeq Acc Id: ENSSTOP00000025061   ⟸   ENSSTOT00000030347
RefSeq Acc Id: ENSSTOP00000026535   ⟸   ENSSTOT00000038979
Protein Domains
Amino acid permease/ SLC12A   SLC12A transporter C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000519 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000520.3 UniProtKB/TrEMBL
  ENSSTOT00000030347.1 UniProtKB/TrEMBL
  ENSSTOT00000035802.1 UniProtKB/TrEMBL
  ENSSTOT00000038979.1 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA-permease/SLC12A_dom UniProtKB/TrEMBL
  KCC1 UniProtKB/TrEMBL
  KCL_cotranspt UniProtKB/TrEMBL
  SLC12_C UniProtKB/TrEMBL
  SLC12A_fam UniProtKB/TrEMBL
NCBI Gene Slc12a6 ENTREZGENE
PANTHER PTHR11827 UniProtKB/TrEMBL
  PTHR11827:SF66 UniProtKB/TrEMBL
Pfam AA_permease UniProtKB/TrEMBL
  SLC12 UniProtKB/TrEMBL
PRINTS KCLTRNSPORT UniProtKB/TrEMBL
  KCLTRNSPORT1 UniProtKB/TrEMBL
UniProt A0A287CUW2 ENTREZGENE, UniProtKB/TrEMBL
  A0A287CXT9 ENTREZGENE, UniProtKB/TrEMBL
  A0A287CYX1 ENTREZGENE, UniProtKB/TrEMBL
  I3LWT7 ENTREZGENE, UniProtKB/TrEMBL