Rapgef4 (Rap guanine nucleotide exchange factor 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Rapgef4 (Rap guanine nucleotide exchange factor 4) Ictidomys tridecemlineatus
Analyze
Symbol: Rapgef4
Name: Rap guanine nucleotide exchange factor 4
RGD ID: 12463385
Description: ENCODES a protein that exhibits cAMP binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); brain development (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Burns (ortholog); split hand-foot malformation 5 (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303134,168,378 - 134,452,112 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365092,722,428 - 3,005,288 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365092,722,279 - 3,006,436 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

References

Genomics

Comparative Map Data
Rapgef4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303134,168,378 - 134,452,112 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365092,722,428 - 3,005,288 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365092,722,279 - 3,006,436 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382172,735,318 - 173,052,893 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2172,735,274 - 173,052,893 (+)EnsemblGRCh38hg38GRCh38
GRCh372173,600,573 - 173,917,621 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362173,308,771 - 173,625,867 (+)NCBINCBI36Build 36hg18NCBI36
Build 342173,426,113 - 173,743,122NCBI
Celera2167,213,920 - 167,531,026 (+)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2165,478,909 - 165,797,009 (+)NCBIHuRef
CHM1_12173,607,657 - 173,924,727 (+)NCBICHM1_1
T2T-CHM13v2.02173,222,337 - 173,539,439 (+)NCBIT2T-CHM13v2.0
Rapgef4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39271,811,559 - 72,087,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl271,811,584 - 72,087,818 (+)EnsemblGRCm39 Ensembl
GRCm38271,981,215 - 72,257,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl271,981,240 - 72,257,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37271,819,344 - 72,094,433 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36271,782,126 - 72,057,215 (+)NCBIMGSCv36mm8
Celera273,684,323 - 73,945,757 (+)NCBICelera
Cytogenetic Map2C3NCBI
Rapgef4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2356,809,388 - 57,101,332 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,809,270 - 57,102,316 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx360,204,514 - 60,496,004 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0368,788,153 - 69,079,646 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0366,553,199 - 66,844,692 (+)NCBIRnor_WKY
Rnor_6.0358,632,338 - 58,925,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl358,632,476 - 58,924,038 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0365,122,705 - 65,409,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4354,396,312 - 54,717,148 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1354,578,917 - 54,613,517 (+)NCBI
Celera356,352,070 - 56,643,335 (+)NCBICelera
Cytogenetic Map3q23NCBI
Rapgef4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554492,171,924 - 2,462,451 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554492,172,354 - 2,453,367 (-)NCBIChiLan1.0ChiLan1.0
RAPGEF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B177,485,404 - 177,794,769 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B177,655,733 - 177,793,644 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B60,022,738 - 60,339,981 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RAPGEF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13617,087,488 - 17,323,504 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3617,087,488 - 17,323,220 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3617,044,798 - 17,327,450 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03617,166,818 - 17,450,241 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3617,166,807 - 17,450,214 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13617,247,410 - 17,530,838 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03617,246,048 - 17,529,604 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03617,349,948 - 17,632,781 (+)NCBIUU_Cfam_GSD_1.0
RAPGEF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1578,773,266 - 79,095,040 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11578,773,270 - 79,094,490 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21588,093,533 - 88,416,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11058,233,503 - 58,549,337 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1058,233,654 - 58,549,331 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040141,024,710 - 141,334,996 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478710,062,717 - 10,369,632 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478710,062,677 - 10,369,132 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005324601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000001725   ⟹   ENSSTOP00000001541
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365092,722,428 - 3,005,288 (+)Ensembl
RefSeq Acc Id: XM_005324601   ⟹   XP_005324658
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303134,168,378 - 134,452,112 (+)NCBI
SpeTri2.0NW_0049365092,722,279 - 3,006,436 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005324658 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005324658   ⟸   XM_005324601
- Sequence:
RefSeq Acc Id: ENSSTOP00000001541   ⟸   ENSSTOT00000001725

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000001541 ENTREZGENE
  ENSSTOP00000001541.3 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001725.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.840.10 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  DEP_dom UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene Rapgef4 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF48366 UniProtKB/TrEMBL
  SSF51206 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt I3LZ38_ICTTR UniProtKB/TrEMBL