Nlgn1 (neuroligin 1) - Rat Genome Database

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Gene: Nlgn1 (neuroligin 1) Ictidomys tridecemlineatus
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Symbol: Nlgn1
Name: neuroligin 1
RGD ID: 12472321
Description: ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); identical protein binding (ortholog); neurexin family protein binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); inhibitory postsynaptic potential (ortholog); long-term synaptic potentiation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); status epilepticus (ortholog); FOUND IN dendrite (ortholog); dendritic shaft (ortholog); dendritic spine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC110599465; neuroligin-1; neuroligin-1-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602104,390,734 - 105,051,988 (+)NCBI
SpeTri2.0NW_004936703951,935 - 1,415,991 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
AMPA glutamate receptor clustering  (IEA)
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  (IEA)
cell adhesion  (IEA)
cellular response to calcium ion  (ISO)
cytoskeletal matrix organization at active zone  (IEA)
establishment of protein localization  (IEA)
excitatory synapse assembly  (IEA)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  (IEA)
inhibitory postsynaptic potential  (ISO)
long-term synaptic potentiation  (ISO)
membrane assembly  (IEA)
modulation of chemical synaptic transmission  (IEA,ISO)
negative regulation of dendritic spine morphogenesis  (IEA)
nervous system development  (IEA)
neurexin clustering involved in presynaptic membrane assembly  (IEA)
neuron cell-cell adhesion  (IEA)
neuron projection arborization  (ISO)
neuron projection development  (ISO)
NMDA glutamate receptor clustering  (ISO)
positive regulation of circadian sleep/wake cycle, wakefulness  (IEA)
positive regulation of dendritic spine development  (IEA,ISO)
positive regulation of excitatory postsynaptic potential  (IEA)
positive regulation of filopodium assembly  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of presynaptic active zone assembly  (ISO)
positive regulation of protein localization to synapse  (ISO)
positive regulation of ruffle assembly  (ISO)
positive regulation of synapse assembly  (IEA,ISO)
positive regulation of synaptic transmission, GABAergic  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of synaptic vesicle clustering  (IEA)
positive regulation of synaptic vesicle endocytosis  (IEA)
positive regulation of synaptic vesicle exocytosis  (IEA)
postsynaptic density protein 95 clustering  (IEA)
postsynaptic membrane assembly  (IEA)
postsynaptic specialization assembly  (IEA)
presynaptic membrane assembly  (IEA)
protein localization to synapse  (IEA)
protein targeting  (ISO)
receptor localization to synapse  (IEA)
regulation of AMPA receptor activity  (ISO)
regulation of localization  (IEA)
regulation of membrane potential  (IEA)
regulation of nervous system process  (IEA)
regulation of neuron differentiation  (IEA)
regulation of NMDA receptor activity  (IEA)
regulation of presynapse organization  (ISO)
regulation of respiratory gaseous exchange by nervous system process  (IEA,ISO)
regulation of signal transduction  (IEA)
retrograde trans-synaptic signaling by trans-synaptic protein complex  (ISO)
synapse assembly  (IEA,ISO)
synapse organization  (IEA,ISO)
synaptic membrane adhesion  (IEA)
synaptic vesicle clustering  (IEA)
synaptic vesicle targeting  (IEA)
synaptic vesicle transport  (ISO)
terminal button organization  (IEA)

