Acot4 (acyl-CoA thioesterase 4) - Rat Genome Database

Name: Acot4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Acot4 (acyl-CoA thioesterase 4) Ictidomys tridecemlineatus

Analyze

Symbol:

Acot4

Name:

acyl-CoA thioesterase 4

RGD ID:

12453223

Description:

ENCODES a protein that exhibits fatty acyl-CoA hydrolase activity (inferred); succinyl-CoA hydrolase activity (inferred); thiolester hydrolase activity (inferred); INVOLVED IN butyrate metabolic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); FOUND IN peroxisome (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

acyl-coenzyme A thioesterase 4; peroxisomal succinyl-coenzyme A thioesterase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	29,152,711 - 29,157,109 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	2,912,016 - 2,914,995 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936488	2,912,016 - 2,914,995 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acyl-CoA metabolic process (IEA)

butyrate metabolic process (ISO)

dicarboxylic acid catabolic process (IEA)

dicarboxylic acid metabolic process (IEA)

fatty acid metabolic process (IEA)

long-chain fatty acid metabolic process (IEA)

saturated monocarboxylic acid metabolic process (IEA)

short-chain fatty acid metabolic process (IEA)

succinyl-CoA metabolic process (IEA)

unsaturated monocarboxylic acid metabolic process (IEA)

very long-chain fatty acid metabolic process (IEA)

Cellular Component

peroxisome (IEA)

Molecular Function

fatty acyl-CoA hydrolase activity (IEA)

succinyl-CoA hydrolase activity (IEA)

thiolester hydrolase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Acot4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	29,152,711 - 29,157,109 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	2,912,016 - 2,914,995 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936488	2,912,016 - 2,914,995 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACOT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	73,591,873 - 73,595,766 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	73,591,873 - 73,595,766 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	74,058,577 - 74,062,470 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	73,128,163 - 73,132,223 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	14	54,094,503 - 54,098,556 (+)	NCBI		Celera
Cytogenetic Map	14	q24.3	NCBI
HuRef	14	54,226,329 - 54,230,382 (+)	NCBI		HuRef
CHM1_1	14	73,998,002 - 74,002,055 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	67,799,383 - 67,803,276 (+)	NCBI		T2T-CHM13v2.0

Acot4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	84,084,028 - 84,091,497 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	84,085,153 - 84,095,375 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	84,037,254 - 84,044,723 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	84,038,379 - 84,048,601 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	85,379,329 - 85,385,673 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	84,928,127 - 84,934,471 (+)	NCBI		MGSCv36	mm8
Celera	12	85,484,852 - 85,491,186 (+)	NCBI		Celera
Cytogenetic Map	12	D1	NCBI
cM Map	12	39.01	NCBI

Acot4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	109,399,032 - 109,405,138 (+)	NCBI		GRCr8
mRatBN7.2	6	103,668,699 - 103,674,037 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	103,668,753 - 103,673,917 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	103,830,503 - 103,835,783 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	104,129,719 - 104,134,999 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	103,499,170 - 103,504,450 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	107,517,668 - 107,522,952 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	107,517,668 - 107,522,952 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	118,021,264 - 118,026,536 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	108,075,508 - 108,080,792 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	101,498,707 - 101,503,970 (+)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

ACOT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	74,680,646 - 74,687,296 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	73,895,275 - 73,907,168 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	54,150,843 - 54,155,119 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	73,008,597 - 73,012,673 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	73,008,909 - 73,012,561 (+)	Ensembl	panpan1.1		panPan2

ACOT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	46,889,326 - 46,894,379 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	46,852,880 - 46,911,640 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	46,573,784 - 46,580,670 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	47,118,497 - 47,125,383 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	8	46,786,164 - 46,791,040 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	46,804,351 - 46,811,227 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	47,194,704 - 47,201,587 (+)	NCBI		UU_Cfam_GSD_1.0

LOC100158115
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	96,868,157 - 96,949,358 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	96,941,065 - 96,945,834 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	102,787,631 - 102,791,737 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACOT4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	50,806,736 - 50,811,294 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	50,807,212 - 50,811,181 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	38,972,271 - 38,996,921 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005321208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000003330 ⟹ ENSSTOP00000002979

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936488	2,912,016 - 2,914,995 (+)	Ensembl

RefSeq Acc Id:

XM_005321208 ⟹ XP_005321265

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	29,152,711 - 29,157,109 (-)	NCBI
SpeTri2.0	NW_004936488	2,912,016 - 2,914,995 (+)	NCBI

