Wdr70 (WD repeat domain 70) - Rat Genome Database

Name: Wdr70
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Wdr70 (WD repeat domain 70) Ictidomys tridecemlineatus

Analyze

Symbol:

Wdr70

Name:

WD repeat domain 70

RGD ID:

12462154

Description:

ENCODES a protein that exhibits enzyme binding (inferred); ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN nucleus (inferred); site of double-strand break (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

WD repeat-containing protein 70

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WDR70 (WD repeat domain 70)	NCBI	Ortholog
Mus musculus (house mouse):	Wdr70 (WD repeat domain 70)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Wdr70 (WD repeat domain 70)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Wdr70 (WD repeat domain 70)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WDR70 (WD repeat domain 70)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WDR70 (WD repeat domain 70)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WDR70 (WD repeat domain 70)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	WDR70 (WD repeat domain 70)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Wdr70 (WD repeat domain 70)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	226,748,679 - 227,027,873 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936518	4,343,962 - 4,623,015 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936518	4,343,919 - 4,623,136 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Developmental Disabilities (ISO)

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

nucleus (IEA)

site of double-strand break (IEA)

Molecular Function

enzyme binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Wdr70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	226,748,679 - 227,027,873 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936518	4,343,962 - 4,623,015 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936518	4,343,919 - 4,623,136 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WDR70
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	37,379,318 - 37,753,435 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	37,379,285 - 37,753,435 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	37,379,420 - 37,753,537 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	37,415,169 - 37,788,531 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	37,266,337 - 37,639,153 (+)	NCBI		Celera
Cytogenetic Map	5	p13.2	NCBI
HuRef	5	37,331,535 - 37,705,309 (+)	NCBI		HuRef
CHM1_1	5	37,382,190 - 37,754,780 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	37,629,123 - 38,002,608 (+)	NCBI		T2T-CHM13v2.0

Wdr70
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	7,902,536 - 8,138,787 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	7,902,536 - 8,128,693 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	7,873,055 - 8,099,209 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	7,873,055 - 8,099,209 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	7,823,055 - 8,049,209 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	7,820,270 - 8,046,424 (-)	NCBI		MGSCv36	mm8
Celera	15	7,718,257 - 7,943,539 (-)	NCBI		Celera
Cytogenetic Map	15	A1	NCBI
cM Map	15	3.82	NCBI

Wdr70
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	58,678,651 - 58,918,523 (-)	NCBI		GRCr8
mRatBN7.2	2	56,951,345 - 57,191,244 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	56,951,355 - 57,191,187 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	64,039,336 - 64,279,470 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	62,127,427 - 62,367,319 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	57,128,603 - 57,368,499 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	56,944,462 - 57,196,522 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	56,944,460 - 57,196,568 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	76,953,959 - 77,203,824 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	57,458,217 - 57,701,271 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	57,386,452 - 57,629,504 (-)	NCBI
Celera	2	52,566,824 - 52,805,876 (-)	NCBI		Celera
Cytogenetic Map	2	q16	NCBI

Wdr70
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955426	22,062,323 - 22,344,625 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955426	22,062,872 - 22,344,596 (+)	NCBI	ChiLan1.0	ChiLan1.0

WDR70
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	72,590,641 - 72,956,370 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	70,744,274 - 71,110,013 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	72,626,858 - 72,992,878 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	77,660,323 - 77,931,873 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

WDR70
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	71,028,962 - 71,330,775 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	71,028,965 - 71,330,685 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	70,660,673 - 70,940,473 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	71,545,391 - 71,839,898 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	71,545,391 - 71,849,133 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	71,292,526 - 71,587,677 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	71,405,884 - 71,707,447 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	71,944,544 - 72,240,587 (-)	NCBI		UU_Cfam_GSD_1.0

WDR70
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	22,599,936 - 22,895,796 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	22,599,904 - 22,891,927 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	23,751,897 - 24,025,688 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WDR70
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	36,252,131 - 36,609,430 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	36,252,133 - 36,610,279 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	26,601,433 - 26,963,335 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wdr70
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	17,327,803 - 17,676,616 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624759	17,328,224 - 17,675,920 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005325626	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040273680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000005041 ⟹ ENSSTOP00000004522

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936518	4,343,962 - 4,623,015 (-)	Ensembl

RefSeq Acc Id:

XM_005325626 ⟹ XP_005325683

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	226,748,686 - 227,027,873 (+)	NCBI
SpeTri2.0	NW_004936518	4,343,919 - 4,623,136 (-)	NCBI

Sequence:

