Syk (spleen associated tyrosine kinase) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Syk (spleen associated tyrosine kinase) Ictidomys tridecemlineatus
Analyze
Symbol: Syk
Name: spleen associated tyrosine kinase
RGD ID: 12466396
Description: ENCODES a protein that exhibits ATP binding (ortholog); integrin binding (ortholog); interleukin-15 receptor binding (ortholog); INVOLVED IN activation of JUN kinase activity (ortholog); activation of MAPK activity (ortholog); B cell receptor signaling pathway (ortholog); PARTICIPATES IN eicosanoid signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH anti-basement membrane glomerulonephritis (ortholog); colitis (ortholog); long QT syndrome (ortholog); FOUND IN B cell receptor complex (ortholog); cytoplasm (ortholog); early phagosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: tyrosine-protein kinase SYK
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367801,553,605 - 1,601,036 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of JUN kinase activity  (ISO)
activation of MAPK activity  (ISO)
B cell receptor signaling pathway  (ISO)
beta selection  (ISO)
blood vessel morphogenesis  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to molecule of fungal origin  (ISO)
collagen-activated tyrosine kinase receptor signaling pathway  (ISO)
defense response to bacterium  (ISO)
enzyme linked receptor protein signaling pathway  (ISO)
innate immune response  (ISO)
integrin-mediated signaling pathway  (ISO)
interleukin-3-mediated signaling pathway  (ISO)
intracellular signal transduction  (ISO)
leukocyte activation involved in immune response  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukotriene biosynthetic process  (ISO)
lymph vessel development  (ISO)
macrophage activation involved in immune response  (ISO)
neutrophil activation involved in immune response  (ISO)
neutrophil chemotaxis  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of alpha-beta T cell differentiation  (ISO)
positive regulation of alpha-beta T cell proliferation  (ISO)
positive regulation of B cell differentiation  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-3 production  (ISO)
positive regulation of interleukin-4 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of killing of cells of other organism  (ISO)
positive regulation of mast cell degranulation  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of peptidyl-tyrosine autophosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (ISO)
protein autophosphorylation  (ISO)
protein import into nucleus  (ISO)
protein phosphorylation  (ISO)
receptor internalization  (ISO)
regulation of arachidonic acid secretion  (ISO)
regulation of DNA-binding transcription factor activity  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of immune response  (ISO)
regulation of neutrophil degranulation  (ISO)
regulation of phagocytosis  (ISO)
regulation of platelet activation  (ISO)
regulation of platelet aggregation  (ISO)
regulation of superoxide anion generation  (ISO)
regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
serotonin secretion  (ISO)
serotonin secretion by platelet  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Syk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367801,553,605 - 1,601,036 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl990,801,787 - 90,898,549 (+)EnsemblGRCh38hg38GRCh38
GRCh38990,801,600 - 90,898,549 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37993,563,882 - 93,660,831 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36992,603,891 - 92,698,305 (+)NCBINCBI36hg18NCBI36
Build 34990,643,624 - 90,738,036NCBI
Celera963,998,674 - 64,095,487 (+)NCBI
Cytogenetic Map9q22.2NCBI
HuRef963,244,666 - 63,341,118 (+)NCBIHuRef
CHM1_1993,710,434 - 93,807,287 (+)NCBICHM1_1
Syk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391352,736,670 - 52,802,828 (+)NCBIGRCm39mm39
GRCm39 Ensembl1352,737,209 - 52,802,828 (+)Ensembl
GRCm381352,582,610 - 52,648,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1352,583,173 - 52,648,792 (+)EnsemblGRCm38mm10GRCm38
MGSCv371352,692,251 - 52,744,161 (+)NCBIGRCm37mm9NCBIm37
MGSCv361352,609,314 - 52,661,224 (+)NCBImm8
Celera1353,673,505 - 53,725,528 (+)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1327.41NCBI
Syk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21712,604,615 - 12,678,437 (-)NCBI
Rnor_6.0 Ensembl1712,614,311 - 12,669,573 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01712,614,311 - 12,669,568 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01714,703,903 - 14,759,160 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41718,440,672 - 18,498,001 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11718,440,671 - 18,498,006 (-)NCBI
Celera1712,367,624 - 12,424,213 (-)NCBICelera
RH 3.4 Map17126.2RGD
Cytogenetic Map17p14NCBI
Syk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555151,328,630 - 1,380,581 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555151,328,793 - 1,400,206 (-)NCBIChiLan1.0ChiLan1.0
SYK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1989,959,599 - 90,056,101 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl989,959,599 - 90,056,101 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0961,859,767 - 61,956,619 (+)NCBIMhudiblu_PPA_v0panPan3
SYK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl195,903,566 - 95,955,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1195,903,501 - 95,955,577 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
SYK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl142,056,712 - 2,161,172 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1142,103,706 - 2,160,886 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2142,866,432 - 2,869,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SYK
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112101,254,085 - 101,374,724 (+)NCBI
ChlSab1.1 Ensembl12101,260,061 - 101,349,856 (+)Ensembl
Syk
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248681,654,079 - 1,738,648 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005340228   ⟹   XP_005340285
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049367801,553,605 - 1,601,036 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005340285 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005340285   ⟸   XM_005340228
- Sequence:
Protein Domains
Protein kinase   SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000005790 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000005180 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000022396 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005792 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOT00000019999 UniProtKB/TrEMBL
Gene3D-CATH 1.10.930.10 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Kinase_SYK/ZAP-70_inter-SH2_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SYK/ZAP-70_N_SH2 UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_SYK/ZAP70 UniProtKB/TrEMBL
NCBI Gene Syk ENTREZGENE
Pfam Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PIRSF TyrPK_SYK UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt I3M6P2_ICTTR UniProtKB/TrEMBL
  I3NDE9_ICTTR UniProtKB/TrEMBL