Edem3 (ER degradation enhancing alpha-mannosidase like protein 3) - Rat Genome Database

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Gene: Edem3 (ER degradation enhancing alpha-mannosidase like protein 3) Ictidomys tridecemlineatus
Analyze
Symbol: Edem3
Name: ER degradation enhancing alpha-mannosidase like protein 3
RGD ID: 12454186
Description: ENCODES a protein that exhibits calcium ion binding (inferred); hydrolase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); INVOLVED IN glycoprotein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Congenital Disorder of Glycosylation Type IIv (ortholog); Dwarfism (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN endoplasmic reticulum lumen (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ER degradation enhancing alpha-mannosidase like protein 3, transcript variant X1; ER degradation enhancing alpha-mannosidase like protein 3, transcript variant X2; ER degradation enhancing alpha-mannosidase like protein 3, transcript variant X3; ER degradation enhancing alpha-mannosidase like protein 3, transcript variant X4; ER degradation enhancing alpha-mannosidase like protein 3, transcript variant X5; ER degradation enhancing alpha-mannosidase like protein 3, transcript variant X6; ER degradation enhancing alpha-mannosidase like protein 3, transcript variant X7; ER degradation enhancing alpha-mannosidase like protein 3, transcript variant X8; ER degradation-enhancing alpha-mannosidase-like protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934487,506,255 - 87,578,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364815,352,956 - 5,424,944 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364815,352,964 - 5,424,944 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Edem3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934487,506,255 - 87,578,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364815,352,956 - 5,424,944 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364815,352,964 - 5,424,944 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDEM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381184,690,237 - 184,754,858 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1184,690,237 - 184,754,907 (-)EnsemblGRCh38hg38GRCh38
GRCh371184,659,371 - 184,723,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361182,926,260 - 182,990,327 (-)NCBINCBI36Build 36hg18NCBI36
Build 341181,391,294 - 181,455,361NCBI
Celera1157,770,616 - 157,835,009 (-)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1155,895,030 - 155,959,449 (-)NCBIHuRef
CHM1_11186,082,157 - 186,146,571 (-)NCBICHM1_1
T2T-CHM13v2.01184,053,426 - 184,118,046 (-)NCBIT2T-CHM13v2.0
Edem3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,631,099 - 151,698,079 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,631,122 - 151,697,802 (+)EnsemblGRCm39 Ensembl
GRCm381151,755,344 - 151,822,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1151,755,371 - 151,822,051 (+)EnsemblGRCm38mm10GRCm38
MGSCv371153,602,504 - 153,669,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,517,592 - 153,584,546 (+)NCBIMGSCv36mm8
Celera1154,180,540 - 154,247,550 (+)NCBICelera
Cytogenetic Map1G2NCBI
cM Map164.34NCBI
Edem3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81366,403,022 - 66,470,496 (+)NCBIGRCr8
mRatBN7.21363,858,282 - 63,920,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1363,858,716 - 63,920,523 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1366,467,638 - 66,526,178 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01367,745,616 - 67,804,712 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01365,002,139 - 65,060,678 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01369,135,095 - 69,197,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1369,135,128 - 69,199,511 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01374,109,574 - 74,172,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41366,653,931 - 66,712,432 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1363,782,992 - 63,841,218 (+)NCBICelera
Cytogenetic Map13q21NCBI
Edem3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540623,329,400 - 23,401,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540623,329,400 - 23,401,282 (-)NCBIChiLan1.0ChiLan1.0
EDEM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2164,956,321 - 65,029,915 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,642,899 - 64,713,341 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01160,217,526 - 160,281,785 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,372,977 - 164,436,977 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,372,977 - 164,436,977 (-)Ensemblpanpan1.1panPan2
EDEM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1717,918,902 - 17,991,270 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl717,922,334 - 17,991,596 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha717,504,061 - 17,576,419 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0717,655,246 - 17,725,323 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl717,654,411 - 17,725,335 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1717,561,130 - 17,633,489 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0717,669,748 - 17,742,056 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0717,802,533 - 17,872,533 (-)NCBIUU_Cfam_GSD_1.0
