Tamalin (trafficking regulator and scaffold protein tamalin) - Rat Genome Database

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Gene: Tamalin (trafficking regulator and scaffold protein tamalin) Ictidomys tridecemlineatus
Analyze
Symbol: Tamalin
Name: trafficking regulator and scaffold protein tamalin (Ensembl:general receptor for phosphoinositides 1 associated scaffold protein)
RGD ID: 12470221
Description: ENCODES a protein that exhibits identical protein binding (ortholog); PDZ domain binding (ortholog); small GTPase binding (ortholog); INVOLVED IN regulation of postsynaptic neurotransmitter receptor internalization (ortholog); signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); syndromic microphthalmia 5 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Grasp
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,697,480 - 63,706,368 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,458,444 - 9,467,351 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,458,549 - 9,467,350 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tamalin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,697,480 - 63,706,368 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,458,444 - 9,467,351 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,458,549 - 9,467,350 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAMALIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,006,946 - 52,015,889 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,006,946 - 52,015,889 (+)EnsemblGRCh38hg38GRCh38
GRCh371252,400,730 - 52,409,673 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,687,015 - 50,695,938 (+)NCBINCBI36Build 36hg18NCBI36
Build 341250,687,014 - 50,695,938NCBI
Celera1251,203,041 - 51,211,963 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,433,882 - 49,442,831 (+)NCBIHuRef
CHM1_11252,367,010 - 52,375,941 (+)NCBICHM1_1
T2T-CHM13v2.01251,970,517 - 51,979,459 (+)NCBIT2T-CHM13v2.0
Tamalin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,122,088 - 101,130,637 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,122,069 - 101,130,637 (+)EnsemblGRCm39 Ensembl
GRCm3815101,224,207 - 101,232,756 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,224,188 - 101,232,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,054,638 - 101,063,187 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,052,243 - 101,066,427 (+)NCBIMGSCv36mm8
Celera15103,372,533 - 103,381,084 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.57NCBI
Tamalin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,217,612 - 134,225,378 (+)NCBIGRCr8
mRatBN7.27132,338,900 - 132,359,519 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,338,900 - 132,346,666 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,140,744 - 134,148,514 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,370,258 - 136,378,028 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,280,692 - 136,288,521 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,869,785 - 142,877,551 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,869,752 - 142,878,347 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,670,666 - 140,678,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,970,173 - 139,977,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,046,609 - 140,054,376 (+)NCBI
Celera7128,804,534 - 128,812,273 (+)NCBICelera
Cytogenetic Map7q36NCBI
Tamalin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,377,702 - 2,385,277 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555472,377,612 - 2,385,918 (+)NCBIChiLan1.0ChiLan1.0
TAMALIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,179,596 - 42,188,252 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,176,359 - 42,185,012 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,747,159 - 36,755,812 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,523,542 - 37,531,996 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,524,232 - 37,531,927 (-)Ensemblpanpan1.1panPan2
TAMALIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,981,261 - 3,000,648 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,255,149 - 43,262,297 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,991,005 - 2,998,190 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,990,639 - 2,998,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,007,624 - 3,014,858 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,994,165 - 3,001,323 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,653,334 - 43,660,493 (+)NCBIUU_Cfam_GSD_1.0
TAMALIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,355,883 - 17,366,309 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1517,357,625 - 17,366,033 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,942,982 - 17,953,496 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAMALIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,176,394 - 48,184,985 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,176,413 - 48,184,981 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037197,905,422 - 197,914,003 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tamalin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816312,476 - 323,192 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624816314,841 - 322,696 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005324978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000000485   ⟹   ENSSTOP00000000437
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365129,458,444 - 9,467,351 (+)Ensembl
RefSeq Acc Id: XM_005324978   ⟹   XP_005325035
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494563,697,480 - 63,706,368 (-)NCBI
SpeTri2.0NW_0049365129,458,549 - 9,467,350 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005325035 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000000437.2
GenBank Protein KAG3291926 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005325035   ⟸   XM_005324978
- UniProtKB: I3LWQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000000437   ⟸   ENSSTOT00000000485
Protein Domains
PDZ


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000486 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000485.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
InterPro PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
NCBI Gene Grasp ENTREZGENE
PANTHER GENERAL RECEPTOR FOR PHOSPHOINOSITIDES 1-ASSOCIATED SCAFFOLD PROTEIN-RELATED UniProtKB/TrEMBL
  PROTEIN TAMALIN UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/TrEMBL
UniProt I3LWQ8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-18 Tamalin  trafficking regulator and scaffold protein tamalin  Grasp  general receptor for phosphoinositides 1 associated scaffold protein  Symbol and/or name change 5135510 APPROVED