References

Genomics

Comparative Map Data
Nlgn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602104,390,734 - 105,051,988 (+)NCBI
SpeTri2.0NW_004936703951,935 - 1,415,991 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLGN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383173,395,952 - 174,294,372 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3173,396,284 - 174,294,372 (+)EnsemblGRCh38hg38GRCh38
GRCh373173,113,742 - 174,012,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363174,598,938 - 175,483,810 (+)NCBINCBI36hg18NCBI36
Build 343174,598,945 - 175,483,818NCBI
Celera3171,515,223 - 172,400,529 (+)NCBI
Cytogenetic Map3q26.31NCBI
HuRef3170,489,300 - 171,374,847 (+)NCBIHuRef
CHM1_13173,079,120 - 173,964,074 (+)NCBICHM1_1
Nlgn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39325,475,972 - 26,387,504 (-)NCBIGRCm39mm39
GRCm39 Ensembl325,480,379 - 26,386,609 (-)Ensembl
GRCm38325,421,808 - 26,332,866 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl325,426,215 - 26,332,460 (-)EnsemblGRCm38mm10GRCm38
MGSCv37325,330,763 - 26,230,831 (-)NCBIGRCm37mm9NCBIm37
MGSCv36325,622,914 - 26,522,982 (-)NCBImm8
Celera325,414,194 - 26,317,921 (-)NCBICelera
Cytogenetic Map3A3NCBI
Nlgn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22108,256,236 - 109,181,530 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2108,257,824 - 109,002,464 (-)Ensembl
Rnor_6.02111,057,291 - 111,973,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2111,057,291 - 111,793,326 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02130,770,580 - 131,688,440 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42111,189,470 - 111,948,145 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12111,133,661 - 111,893,471 (-)NCBI
Celera2103,515,760 - 104,229,754 (-)NCBICelera
Cytogenetic Map2q24NCBI
Nlgn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554203,549,021 - 4,167,493 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554203,360,745 - 4,171,587 (+)NCBIChiLan1.0ChiLan1.0
NLGN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13178,595,014 - 179,505,810 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3178,810,253 - 179,503,756 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03170,416,885 - 171,333,094 (+)NCBIMhudiblu_PPA_v0panPan3
NLGN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13437,397,772 - 38,203,634 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3437,572,629 - 38,203,177 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3446,409,660 - 47,225,945 (+)NCBI
ROS_Cfam_1.03437,484,369 - 38,313,800 (+)NCBI
ROS_Cfam_1.0 Ensembl3437,659,077 - 38,308,775 (+)Ensembl
UMICH_Zoey_3.13437,576,956 - 38,230,342 (+)NCBI
UNSW_CanFamBas_1.03437,390,518 - 38,201,245 (+)NCBI
UU_Cfam_GSD_1.03437,647,698 - 38,463,980 (+)NCBI
NLGN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13112,036,053 - 112,725,618 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113111,851,007 - 112,727,202 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213120,802,484 - 121,025,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NLGN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11515,129,976 - 16,017,107 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606323,867,631 - 24,767,924 (-)NCBIVero_WHO_p1.0
Nlgn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473051,451,546 - 52,300,413 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_021735102   ⟹   XP_021590777
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602104,390,734 - 105,051,988 (+)NCBI
SpeTri2.0NW_004936703951,935 - 1,415,991 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040270102   ⟹   XP_040126036
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602104,390,734 - 105,051,988 (+)NCBI
RefSeq Acc Id: XM_040270103   ⟹   XP_040126037
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602104,390,734 - 105,051,988 (+)NCBI
RefSeq Acc Id: XM_040270104   ⟹   XP_040126038
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602104,390,734 - 105,051,988 (+)NCBI
RefSeq Acc Id: XM_040270105   ⟹   XP_040126039
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602104,390,734 - 105,051,988 (+)NCBI
RefSeq Acc Id: XM_040270106   ⟹   XP_040126040
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602104,390,734 - 105,051,988 (+)NCBI
RefSeq Acc Id: XM_040270107   ⟹   XP_040126041
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602104,390,734 - 105,051,988 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_021590777   ⟸   XM_021735102
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_040126036   ⟸   XM_040270102
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040126037   ⟸   XM_040270103
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040126039   ⟸   XM_040270105
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040126038   ⟸   XM_040270104
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040126040   ⟸   XM_040270106
- Peptide Label: isoform X6
RefSeq Acc Id: XP_040126041   ⟸   XM_040270107
- Peptide Label: isoform X7
Protein Domains
COesterase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009631 UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000008641 UniProtKB/TrEMBL
  ENSSTOP00000028001 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009632 UniProtKB/TrEMBL
  ENSSTOT00000042548 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/TrEMBL
  Nlgn UniProtKB/TrEMBL
  NLGN1 UniProtKB/TrEMBL
NCBI Gene Nlgn1 ENTREZGENE
PANTHER PTHR43903:SF2 UniProtKB/TrEMBL
Pfam COesterase UniProtKB/TrEMBL
PRINTS NEUROLIGIN UniProtKB/TrEMBL
PROSITE CARBOXYLESTERASE_B_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A287D348_ICTTR UniProtKB/TrEMBL
  I3MDX5_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-25 Nlgn1  neuroligin 1  LOC110599465  neuroligin-1-like  Data Merged 737654 PROVISIONAL