show sequence

CTTCCCCGCCCTCCCGCTAGGGCGGCGCTGTTCGGGAAGCCTCCTTGCCTTTGCGGAAGGCGCC
GCTCTTGGCGTTGCGGCATCGCTGACACTCGGAGGCGAGACTTCCTCCGCGGTTGCAGGCTGAG
TGCGGCACCGGTGTGGGCTGCAGCTGCAGGACGTTTCTCTGTGCGGCTTGCCATGGAGCGCTCG
GGGCCCAGCGAAGTGACAGGCTCAGACGCGTCGGGACCCGACCCAGAGCTGGCAGTTACCATGG
GCTTCACGGGGTTCGGAAAAAAAGCTCGCACATTTGACTTGGAAGCTATGTTTGAGCAAACTCG
AAGAACAGCTGTGGAAAGAAGTCGGAAGACACTGGAAGCAAGAGAAAAAGAAGAAGAAATGAAC
AGAGAGAAAGAATTAAGAAGACAAAGTGAAGATATTGAACCCACACCATCAGGCTCAAATATGG
CCAGAGATTGCTCAAAATCATTATCCAGGGATACCAGTAGCAGTGAAAGTGAAGACACTTCTGA
TTCTTCTTCTGATGAGTTAATTGGTCCTCCTTTACCTCCTAAAATGGTAGGAGAACCAGTTAAT
CTTATGGAGGAAGATATCCTTGGGCCTTTACCCCCACCGCTTTATGAAGAAGGAGAAGATGATG
ATGATGACGAAGGAGAAGATGAAGGAGAAGAGGAAAATCCTGTCCAAAAGATTCCTGACTCACA
TGAGATAACACTGAAGCATGGCACTAAAACAGTTTCTGCTTTGGGTCTGGATCCCTCAGGTGCC
CGTTTGGTGACTGGAGGATATGACTACGATGTTAAATTTTGGGACTTTGCTGGAATGGATGCTT
CTTTTAAGGCATTTCGATCCCTTCAGCCCTGTGAATGTCATCAGATCAAGTCATTACAGTACAG
TAACACAGGAGACATGATTCTTGTTGTATCTGGAAGCTCACAGGCCAAGGTGATTGATAGAGAT
GGTTTTGAAGTAATGGAATGTATAAAGGGAGACCAGTATATTGTGGACATGGCCAACACAAAGG
GTCACACAGCAATGCTTCATACTGGCTCATGGCATCCCAAAATAAAGGGAGAATTTATGACTTG
CTCAAATGATGCGACTGTCAGGATATGGGAAGTTGAGAATCCAAGGAAGCAAAAAAGTGTGTTT
AAACCACGGACAATGCAGGGTAAAAAAGTTATTCCTACTACGTGCACATATAGTAGAGATGGAA
ACCTCATAGCAGCTGCCTGCCAGAATGGAAGCATACAGATCTGGGATCGCAATTTAACTGTTCA
TCCTAAATTCCACTATAAACAGGCTCATGACCCAGGCACAGACACTTCTTGTGTGGCTTTTTCC
TATGATGGTAATGTCCTTGCTTCTCGTGGAGGTGATGATACATTAAAATTATGGGATGTCCGAC
AATTTAATAAGCCACTTTTTTCAGCCTTGGGTCTTCCCACCATGTTCCCAATGACTGACTGCTG
TTTTAGTCCAGATGATAAACTCATAGTCACCGGTACCTCTGTTCAAAGGGGATGTGGCAGTGGC
AAACTCGTTTTCTTTGAGCGCAGGACTTTCCAAAGAGTGTATGAAATAGACATCACTGATGCGA
GTGTTGTGCGCTGTCTGTGGCATCCAAAGTTGAACCAGATCATGGTTGGAACTGGAAATGGATT
GGCAAAGGTCTATTATGATCCCAATAAGAGTCAGAGGGGAGCAAAATTATGTGTGGTTAAAACT
CAGCGGAAGGCGAAACAAGCTGAGACTCTAACCCAGGACTACATCATCACTCCTCATGCCTTGC
CTATGTTCCGTGAGCCCCGCCAACGGAGTACCAGGAAACAGCTGGAGAAGGACAGACTGGACCC
CCTAAAGTCACACAAACCTGAACCTCCTGTAGCAGGCCCAGGTCGTGGTGGCCGAGTTGGAACC
CATGGAGGTACTCTTTCTTCCTACATCGTGAAGAACATTGCTCTGGACAAGACTGATGACAGTA
ATCCCAGGGAAGCCATTTTGCGTCATGCCAAAGCAGCAGAAGACAACCCATATTGGGTTTCTCC
AGCTTATTCCAAGACTCAGCCCAAAACTATGTTTGCCCAAGTTGAATCTGATGATGAGGAAGCA
AAGAATGAACCAGAATGGAAAAAACGTAAAATTTGAAGAATTTTGTTTGAGAACCGTTTGCATG
AGAGGAAGGGATGTGGAACAGTGTTTTGATTTCTTTAATGCTTATGAAATAAAAAATGCATTTT
TATGAACAGATTTTGTCCTTTCCATCATTGAGTCATCCAAAAGATTGAT

hide sequence

RefSeq Acc Id:

XM_040273680 ⟹ XP_040129614

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	226,748,679 - 226,754,079 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005325683	(Get FASTA)	NCBI Sequence Viewer
	XP_040129614	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004522.2
GenBank Protein	KAG3266825	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005325683 ⟸ XM_005325626
- Peptide Label:	isoform X1
- UniProtKB:	I3M5C7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MERSGPSEVTGSDASGPDPELAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKE EEMNREKELRRQSEDIEPTPSGSNMARDCSKSLSRDTSSSESEDTSDSSSDELIGPPLPPKMVG EPVNLMEEDILGPLPPPLYEEGEDDDDDEGEDEGEEENPVQKIPDSHEITLKHGTKTVSALGLD PSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKV IDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRIWEVENPRKQ KSVFKPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDPGTDTSC VAFSYDGNVLASRGGDDTLKLWDVRQFNKPLFSALGLPTMFPMTDCCFSPDDKLIVTGTSVQRG CGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLC VVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGG RVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDNPYWVSPAYSKTQPKTMFAQVESD DEEAKNEPEWKKRKI hide sequence

RefSeq Acc Id:	XP_040129614 ⟸ XM_040273680
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSSTOP00000004522 ⟸ ENSSTOT00000005041

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000005031	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000005041.3	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Wdr70	ENTREZGENE
PANTHER	GASTRULATION DEFECTIVE PROTEIN 1-RELATED	UniProtKB/TrEMBL
	WD REPEAT-CONTAINING PROTEIN 70	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	I3M5C7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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