Wt1 (WT1 transcription factor) - Rat Genome Database

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Gene: Wt1 (WT1 transcription factor) Ictidomys tridecemlineatus
Analyze
Symbol: Wt1
Name: WT1 transcription factor
RGD ID: 12465138
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN adrenal cortex formation (ortholog); apoptotic process (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Alzheimer's disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear speck (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Wilms tumor 1; Wilms tumor 1, transcript variant X1; Wilms tumor 1, transcript variant X2; Wilms tumor 1, transcript variant X3; Wilms tumor 1, transcript variant X4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494732,287,144 - 32,334,902 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365335,411,848 - 5,459,693 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365335,411,949 - 5,459,693 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
Alzheimer's disease  (ISO)
aniridia  (ISO)
aniridia 1  (ISO)
atypical hemolytic-uremic syndrome  (ISO)
B-cell acute lymphoblastic leukemia  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
B-lymphoblastic leukemia/lymphoma MLL rearranged  (ISO)
benign familial hematuria  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Chromosome 11p Deletion Syndrome  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
Colonic Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Denys-Drash syndrome  (ISO)
Diaphragmatic Hernia  (ISO)
Diffuse Mesangial Sclerosis  (ISO)
disorder of sexual development  (ISO)
endometrial cancer  (ISO)
focal segmental glomerulosclerosis  (ISO)
Frasier syndrome  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
gonadal dysgenesis  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Leber congenital amaurosis 10  (ISO)
leukemia  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
Male Genital Neoplasms  (ISO)
malignant mesothelioma  (ISO)
Meacham Winn Culler Syndrome  (ISO)
Mesothelioma  (ISO)
nemaline myopathy 2  (ISO)
nephroblastoma  (ISO)
nephrotic syndrome  (ISO)
nephrotic syndrome type 1  (ISO)
nephrotic syndrome type 2  (ISO)
nephrotic syndrome type 4  (ISO)
neurilemmoma  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
ovarian serous carcinoma  (ISO)
pancreatic cancer  (ISO)
Peritoneal Neoplasms  (ISO)
primary ovarian insufficiency  (ISO)
proteinuria  (ISO)
renal Wilms' tumor  (ISO)
spermatogenic failure 57  (ISO)
WAGR syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal cortex formation  (ISO)
adrenal gland development  (IEA)
apoptotic process  (ISO)
branching involved in ureteric bud morphogenesis  (IEA)
camera-type eye development  (ISO)
cardiac muscle cell fate commitment  (ISO)
cellular response to cAMP  (IEA)
cellular response to gonadotropin stimulus  (IEA)
diaphragm development  (ISO)
epithelial cell differentiation  (ISO)
flagellated sperm motility  (ISO)
germ cell development  (ISO)
glomerular basement membrane development  (IEA)
glomerulus development  (IEA)
gonad development  (ISO)
heart development  (IEA)
kidney development  (IEA)
male genitalia development  (ISO)
male gonad development  (IEA,ISO)
mesenchymal cell apoptotic process involved in metanephros development  (ISO)
mesenchymal to epithelial transition  (ISO)
mesonephros development  (ISO)
metanephric comma-shaped body morphogenesis  (ISO)
metanephric epithelium development  (IEA)
metanephric mesenchyme development  (ISO)
metanephric S-shaped body morphogenesis  (IEA)
metanephros development  (ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of female gonad development  (ISO)
negative regulation of gene expression via chromosomal CpG island methylation  (IEA,ISO)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (ISO)
negative regulation of metanephric glomerular mesangial cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of translation  (ISO)
podocyte development  (ISO)
podocyte differentiation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of heart growth  (ISO)
positive regulation of male gonad development  (ISO)
positive regulation of metanephric ureteric bud development  (ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
posterior mesonephric tubule development  (ISO)
regulation of animal organ formation  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
RNA splicing  (ISO)
seminiferous tubule development  (ISO)
Sertoli cell development  (ISO)
sex determination  (IEA,ISO)
single fertilization  (ISO)
spermatogenesis  (ISO)
thorax and anterior abdomen determination  (ISO)
ureteric bud development  (ISO)
vasculogenesis  (ISO)
visceral serous pericardium development  (IEA)

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nuclear speck  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494732,287,144 - 32,334,902 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365335,411,848 - 5,459,693 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365335,411,949 - 5,459,693 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381132,387,775 - 32,435,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1132,387,775 - 32,435,564 (-)EnsemblGRCh38hg38GRCh38
GRCh371132,409,321 - 32,457,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361132,365,901 - 32,413,663 (-)NCBINCBI36Build 36hg18NCBI36
Build 341132,365,896 - 32,413,653NCBI
Celera1132,556,060 - 32,603,819 (-)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1132,104,249 - 32,152,010 (-)NCBIHuRef
CHM1_11132,409,251 - 32,457,017 (-)NCBICHM1_1
T2T-CHM13v2.01132,523,264 - 32,571,024 (-)NCBIT2T-CHM13v2.0
Wt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392104,956,874 - 105,003,959 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2104,956,874 - 105,003,961 (+)EnsemblGRCm39 Ensembl
GRCm382105,126,529 - 105,173,614 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2105,126,529 - 105,173,616 (+)EnsemblGRCm38mm10GRCm38
MGSCv372104,966,686 - 105,013,771 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362104,927,368 - 104,974,451 (+)NCBIMGSCv36mm8
