Ddr2 (discoidin domain receptor tyrosine kinase 2) - Rat Genome Database

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Gene: Ddr2 (discoidin domain receptor tyrosine kinase 2) Ictidomys tridecemlineatus
Analyze
Symbol: Ddr2
Name: discoidin domain receptor tyrosine kinase 2
RGD ID: 12459684
Description: ENCODES a protein that exhibits collagen binding (ortholog); INVOLVED IN cell surface receptor protein tyrosine kinase signaling pathway (ortholog); cellular response to angiotensin (ortholog); cellular response to hypoxia (ortholog); ASSOCIATED WITH adenosquamous gallbladder carcinoma (ortholog); alcoholic liver cirrhosis (ortholog); autoimmune interstitial lung, joint, and kidney disease (ortholog); FOUND IN apical plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: discoidin domain receptor tyrosine kinase 2, transcript variant X1; discoidin domain receptor tyrosine kinase 2, transcript variant X2; discoidin domain receptor tyrosine kinase 2, transcript variant X3; discoidin domain receptor tyrosine kinase 2, transcript variant X4; discoidin domain-containing receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050588,484,022 - 8,632,611 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936831865,965 - 946,139 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936831799,948 - 946,139 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biomineral tissue development  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA,ISO)
cellular response to angiotensin  (ISO)
cellular response to hypoxia  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chondrocyte proliferation  (IEA)
collagen fibril organization  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
endochondral bone growth  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of hydrogen peroxide-mediated programmed cell death  (ISO)
negative regulation of kinase activity  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cellular process  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of extracellular matrix disassembly  (IEA)
positive regulation of fibroblast migration  (IEA)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of hepatic stellate cell activation  (ISO)
positive regulation of hepatic stellate cell proliferation  (ISO)
positive regulation of neuron projection development  (IEA)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of wound healing  (ISO)
regulation of bone mineralization  (IEA)
regulation of tissue remodeling  (IEA)
response to muscle stretch  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ddr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050588,484,022 - 8,632,611 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936831865,965 - 946,139 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936831799,948 - 946,139 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,630,863 - 162,787,405 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,631,373 - 162,787,405 (+)EnsemblGRCh38hg38GRCh38
GRCh371162,600,653 - 162,757,195 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,868,852 - 161,016,879 (+)NCBINCBI36Build 36hg18NCBI36
Build 341159,333,917 - 159,481,869NCBI
Celera1135,705,279 - 135,854,329 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1133,847,299 - 133,995,362 (+)NCBIHuRef
CHM1_11164,024,739 - 164,172,823 (+)NCBICHM1_1
T2T-CHM13v2.01161,974,884 - 162,131,644 (+)NCBIT2T-CHM13v2.0
Ddr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,799,874 - 169,938,525 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,799,876 - 169,938,331 (-)EnsemblGRCm39 Ensembl
GRCm381169,972,307 - 170,110,836 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,972,307 - 170,110,762 (-)EnsemblGRCm38mm10GRCm38
MGSCv371171,902,438 - 172,019,075 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361171,814,321 - 171,947,234 (-)NCBIMGSCv36mm8
Celera1172,414,199 - 172,531,584 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map176.84NCBI
Ddr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81384,726,412 - 84,851,032 (-)NCBIGRCr8
mRatBN7.21382,193,623 - 82,318,229 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1382,195,463 - 82,317,363 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1384,825,759 - 84,870,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01386,118,972 - 86,164,115 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,350,999 - 83,395,987 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01388,311,639 - 88,436,561 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1388,317,145 - 88,436,789 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01392,937,900 - 93,062,655 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41385,801,449 - 85,846,636 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11385,816,366 - 85,822,349 (-)NCBI
Celera1381,860,445 - 81,905,616 (-)NCBICelera
Cytogenetic Map13q24NCBI
Ddr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546213,584,724 - 13,642,968 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546213,578,638 - 13,644,834 (-)NCBIChiLan1.0ChiLan1.0
DDR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2186,997,783 - 87,151,567 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1186,666,323 - 86,818,185 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01138,048,730 - 138,200,426 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11141,845,361 - 141,997,082 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1141,932,158 - 141,990,766 (+)Ensemblpanpan1.1panPan2
DDR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13820,002,984 - 20,152,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3820,008,057 - 20,152,275 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3820,058,141 - 20,208,046 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03820,086,562 - 20,234,983 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3820,088,843 - 20,234,493 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13820,061,517 - 20,211,219 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03820,413,313 - 20,562,417 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03820,704,566 - 20,854,433 (-)NCBIUU_Cfam_GSD_1.0
DDR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl487,756,168 - 87,911,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1487,749,738 - 87,911,818 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2495,474,605 - 95,564,964 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DDR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1201,298,636 - 1,451,872 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl201,299,574 - 1,359,674 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038314,909 - 469,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248261,173,621 - 1,249,692 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248261,225,217 - 1,255,889 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000011613   ⟹   ENSSTOP00000010422
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936831865,965 - 946,139 (+)Ensembl
RefSeq Acc Id: XM_005340954   ⟹   XP_005341011
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244050588,484,022 - 8,627,166 (+)NCBI
SpeTri2.0NW_004936831799,948 - 946,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013365516   ⟹   XP_013220970
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244050588,485,071 - 8,627,166 (+)NCBI
SpeTri2.0NW_004936831801,006 - 946,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040287323   ⟹   XP_040143257
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244050588,485,072 - 8,632,611 (+)NCBI
RefSeq Acc Id: XM_040287324   ⟹   XP_040143258
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244050588,484,757 - 8,627,166 (+)NCBI
RefSeq Acc Id: XM_040287325   ⟹   XP_040143259
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244050588,485,071 - 8,627,166 (+)NCBI
RefSeq Acc Id: XM_040287326   ⟹   XP_040143260
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244050588,485,071 - 8,627,166 (+)NCBI
RefSeq Acc Id: XM_040287327   ⟹   XP_040143261
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244050588,484,657 - 8,627,166 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005341011   ⟸   XM_005340954
- Peptide Label: isoform X4
- UniProtKB: I3MHN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013220970   ⟸   XM_013365516
- Peptide Label: isoform X4
- UniProtKB: I3MHN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040143261   ⟸   XM_040287327
- Peptide Label: isoform X4
- UniProtKB: I3MHN7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040143258   ⟸   XM_040287324
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040143260   ⟸   XM_040287326
- Peptide Label: isoform X4
- UniProtKB: I3MHN7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040143259   ⟸   XM_040287325
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040143257   ⟸   XM_040287323
- Peptide Label: isoform X1
RefSeq Acc Id: ENSSTOP00000010422   ⟸   ENSSTOT00000011613
Protein Domains
F5/8 type C   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000011612 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000011613.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.1190 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro DDR1-2_DS-like UniProtKB/TrEMBL
  FA58C UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/TrEMBL
NCBI Gene Ddr2 ENTREZGENE
PANTHER PTHR24416:SF295 UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam DDR1-2_DS-like UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FA58C_1 UniProtKB/TrEMBL
  FA58C_2 UniProtKB/TrEMBL
  FA58C_3 UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/TrEMBL
SMART FA58C UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt I3MHN7 ENTREZGENE, UniProtKB/TrEMBL