Sequence:

show sequence

TCCAGCATGGCAGCGACGCTGATCCTGGAGCCCGCCAGCCACTGCTGCTGGGACCAGCCGGTAC
ACATCACCGTGCGTGGCCTGGCCCCCAAGCAGAGGGTCACGCTGCGCGCTTCCCTGCGCGACGA
GAAGGGCGCGCTCTTCCGCGCCCACGCGCGCTACCTCGCGGACGCAGGGGGCGAGCTGGACCTG
GAGCGCGCGCCCGCGCTGGGCGGCAGCTTCGCGGGCCTGGAGCCCATGGGGCTGATCTGGGCCA
TGGAGCCTGATAAGCCGTTTTGGCGCATGGTGAAGCGGGACGTGCAGACGCCCTTCGTGGTGGA
GCTGGAGGTGCTGGACGGCCACGAGCCTGACGCTGGGCGGCTGCTGGCCCGGGCGCTGCACGAG
CGCCACTTCCTGCCGCCCGGGGTCCAGCGGGTGCCGGTGCGGGAGGGCAGGGTGCGGGCCACGC
TCTTCCTGCCGCCAGGACCTGGACTCTTCCCCGGGGTCATTGATATCTACGGAGTTGGAGGAGG
CCTGTTGGAATATCGGGCCAGCCTTCTGGCTGGCCATGGCTTTGCCACATTGGCTGTAGCTTTT
TATAACTTTGATGATCTCCCCAAGGATTTCAGCAACATACACCTGGACTACTTTGAAGAAGTTG
TGTGCTACATGCTTCAACACCCCCAGGTAAAGGGCCCAGGTGTTGGGCTTCTGGGCATTTCTCT
AGGAGCTGACATTTGTCTCTCAATGGCCTCATTCTTGAAGAATATCTCAGCCACTGTATCCATC
AATGGATCTGGGAGCAGCGGAAACTCAACTATACACTACAAGCAGATTAGCATCCCACCACTGG
GCATTGACCTGAATCGAATCAAGGTTACTTTCTCAGGCATTCTGGACATTGTGGATATTCGGAA
TGATATTGTGGAGAAGTTTGAGAACCCCAGTATGATTCCAATAGAGAAGGCACAAGGGCCCATC
CTCTTCATTGCTGGTCAGGATGACCATAACTGGAGGAGTGACTTAAATGTGCAAATAGTCTCTG
AAAGACTACAGGCCCATGGAAAGGAAAAACCCAGGATCATCCTTTATCCTGGGACTGGGCACTA
CATTGAGCCTCCTTACTTCTCCATGTGCCCAGCTTCTGTGCACAAAATGTTCAACAAAGTTGTG
ATCTGGGGTGGGGAGCTCAGGGCTCATTCTAAGGCCCAGGTGGATGCCTGGAAGCAAATTCTGT
CCTTCTTCTCCCAACACCTTGGAGGCACCCACAAGGTGTCCCCCAAGTTGTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005321265	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000002979.2
GenBank Protein	KAG3260729	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005321265 ⟸ XM_005321208

- UniProtKB:

I3M233 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAATLILEPASHCCWDQPVHITVRGLAPKQRVTLRASLRDEKGALFRAHARYLADAGGELDLER
APALGGSFAGLEPMGLIWAMEPDKPFWRMVKRDVQTPFVVELEVLDGHEPDAGRLLARALHERH
FLPPGVQRVPVREGRVRATLFLPPGPGLFPGVIDIYGVGGGLLEYRASLLAGHGFATLAVAFYN
FDDLPKDFSNIHLDYFEEVVCYMLQHPQVKGPGVGLLGISLGADICLSMASFLKNISATVSING
SGSSGNSTIHYKQISIPPLGIDLNRIKVTFSGILDIVDIRNDIVEKFENPSMIPIEKAQGPILF
IAGQDDHNWRSDLNVQIVSERLQAHGKEKPRIILYPGTGHYIEPPYFSMCPASVHKMFNKVVIW
GGELRAHSKAQVDAWKQILSFFSQHLGGTHKVSPKL

hide sequence

RefSeq Acc Id:

ENSSTOP00000002979 ⟸ ENSSTOT00000003330

Protein Domains

Acyl-CoA thioester hydrolase/bile acid-CoA amino BAAT/Acyl-CoA thioester hydrolase C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000003338	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000003330.3	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.2240	UniProtKB/TrEMBL
	3.40.50.1820	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	Acyl-CoA_thioEstase_long-chain	UniProtKB/TrEMBL
	BAAT_C	UniProtKB/TrEMBL
	Thio_Ohase/aa_AcTrfase	UniProtKB/TrEMBL
	Thio_Ohase/BAAT_N	UniProtKB/TrEMBL
NCBI Gene	Acot4	ENTREZGENE
PANTHER	ACYL-COENZYME A THIOESTERASE-RELATED	UniProtKB/TrEMBL
	PEROXISOMAL SUCCINYL-COENZYME A THIOESTERASE	UniProtKB/TrEMBL
Pfam	BAAT_C	UniProtKB/TrEMBL
	Bile_Hydr_Trans	UniProtKB/TrEMBL
PIRSF	Acyl-CoA_hydro	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	I3M233	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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