Celera2106,361,212 - 106,408,919 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map255.06NCBI
Wt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83112,019,721 - 112,068,454 (+)NCBIGRCr8
mRatBN7.2391,566,540 - 91,613,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl391,567,001 - 91,613,643 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx395,059,051 - 95,105,563 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03103,657,999 - 103,704,505 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03101,489,766 - 101,536,390 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0395,133,221 - 95,180,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl395,133,713 - 95,180,564 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03101,756,056 - 101,802,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4390,529,704 - 90,577,280 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1390,463,925 - 90,472,651 (+)NCBI
Celera390,623,287 - 90,669,803 (+)NCBICelera
RH 3.4 Map3720.19RGD
Cytogenetic Map3q33NCBI
Wt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547610,464,616 - 10,504,473 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547610,464,688 - 10,504,473 (-)NCBIChiLan1.0ChiLan1.0
WT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2934,594,171 - 34,645,602 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11134,598,573 - 34,650,053 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01132,349,807 - 32,398,494 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,238,720 - 32,282,879 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,238,720 - 32,287,249 (-)Ensemblpanpan1.1panPan2
WT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11835,099,660 - 35,148,767 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1835,103,934 - 35,148,000 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1834,713,394 - 34,762,525 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01835,710,611 - 35,759,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1835,710,238 - 35,759,076 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11835,281,214 - 35,330,461 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01834,861,742 - 34,911,460 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01835,497,531 - 35,546,777 (+)NCBIUU_Cfam_GSD_1.0
WT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl228,411,803 - 28,455,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1228,411,467 - 28,456,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2230,902,160 - 30,946,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p14-q11NCBI
WT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1132,750,300 - 32,801,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038129,915,480 - 129,964,047 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476620,900,676 - 20,937,202 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476620,899,546 - 20,937,084 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000027251   ⟹   ENSSTOP00000016765
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365335,411,848 - 5,459,693 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000037232   ⟹   ENSSTOP00000027275
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365335,416,581 - 5,458,438 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000041686   ⟹   ENSSTOP00000024369
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365335,416,581 - 5,458,438 (+)Ensembl
RefSeq Acc Id: XM_005327443   ⟹   XP_005327500
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494732,287,144 - 32,334,902 (+)NCBI
SpeTri2.0NW_0049365335,411,949 - 5,459,693 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021727845   ⟹   XP_021583520
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494732,291,786 - 32,334,268 (+)NCBI
SpeTri2.0NW_0049365335,416,581 - 5,459,693 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021727846   ⟹   XP_021583521
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494732,291,527 - 32,334,902 (+)NCBI
SpeTri2.0NW_0049365335,416,581 - 5,458,850 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040284552   ⟹   XP_040140486
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494732,287,399 - 32,334,902 (+)NCBI
RefSeq Acc Id: XM_040284553   ⟹   XP_040140487
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494732,291,525 - 32,334,902 (+)NCBI
RefSeq Acc Id: XP_005327500   ⟸   XM_005327443
- Peptide Label: isoform X1
- UniProtKB: I3MXC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021583520   ⟸   XM_021727845
- Peptide Label: isoform X4
- UniProtKB: A0A287D1A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021583521   ⟸   XM_021727846
- Peptide Label: isoform X5
- UniProtKB: A0A287CSV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040140486   ⟸   XM_040284552
- Peptide Label: isoform X2
- UniProtKB: I3MXC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040140487   ⟸   XM_040284553
- Peptide Label: isoform X3
Ensembl Acc Id: ENSSTOP00000024369   ⟸   ENSSTOT00000041686
Ensembl Acc Id: ENSSTOP00000027275   ⟸   ENSSTOT00000037232
Ensembl Acc Id: ENSSTOP00000016765   ⟸   ENSSTOT00000027251
Protein Domains
C2H2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000023716 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000027251.2 UniProtKB/TrEMBL
  ENSSTOT00000037232.1 UniProtKB/TrEMBL
  ENSSTOT00000041686.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Wilms_tumour_N UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene Wt1 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 16 UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
Pfam WT1 UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PRINTS WILMSTUMOUR UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A287CSV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D1A5 ENTREZGENE, UniProtKB/TrEMBL
  I3MXC0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 Wt1  WT1 transcription factor    Wilms tumor 1  Symbol and/or name change 5135510 APPROVED