Rfc4 (replication factor C subunit 4)

Gene: Rfc4 (replication factor C subunit 4) Ictidomys tridecemlineatus

Analyze

Symbol:

Rfc4

Name:

replication factor C subunit 4

RGD ID:

12480650

Description:

ENCODES a protein that exhibits DNA clamp loader activity (ortholog); enzyme binding (ortholog); single-stranded DNA helicase activity (ortholog); INVOLVED IN DNA repair (inferred); DNA replication (inferred); DNA-templated DNA replication (inferred); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH 3MC syndrome 1 (ortholog); Animal Disease Models (ortholog); genetic disease (ortholog); FOUND IN Ctf18 RFC-like complex (ortholog); DNA replication factor C complex (ortholog); Elg1 RFC-like complex (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	117,112,167 - 117,127,993 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936578	3,204,035 - 3,219,806 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3MC syndrome 1 (ISO)

Animal Disease Models (ISO)

genetic disease (ISO)

lung adenocarcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA repair (IEA)

DNA replication (IEA)

DNA-templated DNA replication (IEA)

Cellular Component

Ctf18 RFC-like complex (ISO)

DNA replication factor C complex (IEA,ISO)

Elg1 RFC-like complex (ISO)

nucleoplasm (ISO)

nucleus (IEA)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

DNA binding (IEA)

DNA clamp loader activity (IEA,ISO)

enzyme binding (ISO)

protein binding (ISO)

single-stranded DNA helicase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mismatch repair pathway (ISO)

nucleotide excision repair pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Rfc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	117,112,167 - 117,127,993 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936578	3,204,035 - 3,219,806 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RFC4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	186,789,900 - 186,806,482 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	186,789,880 - 186,807,058 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	186,507,689 - 186,524,271 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	187,990,375 - 188,006,984 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	187,990,385 - 188,006,992	NCBI
Celera	3	184,943,843 - 184,960,507 (-)	NCBI		Celera
Cytogenetic Map	3	q27.3	NCBI
HuRef	3	183,917,358 - 183,933,324 (-)	NCBI		HuRef
CHM1_1	3	186,471,258 - 186,488,062 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	189,611,930 - 189,628,517 (-)	NCBI		T2T-CHM13v2.0

Rfc4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	22,932,698 - 22,946,480 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	22,932,693 - 22,946,487 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	23,113,948 - 23,127,730 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	23,113,943 - 23,127,737 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	23,114,021 - 23,127,803 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	23,029,282 - 23,043,064 (-)	NCBI		MGSCv36	mm8
Celera	16	23,672,554 - 23,686,047 (-)	NCBI		Celera
Cytogenetic Map	16	B1	NCBI
cM Map	16	13.93	NCBI

Rfc4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	91,254,273 - 91,268,727 (+)	NCBI		GRCr8
mRatBN7.2	11	77,749,642 - 77,764,123 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	77,749,638 - 77,764,122 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	86,500,114 - 86,514,569 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	79,137,786 - 79,152,227 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	78,214,412 - 78,228,869 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	81,358,592 - 81,373,044 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	81,358,592 - 81,373,043 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	84,396,767 - 84,411,362 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	79,935,273 - 79,950,589 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	79,992,852 - 80,008,178 (+)	NCBI
Celera	11	76,622,175 - 76,636,605 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

Rfc4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	20,948,549 - 20,967,845 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	20,948,549 - 20,967,845 (+)	NCBI	ChiLan1.0	ChiLan1.0

RFC4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	184,666,547 - 184,683,752 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	184,671,254 - 184,688,690 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	183,824,865 - 183,841,895 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	192,290,639 - 192,307,478 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	192,290,639 - 192,307,839 (-)	Ensembl	panpan1.1		panPan2

RFC4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	19,361,024 - 19,377,289 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	19,361,044 - 19,377,294 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	23,446,502 - 23,462,817 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	19,272,394 - 19,288,876 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	19,272,548 - 19,288,832 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	19,303,693 - 19,320,012 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	19,303,699 - 19,320,013 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	19,531,570 - 19,547,898 (-)	NCBI		UU_Cfam_GSD_1.0

RFC4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	124,589,295 - 124,604,426 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	124,589,292 - 124,604,421 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	133,979,667 - 133,994,796 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RFC4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	81,081,415 - 81,097,599 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	81,081,481 - 81,097,272 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	54,573,322 - 54,589,390 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rfc4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	69,979,072 - 69,999,750 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	69,979,038 - 69,999,750 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005330997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005330997 ⟹ XP_005331054

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	117,112,167 - 117,127,993 (+)	NCBI
SpeTri2.0	NW_004936578	3,204,035 - 3,219,806 (+)	NCBI