EDEM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9125,908,864 - 125,983,029 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19125,908,861 - 125,983,073 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29138,358,619 - 138,428,940 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDEM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12544,619,717 - 44,688,794 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2544,619,861 - 44,685,227 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605545,831,717 - 45,900,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Edem3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248148,838,997 - 8,922,936 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248148,839,016 - 8,924,161 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000012855   ⟹   ENSSTOP00000011520
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364815,352,956 - 5,424,930 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000037578   ⟹   ENSSTOP00000027472
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364815,352,956 - 5,424,944 (+)Ensembl
RefSeq Acc Id: XM_005319695   ⟹   XP_005319752
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934487,506,255 - 87,578,201 (+)NCBI
SpeTri2.0NW_0049364815,352,964 - 5,424,944 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021722557   ⟹   XP_021578232
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934487,506,282 - 87,578,201 (+)NCBI
SpeTri2.0NW_0049364815,352,973 - 5,424,925 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021722558   ⟹   XP_021578233
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934487,506,255 - 87,578,201 (+)NCBI
SpeTri2.0NW_0049364815,352,964 - 5,424,944 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021722560   ⟹   XP_021578235
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934487,506,282 - 87,578,201 (+)NCBI
SpeTri2.0NW_0049364815,352,974 - 5,424,925 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021722562   ⟹   XP_021578237
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934487,506,282 - 87,578,201 (+)NCBI
SpeTri2.0NW_0049364815,352,974 - 5,424,925 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040276763   ⟹   XP_040132697
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934487,506,282 - 87,578,201 (+)NCBI
RefSeq Acc Id: XM_040276764   ⟹   XP_040132698
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934487,506,282 - 87,578,201 (+)NCBI
RefSeq Acc Id: XM_040276765   ⟹   XP_040132699
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934487,506,282 - 87,578,201 (+)NCBI
RefSeq Acc Id: XM_040276766   ⟹   XP_040132700
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934487,506,282 - 87,578,201 (+)NCBI
RefSeq Acc Id: XM_040276767   ⟹   XP_040132701
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934487,524,451 - 87,578,201 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005319752   ⟸   XM_005319695
- Peptide Label: isoform X5
- UniProtKB: A0A287D1S4 (UniProtKB/TrEMBL),   I3MJX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021578233   ⟸   XM_021722558
- Peptide Label: isoform X2
- UniProtKB: I3MJX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021578232   ⟸   XM_021722557
- Peptide Label: isoform X1
- UniProtKB: I3MJX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021578235   ⟸   XM_021722560
- Peptide Label: isoform X3
- UniProtKB: I3MJX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021578237   ⟸   XM_021722562
- Peptide Label: isoform X4
- UniProtKB: I3MJX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040132697   ⟸   XM_040276763
- Peptide Label: isoform X6
- UniProtKB: I3MJX4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040132700   ⟸   XM_040276766
- Peptide Label: isoform X9
- UniProtKB: I3MJX4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040132698   ⟸   XM_040276764
- Peptide Label: isoform X7
- UniProtKB: I3MJX4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040132699   ⟸   XM_040276765
- Peptide Label: isoform X8
- UniProtKB: I3MJX4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040132701   ⟸   XM_040276767
- Peptide Label: isoform X10
- UniProtKB: I3MJX4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000011520   ⟸   ENSSTOT00000012855
RefSeq Acc Id: ENSSTOP00000027472   ⟸   ENSSTOT00000037578
Protein Domains
PA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012848 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012855.3 UniProtKB/TrEMBL
  ENSSTOT00000037578.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
  3.50.30.30 UniProtKB/TrEMBL
InterPro 6hp_glycosidase-like_sf UniProtKB/TrEMBL
  EDEM1/2/3 UniProtKB/TrEMBL
  EDEM3_PA UniProtKB/TrEMBL
  Glyco_hydro_47 UniProtKB/TrEMBL
  PA_dom_sf UniProtKB/TrEMBL
  PA_domain UniProtKB/TrEMBL
  Seven-hairpin_glycosidases UniProtKB/TrEMBL
NCBI Gene Edem3 ENTREZGENE
PANTHER ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3 UniProtKB/TrEMBL
  PTHR45679 UniProtKB/TrEMBL
Pfam Glyco_hydro_47 UniProtKB/TrEMBL
  PF02225 UniProtKB/TrEMBL
PRINTS GLYHDRLASE47 UniProtKB/TrEMBL
Superfamily-SCOP PA domain UniProtKB/TrEMBL
  SSF48225 UniProtKB/TrEMBL
UniProt A0A287D1S4 ENTREZGENE, UniProtKB/TrEMBL
  I3MJX4 ENTREZGENE, UniProtKB/TrEMBL