Calm2 (calmodulin 2) - Rat Genome Database

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Gene: Calm2 (calmodulin 2) Ictidomys tridecemlineatus
Analyze
Symbol: Calm2
Name: calmodulin 2
RGD ID: 12458536
Description: ENCODES a protein that exhibits adenylate cyclase binding (ortholog); calcium ion binding (ortholog); nitric-oxide synthase binding (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); autophagosome membrane docking (ortholog); calcium-mediated signaling (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH cannabis abuse (ortholog); Cocaine-Related Disorders (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); DAPK1-calmodulin complex (ortholog); growth cone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: calmodulin; calmodulin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,779,344 - 33,795,171 (+)NCBI
SpeTri2.0NW_0049365085,207,909 - 5,223,780 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
autophagosome membrane docking  (ISO)
calcium-mediated signaling  (ISO)
detection of calcium ion  (IEA)
establishment of protein localization to membrane  (ISO)
establishment of protein localization to mitochondrial membrane  (ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO)
negative regulation of calcium ion export across plasma membrane  (IEA)
negative regulation of calcium ion transmembrane transporter activity  (IEA)
negative regulation of high voltage-gated calcium channel activity  (IEA)
negative regulation of ryanodine-sensitive calcium-release channel activity  (IEA)
organelle localization by membrane tethering  (ISO)
positive regulation of apoptotic process  (IEA)
positive regulation of autophagic cell death  (IEA)
positive regulation of cyclic-nucleotide phosphodiesterase activity  (IEA)
positive regulation of DNA binding  (IEA)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphoprotein phosphatase activity  (IEA)
positive regulation of protein dephosphorylation  (IEA)
positive regulation of ryanodine-sensitive calcium-release channel activity  (IEA)
potassium ion transmembrane transport  (IEA)
protein autophosphorylation  (IEA)
regulation of calcium-mediated signaling  (IEA,ISO)
regulation of cardiac muscle cell action potential  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of cyclase activity  (IEA)
regulation of cytokinesis  (IEA)
regulation of heart rate  (IEA)
regulation of high voltage-gated calcium channel activity  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IEA)
regulation of response to tumor cell  (IEA)
regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (IEA)
response to corticosterone  (ISO)
substantia nigra development  (ISO)

References

Genomics

Comparative Map Data
Calm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,779,344 - 33,795,171 (+)NCBI
SpeTri2.0NW_0049365085,207,909 - 5,223,780 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl247,160,084 - 47,176,921 (-)EnsemblGRCh38hg38GRCh38
GRCh38247,160,082 - 47,176,936 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37247,387,221 - 47,404,075 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,240,809 - 47,257,154 (-)NCBINCBI36hg18NCBI36
Build 34247,298,955 - 47,315,301NCBI
Celera247,226,054 - 47,242,551 (-)NCBI
Cytogenetic Map2p21NCBI
HuRef247,124,359 - 47,140,853 (-)NCBIHuRef
CHM1_1247,317,465 - 47,333,922 (-)NCBICHM1_1
Calm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,740,829 - 87,754,363 (-)NCBIGRCm39mm39
GRCm39 Ensembl1787,740,840 - 87,754,363 (-)Ensembl
GRCm381787,433,401 - 87,446,935 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12100,199,435 - 100,209,814 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,433,412 - 87,446,935 (-)EnsemblGRCm38mm10GRCm38
MGSCv371787,832,741 - 87,846,275 (-)NCBIGRCm37mm9NCBIm37
MGSCv361787,341,743 - 87,355,168 (-)NCBImm8
Celera1791,831,455 - 91,844,939 (-)NCBICelera
Cytogenetic Map17E4NCBI
Calm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.267,091,624 - 7,104,284 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl67,091,567 - 7,104,287 (+)Ensembl
Rnor_6.0611,067,675 - 11,080,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1565,506,874 - 65,507,968 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0621,052,945 - 21,068,133 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4664,161,641 - 64,162,751 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11564,177,420 - 64,178,531 (-)NCBI
Celera66,842,934 - 6,855,590 (+)NCBICelera
Cytogenetic Map6q12NCBI
Calm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544113,973,147 - 13,988,665 (-)NCBIChiLan1.0ChiLan1.0
CALM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A48,204,518 - 48,220,697 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A48,204,518 - 48,220,697 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A47,274,722 - 47,290,861 (-)NCBIMhudiblu_PPA_v0panPan3
CALM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,299,698 - 49,314,533 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,299,897 - 49,314,457 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1049,152,937 - 49,167,816 (-)NCBI
ROS_Cfam_1.01050,169,941 - 50,184,842 (-)NCBI
ROS_Cfam_1.0 Ensembl1050,169,946 - 50,184,929 (-)Ensembl
UMICH_Zoey_3.11049,877,637 - 49,892,535 (-)NCBI
UNSW_CanFamBas_1.01050,167,136 - 50,182,012 (-)NCBI
UU_Cfam_GSD_1.01050,351,274 - 50,366,152 (-)NCBI
CALM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,372,045 - 93,438,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1393,371,765 - 93,386,378 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2399,567,552 - 99,582,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CALM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,027,884 - 60,042,041 (+)NCBIChlSab1.1chlSab2
ChlSab1.11460,027,884 - 60,042,041 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl639,957,320 - 39,966,581 (+)EnsemblChlSab1.1chlSab2
ChlSab1.1 Ensembl2468,133,428 - 68,145,180 (+)EnsemblChlSab1.1chlSab2
ChlSab1.1 Ensembl1460,027,801 - 60,044,951 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604551,803,526 - 51,818,114 (-)NCBIVero_WHO_p1.0
Calm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473828,525,290 - 28,541,562 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005324489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010001352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005324489   ⟹   XP_005324546
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629233,779,344 - 33,795,171 (+)NCBI
SpeTri2.0NW_0049365085,207,909 - 5,223,780 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005324546 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3267354 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005324546   ⟸   XM_005324489
- UniProtKB: I3NFJ8 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000014352 UniProtKB/TrEMBL
  ENSSTOG00000021814 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000023145 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000027029 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000019512 UniProtKB/TrEMBL
  ENSSTOT00000040953 UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
NCBI Gene Calm2 ENTREZGENE
Pfam EF-hand_7 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt I3NFJ8 ENTREZGENE, UniProtKB/TrEMBL