Sequence:

show sequence

CCCTGCCCTTCGCGGCCGTTCAGTGGCGGGAACCGAGGCGACTGTAGAGACTGCACCTACTGCA
AGTCTTCGGGTCCCGTTATTGTCTGAATTAGGAACAGAGCTGAGACTTTGCCACCACCTCGTCC
TTTTCTCATTCCGGAAGATCCCAGAACGAGCCGGCAGTCCACTCGCTTTGGTGACGAGAGGCTG
AAAGACCCAGGCTCTGCGGTTCCCGCGCGGAAAACAGGGTTTGCAGGGTGAAGTAACCATGCAG
GCATTTCTAAAAGGCACATCTATCAGTACTAAACCACCGTTAACCAAGGATCGAGGAGTAGCTG
CCACTGCAGGGAGCAGTGGTGAGAACAAGAAAGTCAAACATGTTCCATGGGTGGAAAAATATCG
CCCAAAATGTGTAGATGAAGTTGCTTTCCAAGAAGAAGTAGTTGCAGTGTTGAAAAAATCTTTA
GAAGGAGCTGATCTACCTAATCTCTTGTTTTATGGACCACCTGGAACTGGGAAGACATCCACCA
TTTTGGCAGCTGCTAGAGAACTCTTTGGGCCTGAACTATTTCGATTAAGAGTTCTTGAGTTAAA
TGCATCTGATGAACGTGGAATACAAGTAGTTCGAGAGAAGGTGAAAAATTTTGCTCAATTAACT
GTGTCAGGAAGTCGTTCAGATGGGAAGCCATGTCCTCCTTTTAAGATTGTAATTTTGGATGAAG
CTGATTCCATGACCTCAGCTGCTCAGGCCGCTTTAAGACGAACTATGGAGAAAGAATCTAAAAC
CACACGTTTCTGTCTCATCTGTAACTATATTAGTAGAATAATTGAACCCTTGACCTCTAGATGT
TCAAAATTCCGCTTCAAGCCTTTATCAGATAAAACTCAACAGCAGCGATTACTAGACATTGCTG
AGAAGGAAAATGTCAAAATTAGTAATGAGGGAATAGCTTATCTAGTTAAAGTATCAGAGGGAGA
CTTAAGGAAAGCCATTACATTTCTTCAAAGTGCTACTCGATTAACAGGTGGAAAGGAAGTCACG
GAAAAAGTGATCACAGACATTGCTGGGGTTATACCAGCTGAGGCAATTGATGGAATATTTGCTG
CATGTCAGAGTGGCTCCTTTGATAAACTGGAAGCTGCAGTGAAGGAATTGATAGATGAGGGTCA
TGCAGCCACACAACTTATAAATCAACTCCATGATGTGGTTGTAGAAAATGATAACCTTTCTGAC
AAACAGAAGTCCATCATTACAGAAAAGCTTGCGGAAGTTGACAAATGCTTAGCAGATGGCGCTG
ATGAACACCTGCAACTGATTGGCCTGTGTGCAACCCTGATGCAGCAATTAACTCAGAACTGTTA
AAGTCAATAAAGTGAATGACTTTTTGGAAATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005331054	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000011304.2
	ENSSTOP00000029771.1
GenBank Protein	KAG3271123	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005331054 ⟸ XM_005330997

- UniProtKB:

I3MJH9 (UniProtKB/TrEMBL), A0A287D8D8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQAFLKGTSISTKPPLTKDRGVAATAGSSGENKKVKHVPWVEKYRPKCVDEVAFQEEVVAVLKK
SLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQ
LTVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYISRIIEPLTS
RCSKFRFKPLSDKTQQQRLLDIAEKENVKISNEGIAYLVKVSEGDLRKAITFLQSATRLTGGKE
VTEKVITDIAGVIPAEAIDGIFAACQSGSFDKLEAAVKELIDEGHAATQLINQLHDVVVENDNL
SDKQKSIITEKLAEVDKCLADGADEHLQLIGLCATLMQQLTQNC

hide sequence

Protein Domains

AAA+ ATPase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000012616	UniProtKB/TrEMBL
	ENSSTOG00000029469	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000012613.3	UniProtKB/TrEMBL
	ENSSTOT00000039946.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.8.60	UniProtKB/TrEMBL
	1.20.272.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	AAA+_ATPase	UniProtKB/TrEMBL
	ATPase_AAA_core	UniProtKB/TrEMBL
	DNA_pol3_clamp-load_cplx_C	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Rep_factorC_C	UniProtKB/TrEMBL
	RFC_lid	UniProtKB/TrEMBL
NCBI Gene	Rfc4	ENTREZGENE
PANTHER	REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT	UniProtKB/TrEMBL
	REPLICATION FACTOR C SUBUNIT 4	UniProtKB/TrEMBL
Pfam	AAA	UniProtKB/TrEMBL
	Rep_fac_C	UniProtKB/TrEMBL
SMART	AAA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48019	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A287D8D8	ENTREZGENE, UniProtKB/TrEMBL
	I3MJH9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations